A quantitative understanding of lac repressor’s binding specificity and flexibility (original) (raw)
High-Resolution Specificity from DNA Sequencing Highlights Alternative Modes of Lac Repressor Binding
Gary Stormo
Genetics, 2014
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Altered Specificity in DNA Binding by the lac Repressor: A Mutant lac Headpiece that Mimics the gal Repressor
Roberto Salinas
ChemBioChem, 2005
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AlloRep: a repository of sequence, structural and mutagenesis data for the LacI/GalR transcription regulators
Daniel Parente
Journal of molecular biology, 2015
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Subdividing Repressor Function: DNA Binding Affinity, Selectivity, and Allostery Can Be Altered by Amino Acid Substitution of Nonconserved Residues in a LacI/GalR Homologue †
Hongli Zhan
Biochemistry, 2008
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Exploring the sequence-function relationship in transcriptional regulation by the lac O1 operator
Ramesh Jha
FEBS Journal, 2012
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Perturbation from a Distance: Mutations that Alter LacI Function through Long-Range Effects †
Hongli Zhan
Biochemistry, 2003
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Specificity and Affinity of Lac Repressor for the Auxiliary Operators O2 and O3 Are Explained by the Structures of Their Protein–DNA Complexes
Hans Wienk
Journal of Molecular Biology, 2009
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Lac repressor genetic map in real space
Jeffrey Miller
Trends in Biochemical Sciences, 1997
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Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator O1 through alternative conformations of its DNA-binding domain
Roberto Salinas
The EMBO Journal, 2002
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Modified nucleotides reveal the indirect role of the central base pairs in stabilizing the lac repressor-operator complex
Philip A Gottlieb
Nucleic Acids Research, 1995
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Functional consequences of exchanging domains between LacI and PurR are mediated by the intervening linker sequence
Susan Egan
Proteins: Structure, Function, and Bioinformatics, 2007
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Weak operator binding enhances simulated lac repressor-mediated DNA looping
Andrew Colasanti
Biopolymers, 2013
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Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins
Sarah Bondos
Journal of Biological Chemistry, 2015
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Assignment of the 1H-NMR spectrum of a lac repressor headpiece-operator complex in H2O and identification of NOEs. Consequences for protein-DNA interaction
Rolf Boelens
European Journal of Biochemistry, 1990
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LAC REPRESSOR: A genetic and nuclear magnetic resonance study of structure and function
Ponzy Lu
Biophysical Journal, 1980
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Molecular parameters characterizing the interaction of Escherichia coli lac repressor with non-operator DNA and inducer
Peter Von Hipel
Biochemistry, 1977
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Orientation of the Lac repressor DNA binding domain in complex with the left lac operator half site characterized by affinity cleaving
Richard Ebright
Nucleic Acids Research, 1991
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Analysis of in-vivo LacR-mediated gene repression based on the mechanics of DNA looping
Stephen Levene
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Local Gene Regulation Details a Recognition Code within the LacI Transcriptional Factor Family
Francisco Camas
PLOS Computational Biology, 2010
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Repressor--operator interaction in the lac operon. III. Nuclear magnetic resonance observations with altered amino-terminal DNA binding domains
Harry Nick
Journal of Molecular Biology, 1982
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Interconvertible Lac Repressor–DNA Loops Revealed by Single-Molecule Experiments
Martin Guthold
PLoS Biology, 2008
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The lac operator is DNA
W. Gilbert
Proceedings of the National Academy of Sciences, 1967
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Repressor-operator interaction in the lac operon
Harry Nick
Journal of Molecular Biology, 1982
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Lac Repressor: a proton magnetic resonance look at the deoxyribonucleic acid binding fragment
Ponzy Lu
Biochemistry, 1981
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Comparative genomics and evolution of regulons of the LacI-family transcription factors
Aleksandra Rakhmaninova
Frontiers in Microbiology, 2014
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A single mutation in the core domain of the lac repressor reduces leakiness
Sean Devenish, Willem Dijkman
Microbial Cell Factories, 2013
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FRET studies of a landscape of Lac repressor-mediated DNA loops
sachin goyal
Nucleic Acids Research, 2012
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A family of bacterial regulators homologous to Gal and Lac repressors
S. Adhya
Journal of Biological Chemistry, 1992
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Represser-operator interaction in the lac operon
Ponzy Lu
Journal of Molecular Biology, 1982
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Genetic assignment of resonances in the NMR spectrum of a protein: lac repressor
Ponzy Lu
Proceedings of the National Academy of Sciences, 1981
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