Human and mouse ALS tissue sections immunolabeled for FUS, SFPQ, ChAT and counterstained with DAPI (original) (raw)

2020

Abstract

Multichannel microscopy data from histopathological sections of 1/ Tissue sections from spinal cord of SOD1- and VCP-mutant ALS mouse models together with control immunolabeled for FUS, SFPQ, ChAT and counterstained with DAPI. 2/ Tissue sections from spinal cord of Healthy and sporadic ALS donors immunolabeled for FUS or SFPQ, ChAT and counterstained with DAPI. 3/ Scripts to preprocess these images. These two series of multichannel fluorescent microscopy data have been used in several manuscripts including: <strong>Luisier R, Tyzack GE, Hall CE, Mitchell JS, Devine H, Taha DM, et al. Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS. Nat Commun 2018; 9: 2010.</strong> <strong>Tyzack GE, Luisier R, Taha DM, Neeves J, Modic M, Mitchell JS, et al. Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis. Brain 2019; 142: 2572–80.</strong>

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