Dynamic chromosomal rearrangements in Hodgkin's lymphoma are due to ongoing three-dimensional nuclear remodeling and breakage-bridge-fusion cycles (original) (raw)

Dynamic chromosomal rearrangements in Hodgkin's lymphoma were investigated, focusing on the mechanisms behind these alterations. The study reveals that ongoing three-dimensional nuclear remodeling and breakage-bridge-fusion cycles play a critical role in shaping these rearrangements. Through a combination of advanced karyotyping and imaging techniques, the authors illustrate the complexities of chromosome behavior in different cellular contexts, providing insights into the molecular underpinnings that may contribute to the pathology of Hodgkin's lymphoma.