Wilms' tumor: a 10 year retrospective study (original) (raw)
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Journal of Clinical Pathology, 2010
In the International Society of Paediatric Oncology renal tumour trials, preoperative chemotherapy has been successfully applied with resulting reduction of tumour rupture and increased favourable stage distribution of nephroblastoma. Postoperative treatment includes chemotherapy and sometimes radiotherapy in a riskadapted approach based on histological sub-classification and stage of the tumour. However, preoperative chemotherapy alters the tumour's histological features and distribution of subtypes, and makes staging more difficult. The paper highlights the most common practical diagnostic difficulties that a pathologist is faced with in dealing with pretreated nephroblastomas. It emphasises the importance of a systematic, step-by-step analysis based on adequately sampled material, in order to accurately sub-classify a nephroblastoma as a low, intermediate or high risk tumour and assign its genuine stage. Finally, it outlines the standard operating procedure for submission of renal tumours for rapid central pathology review which allows the treating oncologists to apply the optimal treatment protocol.
2010
In the International Society of Paediatric Oncology renal tumour trials, preoperative chemotherapy has been successfully applied with resulting reduction of tumour rupture and increased favourable stage distribution of nephroblastoma. Postoperative treatment includes chemotherapy and sometimes radiotherapy in a riskadapted approach based on histological sub-classification and stage of the tumour. However, preoperative chemotherapy alters the tumour's histological features and distribution of subtypes, and makes staging more difficult. The paper highlights the most common practical diagnostic difficulties that a pathologist is faced with in dealing with pretreated nephroblastomas. It emphasises the importance of a systematic, step-by-step analysis based on adequately sampled material, in order to accurately sub-classify a nephroblastoma as a low, intermediate or high risk tumour and assign its genuine stage. Finally, it outlines the standard operating procedure for submission of renal tumours for rapid central pathology review which allows the treating oncologists to apply the optimal treatment protocol.
Long-term Outcome in Children with Wilms’ Tumor; Experience of a Single Center for Two Decades
2021
Background: Wilms’ tumor (nephroblastoma) is the major renal cancer in children. Objectives: The aim of this study was to assess the individuality of Wilms’ tumor and the consequences of management attained in our referral subspecialty center. Methods: In this study, we composed the data of children with Wilms’ tumor in 2 decades; 55 cases between 1992 and 2002 and 49 patients between 2006 and 2016 were diagnosed with Wilms’ tumor. Demographic characters, a form of presentation, tumor stage, related underlying disease, histopathology consequences, type of management, and the survival rates were assessed. Results: In the first decade, 24 patients were females and 31 were males (M/F = 1.2); in the other groups, 30 were females and 19 were males (M/F = 0.61). The mean age was 45.2 months at the time of diagnosis for the first group and the mean age was 36 months for the other group. In the first decade, the surgical stage after the operation was as follows: stage I (32.7%), stage II (1...
Wilms Tumor and Its Management in a Surgical Aspect
Wilms Tumor, 2016
Nephroblastoma [Wilms tumor (WT)] is a rare, but the most common, primary renal tumor in children. WT is usually diagnosed between the ages of 1 and 5, with the most common diagnosis at the age of 3. While imaging (ultrasound, computed tomography, and magnetic resonance) can accurately predict up to 95% of WTs, they cannot predict the histologic subtypes and require tissue examination. Surgery is one of the cornerstones of WT treatment. Other aspects of management include chemotherapy and radiation therapy. The Societe Internationale D'oncologie Pediatrique (SIOP) advocates primary chemotherapy in patients less than 6 months of age, whereas the Erginel 44 Children's Oncology Group (COG) recommends primary surgery in all cases except those considered not resectable by the surgeon. In this chapter, the surgical therapy of WT is reviewed.
A Retrospective Study of Wilms Tumour in Our Institute
Introduction: Wilms tumor (WT) accounting for 6-7% of all childhood cancers is the most common renal tumour in childhood. We conducted this study to review the outcome of multimodality treatment of Wilms' tumor at our institute. Material and Methods: The clinicopathological profile of 8 cases of Wilms' tumor between 2011-2015 were studied with NWTS (National Wilms' Tumor Study Group) protocol. Data was retrospectively analyzed to determine the outcome of treatment which consisted of unilateral Radical Nephrectomy followed by radiotherapy and chemotherapy based on histopathological staging of the tumor. Results: Eight patients were diagnosed and confirmed histopathologically as Wilms' tumor between june 2011 through june 2015 and outcomes correlated with age, laterality of tumour, sex, stage at presentation and histology. Favourable histology including focal anaplasia was found in 62.5% while unfavourable histology was elicited in 37.5% of the cases. On follow up, six out of eight patients are doing well while one had pulmonary metastasis and one expired. Conclusion: We successfully managed cases of wilms tumour with comparable results of other studies.
Wilms Tumor (Nephroblastoma), Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
Journal of the National Comprehensive Cancer Network
The NCCN Guidelines for Wilms Tumor focus on the screening, diagnosis, staging, treatment, and management of Wilms tumor (WT, also known as nephroblastoma). WT is the most common primary renal tumor in children. Five-year survival is more than 90% for children with all stages of favorable histology WT who receive appropriate treatment. All patients with WT should be managed by a multidisciplinary team with experience in managing renal tumors; consulting a pediatric oncologist is strongly encouraged. Treatment of WT includes surgery, neoadjuvant or adjuvant chemotherapy, and radiation therapy (RT) if needed. Careful use of available therapies is necessary to maximize cure and minimize long-term toxicities. This article discusses the NCCN Guidelines recommendations for favorable histology WT.
A rare case of a Wilms tumor: case report
2018
The nephroblastoma or Wilms tumor (WT) is the most common renal tumor in childhood, representing approximately 6-7% of all pediatric cancers, with a yearly incidence of 10 cases in one million children less than 15 years old, and continues to arouse interest by remarkable actual therapeutic successes, consecutive to the multidisciplinary approach. Its maximum incidence is around the age of 3-3.5 years old, having an equal frequency in males and females. We present the case of a child, aged three years and five months, who was diagnosed with WT (nephroblastoma) with triphasic pattern, stage II tumor, and admitted to the Department of Oncopediatry for chemotherapeutic treatment and clinico-biological investigations.
Adult Wilms' Tumour: Case Report and Review of Literature
Journal of Kidney Cancer and VHL, 2016
Wilms' tumour (nephroblastoma) is the most common renal tumour in children. Wilms' tumour in adults is extremely rare and has a poorer prognosis than paediatric Wilms' tumour. It is difficult to differentiate adult Wilms' tumour from renal cell carcinoma based on radiological findings alone. The diagnosis in adults is often serendipitous following nephrectomy for presumed renal cell carcinoma. Because of the paucity of literature, there are no standard protocols for the management of adult Wilms' tumour, and therefore, it is managed as per paediatric Wilms' tumour. Herein, we report the case of adult Wilms' tumour in a 43-year-old man, which was diagnosed unexpectedly following nephrectomy for presumed renal cell carcinoma.
Case Report on Wilm’s Tumor in Children
Journal of Pharmaceutical Research International, 2021
Introduction: Wilms tumor is the most frequent kind of kidney cancer in kids. It is responsible for around 6% of all tumors in children. In children under the age of 15, the incidence is 7.6% cases per million, with 75% of cases occurring before the child reaches the age of five. A variant term for wilms tumor is nephroblastoma. It is most widespread between the ages of three and four, after which it becomes much less frequent. Clinical Findings: Wilms tumor in children produces one or more of the following signs and symptoms: Abdominal pain Increasing abdominal girth Lack of appetite Fever Blood in the urine Nausea or vomiting. Constipation Shortness of breath Diagnostic Evaluation: Increase abdominal girth, pain, fever, vomiting, cried at the time of urination, hematuria, black stool, pallor, hypertension and moderate microcytic anemia (Iron deficiency). Ultrasonography: Splenomegaly Therapeutic Investigation: X- ray of abdomen and chest, IVP, USG, MRI, CT scan, renal function te...
Wilms tumor (nephroblastoma) in the adult patient: clinical and radiologic manifestations
American Journal of Roentgenology, 1989
Wilms tumor (nephroblastoma), a primary renal neoplasm containing primitive bIastema and embryonic glomerulotubular structures, is seen rarely in adults. To identify clinical and radiologic criteria for preoperative diagnosis of adult Wilms tumor, we studied 29 cases reported in the literature from 1975 to 1987 (all patients were 15 years old or older) and four newly diagnosed cases.