Hydrogen sulfide plays a role in the development of hepatopulmonary syndrome (original) (raw)
BACKGROUND & AIM OF THE STUDY: Hepatopulmonary syndrome (HPS) is an important pulmonary complication of cirrhosis and portal hypertension, characterized by intrapulmonary vasodilatation (IPVD) leading to impaired oxygenation. Prevalence of this syndrome varied from 5 to 30% in different studies. Hydrogen sulfide (H2S), which is generated by vascular smooth muscle cells and liver by enzyme cystathione γ-lyase, has vasodilatory effect. Current study aimed at determining the prevalence of clinical and subclinical HPS in cryptogenic cirrhosis and establishing the role of H2S in pathogenesis of HPS. METHODS: During the period of January 2012 to November 2013, consecutive patients with cryptogenic cirrhosis were enrolled after a written informed consent. Diagnosis of cirrhosis was made by history, liver function abnormalities, endoscopy and abdominal ultrasonography. Chest x-ray, arterial blood gas analysis (ABG) and contrast echocardiography (CE) was done in all patients. HPS was diagnos...
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