Influence of the Escherichia coli Nissle 1917 strain on complications of the chronic experimental liver damage (original) (raw)

The aim of the study was evaluate the influence of the probiotic Escherichia coli Nissle 1917 strain (Mutaflor® suspension, Ardeypharm GmbH, Herdecke, Germany) on bacterial translocation in cases of liver damage, damage to the intestinal mucosa, potential portal hypertension associated with possible development of oesophageal varices and on the bacterial population of the intestine during chronic experimental liver damage in the laboratory rat. Rats with liver damage induced by thioacetamide were divided into an experimental and control group. Experimental and control animals were applied Mutaflor and saline, respectively. Samples of blood, liver, lymph nodes and caecum for microbiological examination, of liver, duodenum and oesophagus for histological examination and of spleen for weight evaluation were collected. There were no significant differences between both groups of animals in the qualitative proportion of Staphylococcus spp., Enterococcus spp. and Proteus spp. cultured fro...