Isolation and Toxicity of Steroidal Alkaloid Glycoside from Fruits of Ranti Hitam (Solanum blumei Nees ex Blume) (original) (raw)

2016, Asian Journal of Chemistry

Ranti hitam (Solanum blumei Nees ex Blume) (Solanaceae) is found in Dairi and Karo, North Sumatera, Indonesia. Traditionally fruits of S. blumei have been used as drugs, such as pain medication, fever, abdominal pain, ear pain and antiinflammatory. To best of our knowledge, the chemical and pharmacological studies on S. blumei reports still limited. Simorangkir et al. [1] have reported that the phytochemical extracts of leaves and fruits of S. blumei conducted in accordance with the method of Harborne [2] show that the ethyl acetate extract of this plant contains alkaloids, steroids and flavonoids while the ethanol extract has many alkaloids, saponins and flavonoids bit, phenols and tannins. The n-hexane extract consists of steroids, triterpenoids and little amount of alkaloids. The highest extraction result is obtained in the extracted ethanol of leave and fruit compared with extracts of n-hexane and ethylacetate. The results of toxicity test by Brine Shrimp Lethality Test method (BSLT) [3] for fruit extracts of S. blumei showed that the ethanol extract of S. blumei fruit had the highest toxicity than ethyl acetate and n-hexane extracts with LC 50 values in a row i.e. 21.10; 321.14 and 573.61 µg/mL [4]. According to Atanu et al. [5], toxicological properties of the Solanum plant are likely caused by alkaloid content contained in Solanum plants. Based on the results of some tests that have been made