Development of liposomes for improved topical treatment of methicillin-resistant Staphyloccocus aureus (MRSA) infections (original) (raw)

2017

Abstract

The objective of this study was development and in vitro evaluation of liposomes for the topical treatment of chronic skin infections. Various types of liposomes differing in lipid composition and surface properties were prepared and examined for physical characteristics, in vitro drug release and antimicrobial activity. Soy phosphatidylcholine (SPC) liposomes and dipalmitoylphosphatidylcholine (DPPC)/dioctadecyldimethylammonium bromide (DODAB) liposomes encapsulating azithromycin were prepared by conventional film hydration method, followed by extrusion (SPC liposomes) or probe sonication (DPPC/DODAB liposomes). Anionic SPC liposomes were additionally coated with 0.3% (w/v) low Mw chitosan. Mean diameters, polydispersity index and zeta potentials of different phospholipid vesicles were determined by photon correlation spectroscopy. In vitro release studies were performed by Franz diffusion-cell method at 32 C using buffer pH 7.5 as receptor medium [1]. Antimicrobial activity of de...

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