Effect of Deep Brain Stimulation Parameters on Speech Intelligibility and Speech Acoustics in Parkinson's Disease (original) (raw)

Abstract

Background: Deep brain stimulation of the sub-thalamic nucleus (DBS-STN) is a common neurological treatment for individuals with Parkinson’s Disease (PD). DBS-STN is hypothesized to increase motor-related cortical activity by disrupting the disease-related inhibition of the cortical-basal ganglia-thalamus motor system. While DBS-STN has positive effects on most major motor symptoms in PD, its effect on speech intelligibility is inconsistent and may produce significant impairments in some individuals (Iulianeli, Adams, & Gow. 2008; Skodda, 2012). These variable effects on speech may be related to fundamental differences in the speech and limb motor systems that are associated with different levels of responsiveness to specific stimulation parameter settings. The present investigation will systematically examine a range of DBS-STN stimulation settings in order to study the relationship between DBS-STN settings and speech intelligibility. Objectives: This study will explore and evaluat...

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