Lipid Hydroperoxide Levels, Oxidative Status and Glucose Absorption in Rodents Following BDE-85 Exposure (original) (raw)

2012, Journal of the Pennsylvania Academy of Science

The Polybrominated Diphenyl Ethers (PBDEs) are a class of synthetic flame retardant compounds which are available in three commercial forms, penta BDEs, octa BDEs, and deca BDEs. Because of their extensive commercial use they have become widespread environmental contaminants. BDE-85 is a congener of the penta variety; to the best of the authors' knowledge there are no studies reported on the toxicity potential of this compound. This study reports the effects of BDE-85 on the oxidative stress and glucose absorption in rodents. Oxidative stress was measured using oxidative stress markers, lipid hydroperoxides in conjunction with activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase in mice kidney and intestine tissues after exposure to 0.25 mg/kg body weight of BDE-85 via intraperitoneal route for four days. Mice tissues showed significant alterations (p<0.05) in the oxidative stress markers. L...

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact