Fluoride and endosulfan together potentiate cytogenetic effects in Swiss albino mice bone marrow cells (original) (raw)

In this study, the cytotoxic potential of fluoride and endosulfan in combination was investigated in Swiss albino mice bone marrow cells using the chromosomal aberration (CA) and micronucleus (MN) test systems. Fluoride (25.1 mg kg−1 body weight [bw] in water) and endosulfan (1.8 mg kg−1 bw by oral intubation) were administered orally alone and in combination (fluoride 25.1 mg kg−1 bw + endosulfan 1.8 mg kg−1 bw) to male Swiss albino mice daily for 30 days. A significant ( p < 0.01) increase in micronuclei (MNs) induction and decreased ratio ( p < 0.01) of polychromatic to normonochromatic erythrocytes (indicators of cytotoxicity) were observed compared with saline controls when animals were given the combination of fluoride and endosulfan. A significant ( p < 0.01) increase in MNs induction and no change in the polychromatic erythrocytes to erythrocyte ratio were also observed when endosulfan was given alone. CAs such as gaps, breaks, fragments, rings, exchanges, and polyp...