The growing role of two-dimensional LC in the biopharmaceutical industry (original) (raw)

This article discusses the increasing significance of two-dimensional liquid chromatography (2D-LC) technology in the biopharmaceutical sector, particularly in conjunction with mass spectrometry (MS). It highlights recent advancements in 2D-LC instrumentation and methods, emphasizing their enhanced resolving power and applicability in analyzing complex biopharmaceutical mixtures, such as monoclonal antibodies. The paper focuses on the integration of different chromatographic modes within 2D-LC to provide more comprehensive analytical capabilities, thus supporting the growing demands of biopharmaceutical analysis.