{"content"=>"Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABA) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity.", "sub"=>{"content"=>"A"}} (original) (raw)

Synthesis and Pharmacological Evaluation of Novel GABAASubtype Receptor Ligands with Potential Anxiolytic-like and Anti-hyperalgesic Effect

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Bioorganic & Medicinal Chemistry Letters, 2009

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{"__content__"=>"Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.", "sub"=>{"__content__"=>"A"}}

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Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents

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Bioorganic & Medicinal Chemistry Letters, 2008

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Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators

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ChemInform Abstract: Synthesis and Pharmacological Evaluation of Pyrazoline Derivatives as New Antiinflammatory and Analgesic Agents

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Tricyclic pyridones as functionally selective human GABAAα2/3 receptor-ion channel ligands

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In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor 5 Subtype-Selective Inverse Agonist

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New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor

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Bioorganic & Medicinal Chemistry, 2011

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Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: A new class of GABAA brain receptor ligands

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The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at α1 Subunit-Containing GABAA Receptors

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3-Alkyl- and 3-amido-isothiazoloquinolin-4-ones as ligands for the benzodiazepine site of GABAA receptors

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The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at 1 Subunit-Containing GABAA Receptors

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Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site

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Bioorganic & Medicinal Chemistry Letters, 2005

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Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA α5 inverse agonists with potential for the treatment of cognitive dysfunction

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Bioorganic & Medicinal Chemistry Letters, 2009

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Design, Synthesis, and Characterization of New 1,3,5-Trisubstituted-2-pyrazolines Derivative for Analgesic Potential

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An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site

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Proceedings of the National Academy of Sciences of the United States of America, 1985

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