ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform (original) (raw)

Tissue-specific alternative splicing influences the generation of diverse protein isoforms. ELAV, a Drosophila neuron-specific RNA-binding protein, plays a crucial role in facilitating the production of a neural isoform of Neuroglian by regulating pre-mRNA splicing. This study demonstrates that ELAV is essential for the expression of the neural-specific isoform in neurons and that its ectopic expression can induce this isoform in non-neuronal cells, revealing its role in neuron-specific gene regulation.