The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia–associated NUP214 fusion proteins regulate Notch signaling (original) (raw)

The nuclear pore proteins Nup88 and Nup214 play significant roles in regulating the Notch signaling pathway, which is crucial for developmental processes and cell fate decisions. This study reveals that Nup88/214 negatively regulate Notch signaling by inhibiting the nuclear export of RBP-J in mammalian cells and shows their involvement in Notch signaling regulation in zebrafish. Additionally, the NUP214 fusion proteins associated with T-cell acute lymphatic leukemia may influence tumorigenesis through a Notch-dependent mechanism.