Study of histopathological patterns of salivary gland lesion (original) (raw)
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HISTOPATHOLOGICAL SPECTRUM OF SALIVARY GLAND TUMOURS: A HOSPITAL BASED STUDY
Background: Salivary gland tumors are common neoplasms of head and neck region. These tumors are complex andsome of them exhibit great deal of morphologic overlap .The majority of these neoplasms are benign. These tumours can occur in both major and minor salivary glands. 80% of major salivary gland tumoursoccur in the parotid glands, while most minor salivary tumours are located in the palate. As a general rule in clinical practice, the smaller the salivary gland is, the more likely the tumouris malignant. Objective: This study was carried out to study the histopathological spectrum of salivary gland tumors and to know their pattern of distribution. Material and Methods:-This is a two year retrospective study which was conducted in the Post graduate department of pathology Government Medical College Srinagar from January 2015 to December 2016 . Post surgical specimens were studied in detail to know the histological patterns. In each patient, age, sex, site and histopathological diagnosis was seen from record section of the department. The histological diagnosis of each individual tumor was based on the 2005 WHO classification of salivary gland tumors. Results:- During two year ( from January 2015 to December 2016), 100 cases of salivary gland tumors were diagnosed with peak incidence in third to fourth decade (48%).Among these, 63(63%) cases were benign and 31(31%) cases were malignant. The commonest site was parotid gland (68%) followed by submandibular glands(19%) and minor salivary gland tumors were 13%. Among benign tumours of salivary glands pleomorphic adenoma (42%) was most common followed by Warthintumour (12%),basal cell adenoma (7%) andMyoepithelioma (2%) and among malignant tumours,Mucoepidermoid carcinoma (46%) was most common followed by Adenoid cystic carcinoma (32.5%), Carcinoma ex pleomorphic adenoma (10.8%), Acinic cell carcinoma and Polymorphous low grade adenocarcinoma each comprising of (5.4%). Conclusion: Histopathological study of salivary gland lesions is the most important method in establishing the final diagnosis and accordingly guides in the specific management.
Clinicopathological Analysis of Salivary Gland Tumours: An Observational Study
2019
Background: Salivary gland tumour is a comparatively sporadic and morphologically varied collection of pathologic entities. Hence; we histopathologically analyzed the salivary gland tumour in the present study.Materials & methods: The present analysis included histopathologic assessment of salivary gland neoplasms. All the biopsies received in the department were recorded. H and E stained slides were made and were assessed by experienced and certified oral pathologists. Histopathologic diagnosis were recorded in Microsoft excel sheet and were analyzed by SPSS software. Results: Biopsies of a total of 70 salivary gland neoplasms were studies in the present study. Among these, 40 were benign while the remaining 30 were malignant in nature. Total frequency of occurrence of Pleomorphic adenoma, Basal cell adenoma and Warthin’s tumour was 25.6%, 10% and 14.2% respectively. Frequency of occurrence of Adenoid cystic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma, polymorphous low...
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: Salivary gland tumours constitute 3-4% of all head and neck cancers (mostly benign). These tumours are epithelial (95%) or mesenchymal in origin. Pleomorphic adenoma is the most common benign salivary gland tumour and mucoepidermoid carcinoma (45%) is the most common malignant salivary gland tumour followed by adenoid cystic carcinoma (30%). The parotid, submandibular and the minor salivary glands of palate are commonly involved and the sublingual gland is rarely affected.Methods: Hospital based cross sectional study was done in a tertiary care centre during a period of 1 year, which included 21 patients (10 men and 11 women). Patients were analysed according to age, gender, food habits, histopathological type and site of the tumour and treatment strategy.Results: All the cases were from upper Assam province sharing a particular demographic pattern between 19-65 years. Peak incidence in males was fourth decade and females was third decade. Male female ratio was 0.9:1. Ou...
Salivary gland tumors: a 15-year experience of a universıty hospital in Turkey
Northern Clinics of Istanbul
T he salivary glands consist of three major glands as parotid, submandibular and sublingual glands and hundreds of minor glands, which are diffusely located in the beginning part of the respiratory system. Tumors of the salivary glands are rarely encountered. However, they appear with different histopathological characters. Different biological behaviors can be observed even in neoplasms defined by the same name. In the latest classification made by the World Health Organization (WHO) in 2017, salivary gland tumors were classified into more than 30 benign and malignant histologic subtypes [1]. This wide histopathological spectrum and significant differences in prognosis between them distinguish salivary gland tumors from other organ neoplasms. Salivary gland tumors account for approximately 3-4% of all head and neck tumors [2]. Their inci-ABSTRACT OBJECTIVE: To determine the demographic characteristics of benign and malignant salivary gland tumors in our department in the last 15 years. METHODS: In this study, the files of the patients who underwent salivary gland surgery between 2004 and 2019 in our department were analyzed retrospectively. A total of 366 patients whose diagnoses of salivary gland tumor histopathologically confirmed were included in this study. The demographic data of the patients and tumor localizations were recorded, and their relationships with histopathological results were examined. RESULTS: Of the 366 tumors, 292 (80%) of them was originated from the parotid gland, 52 (14%) from the submandibular gland, and 22 (6%) from the minor salivary gland. The male: female ratio was found as 1.2:1, and the mean age of the patients was 50.37 years. A total of 259 (70.8%) tumors were benign, and 107 (29.2%) were malignant. The most frequent benign tumor was pleomorphic adenoma, with 121 cases (46.7%). While pleomorphic adenomas constituted the majority of the benign tumors of the submandibular gland and minor salivary glands, Warthin tumor was detected more than pleomorphic adenoma in the parotid gland. The most common malignant tumor was mucoepidermoid carcinoma, with 26 cases (24.3%). CONCLUSION: The distribution of the salivary gland tumors detected in our department was found to be substantially similar to other worldwide series. Unlike the literature, we concluded that salivary gland tumors were seen slightly more in males, minor salivary gland tumors were relatively rare and Warthin tumors were more frequently detected in our region.
Histopathological Spectrum of Salivary Gland Lesions
2009
Background: Salivary gland tumors are rare neoplasms that generate interest due to their histopathological diversity. Several studies have reported a significant difference in the global distribution of salivary gland tumors, but no formal study has been carried out in this part of the globe. Aim: To study the histopathological spectrum of salivary gland lesions and to know the pattern of distribution in Tripura, a state in North Eastern India. Materials and Methods: This is a 7 years (2010-2016) retrospective study of all salivary gland tumor specimens received at our referral teaching hospital in Tripura, India. All the slides were reviewed by the authors. Clinical details were obtained from the archives. Data thus collected were analyzed. Results: A total of 46 cases were studied during the study period. Of them 37 cases were benign and 9 cases were malignant. Age ranged from 12 years to 88 years with an overall female preponderance. Parotid (78.26%) was the commonest gland involved. Both benign (29 out of 36 cases) and malignant tumors (7 out of 9 cases) were more common in parotid. Pleomorphic adenoma was the commonest benign tumor (25 cases) and adenoid cystic carcinoma was the commonest malignancy (4 cases). Conclusion: The principal site of salivary gland tumors was the parotid gland and pleomorphic adenoma outnumbered all the other tumors. Adenoid cystic carcinoma was the most common malignant tumor.
Tropical Journal of Pathology and Microbiology, 2018
Background: Salivary gland tumors (SGTs) are rare neoplasm of head and neck region. The salivary gland tumours vary widely in histopathological appearance. Also, epidemiological data of these tumors in various parts of the world are different. And so the study of SGTs for their biology and clinical characteristics can be helpful for a better understanding. Objectives: The objective of this study was to study types and new entities, common site of distribution and histomorphological spectrum of salivary gland tumors (SGTs). Materials and Methods: It was a retrospective followed by prospective study. Pertinent clinical history like age, duration of the lesion, site of the lesion, significant family and personal history, history of associated diseases was recorded. Specimens consisted of incisional biopsies were examined microscopically by the expert pathologist. Details of specimens noted in Performa include dimensions, appearance of external and cut surface and presence of lymph nodes, their size and number. Observations: Total 70 cases of SGTs could be included in the study. Among them 56 (80%) were benign and 14 (20%) were malignant. Parotid is commonest salivary gland involved with 75.71% of all tumors, followed by submandibular with 21.42% and minor salivary glands with 1(1.4%) of salivary gland tumors. among benign tumors Pleomorphic adenoma is most common with 70% of all benign SGTs followed by Warthin tumors (7%). Among malignant tumors commonest is Mucoepidermoid carcinoma with 14.28% of all SGTs. Female preponderance was clearly found in malignan at SGTs. Conclusion: Parotid is most common site for the SGT. And pleomorphic adenoma and the Warthin tumors are the common benign tumors involve parotid gland the most. Among malignant tumors mucoepidermoid carcinoma are the commonest with female preponderance. While other carcinoma like adenoid cystic carcinoma and SCC are also common.
Morphological pattern of salivary gland tumours
JPMA. The Journal of the Pakistan Medical Association, 2001
To delineate the spectrum of salivary gland tumors in our setup. The Aga Khan University Medical Centre, Karachi. Tumors were analysed considering histological type, age and sex of the patients and anatomic location. The diagnosis of individual tumours was based on the 1991 World Health Organisation Classification. During the span of eight years (1991-1998), 379 cases of salivary gland tumours were diagnosed. Of these, 205 (65.7%) were male and 174 (34.3%) were female. The median age at the time of diagnosis was 35 years. The median age for patients with malignant lesions (44 years) was 12 years older than those with benign tumours (34 years). Overall, malignant tumours were seen more frequently in males, however benign tumours were distributed equally between the two sexes. The most common site was parotid gland (82.85%). Only five cases of minor salivary gland tumours were seen. The most frequently diagnosed benign salivary gland neoplasm was pleomorphic adenoma (84.5%), followed ...
Incidence & Pattern of Salivary Gland Tumors -A Clinicopathological Study
IOSR Journals , 2019
Background: The salivary glands are one of the few tissues in the body that are subjected to diverse and heterogeneous range of tumors and tumor like conditions. The relative infrequency of these tumors makes their diagnosis and management quite complicated. Fine needle aspiration cytology (FNAC) is a useful diagnostic procedure which has a recognized role in the evaluation of salivary gland lesions. A pre-operative diagnosis about nature of lesion, whether benign or malignant, will help in making decision about proper management of patient. Objective: Aim of this study was to know the incidence of various salivary gland tumors in our region using fine needle aspiration cytology and taking histopathology as the gold standard. Method: It was prospective observational study conducted in department of oral ans maxillofacial surgery in our institute. Total 80 cases were studied with particular reference to age, sex, site, cytologic details & histological types as per WHO classification. FNAC & histopathological examination was done in all cases from the department of Pathology Govt. Medical College Srinagar. Diagnostic accuracy of FNAC was evaluated by comparing cytological & histopathological diagnoses. Results: Maximum number of patients was in age range of 41-50 years & male to female ratio was 2:3. Most common benign & malignant tumors were pleomorphic adenoma (69.89% cases) & mucoepidermoid carcinoma (8.60% cases) respectively. On cytology, 73 cases while on histopathology 76 cases were diagnosed as neoplastic. Conclusion: parotid gland was the most commonly affected site followed by submandibular gland and minor salivary glands. FNAC in salivary gland masses is fairly reliable for correct preoperative diagnosis.
Retrospective study of 124 cases of salivary gland tumors and literature review
Journal of Clinical and Experimental Dentistry
Background: Salivary gland tumors are a rare and morphologically diverse group of lesions and their frequency is still unknown in several parts of the world. The knowledge of its population characteristics contributes to a better understanding of its etiopathogenesis. Objectives: This study investigated the frequency of salivary gland tumors in a region of southern Brazil and compared these data in a literature review. Material and Methods: A retrospective study was conducted of salivary gland tumors diagnosed at two pathology centers from 1995 to 2016. Patient age and gender, tumor site and frequency, histopathological diagnosis, and symptomatology were evaluated. Chi-squared tests were used to assess the associations between variables. To compare our data, we also conducted a literature review of publications in the PubMed and LILACS databases of retrospective studies of salivary gland tumors. Results: A total of 124 salivary gland tumor cases was identified, 81 (65.3%) of which were classified as benign and 43 (34.6%) as malignant. Most tumors occurred in the parotid gland (57.2%). Pleomorphic adenoma was the most common tumor (59.6%), followed by adenocarcinoma not otherwise specified (8.8%). The tumors occurred more often in women (54.8%) than in men (45.2%). Malignant tumors were associated with pain in 31.4% of cases (p <0.05). The literature review included 35 articles from different countries. Women were most affected, with a mean age of 41.7 years. The most common benign tumor was pleomorphic adenoma (48.2%) and the most common malignant tumor was mucoepidermoid carcinoma (8.7%). Conclusions: The results of the present study showed that salivary gland tumors are rare. The parotid gland is the most common location and pleomorphic adenoma are the most frequent lesions. The malignant tumors presented as several histological types and the incidence was variable globally.
Histopathological Study of Salivary Gland Lesions
International Journal of Scientific Research, 2014
Introduction: There is a wide spectrum of salivary gland lesions with morphologically and clinically diversity which is a difficult task for histopathological interpretation. There are three major salivary glands-parotid, submandibular, and sublingual as well as minor salivary glands distributed throughout the mucosa of the oral cavity. Neoplastic and non-neoplastic disease may develop within any of these. Aims: (1) To study the histopathological features of salivary gland lesions, (2) To study the prevalence of salivary gland lesions in tertiary care hospital, (3) To evaluate the incidence, age at the occurrence, and sex ratio among the patients with salivary gland lesions, (4) To compare the result of our study with other studies. Material and Method: Retrospective study was done from January 2016 to June 2018. The study was done on 55 specimens from patients with salivary gland lesions which are referred to the Department of Pathology from Department of ENT and Surgery, P.D.U. Medical college, Rajkot. Salivary gland specimens were immediately fixed in 10% formalin and processed by paraffin embedding. Sections were stained by hematoxylin and eosin stain. Finally, microscopic examination was done to diagnose Result: In present study, out of 55 cases, 05 cases (9.1%) were inflammatory, 41 cases (74.5%) were benign and 09 cases (16.4%) were malignant. Most common benign tumor of salivary gland was pleomorphic adenoma followed by Warthin's tumor. Most common malignant tumor of salivary gland was mucoepidermoid carcinoma. Conclusion: Histopathological study of salivary gland lesions is the most important method in establishing the final diagnosis and subtyping. Salivary gland tumors are relatively less common and they exhibit a wide variety of microscopic appearances even within one particular lesions.