Poly(methylmetacrylate) (PMMA) core-shell nanospheres act as efficient pharmacophores for the antiproliferative [PtCl3(NH3)]- complex by forming ionic couples (original) (raw)

Inorganica Chimica Acta, 2009

Michele Laus

Raffaella Ravizza

Abstract

Polymer-based, covalently linked drug-delivery systems have been shown to improve the therapeutic index of effective but toxic anticancer agents, such as cisplatin, by exploiting the peculiar features of tumour blood and lymphatic circulation. In the present study, positively charged poly( ...

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