Evaluation of therapeutic potential and anti-hyperchlostrolemic effects of prunes in albino rats: An experimental study (original) (raw)
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2017
Background: Hyperlipidemia and underlying high cholesterol has been reported among the top five leading cause of global mortality. Many drugs and extracts from plant origin and specifically from Indian plants have been reported and used for hyperlipidemia alleviation. Objective: The present study was aimed to evaluate antioxidant and anti-hyperlipidemic activity of hydroalcoholic and aqueous extract of Prunella vulgaris Linn. against high-fat diet induced oxidative stress and hyperlipidemia in Wistar rats. Materials and Methods: Hyperlipidemia and oxidative stress was induced in wistar rats with high-fat diet ad libitum. The hyperlipidemic rats were then treated with gavage feeding with aqueous and hydroalcoholic extract of Prunella vulgaris at different doses (100, 250 and 500 mg/kg b.wt./day). The effect was compared with standard drug Lovastatin (7.2mg/Kg). Results: The high-fat diet showed marked increase in the lipid profile levels in rats as measured by enzyme analytical metho...
Use of prunes as a control of hypertension
Journal of Ayub Medical College, Abbottabad : JAMC, 2010
BACKGROUND Fruits and vegetables are shown to reduce blood pressure. It is not merely the antioxidants contained in fruits and vegetables that have health benefits such as lowered systolic and diastolic blood pressures. This study was undertaken to see the cardiovascular protective effects of prunes. METHODS A placebo controlled clinical trial study was designed to see the effects of Prunus domestica on blood pressure in 259 pre-hypertensive (Systolic BP = 120-139 mmHg, diastolic BP = 80-89 mmHg) volunteers. Treated groups drank prune juice and ate the whole fruit (dried plums) while either 3 (about 11.5 gm) or 6 prunes were soaked overnight in a glass of water whereas control group took only a glass of plain water early in the morning on empty stomach. Blood pressure was recorded fortnightly for 8 weeks, and blood samples were taken at 0 and 8 weeks. RESULTS There was significant reduction of blood pressure by single dose of prunes daily group and the controls (p < 0.05). With t...
Study of Polyphenolic Extracts of Prunus Domestica L. Wall Nuts As Hypolipidemic Agents
The goal of this study is to investigate the effect of polyphenolic in order to extract Prunus domestica red (PDR) and Prunus domestica yellow (PDY) wall nuts on some physiological and biochemical parameters in female rats in vivo and antibacterial activity in vitro. The working of this thesis involves the following terms: Analytical study: the Analytical study demonstrates the presence of polyphenols in PDR and PDY. The UV-Vis Spectra and high performance liquid chromatography of extracted poly-phenolic are proved for presence of (Tannic acid, Gallic acid, Caffeic acid, Vanillic acid, Ferulic acid, amygdalin, Chlorogenic acid). Biochemical parameters: all rats in Bio-chemical parameters are divided into normal control group (A), hyperlipidemia positive control group (B), and the rest of the two groups (C & D) are served as experimental groups. Group(C) of hyperlipidemic experimental rats received the extracted poly-phenolic of PDR at 25 mg/kg of body weight for 30 days on daily basis. While group (D) rats is received the extracted poly-phenolic of PDY at 25 mg/kg of body weight for 30 days on daily basis. Whilst blood samples collects after 30 days. Lipid profile: the positive hyperlipidemic control group s rats showed variable increases in serum triglycerides, LDL, VLDL and total cholesterol levels. Serum HDL levels are decreases in positive hyperlipidemic control groups. PDR and PDY have decreased the levels of these parameters in rats. Consequently the PDR reduces the lipid levels more and in effectively way than PDY do.
Journal of Medicinal Plants Research, 2012
Prunes are dried fruits of several species of Prunus, including that of Prunus domestica Linn (Rosaceae) and are used for the treatment of hypertension in traditional systems of medicine in India and Pakistan. We investigated the blood pressure lowering, angiotensin converting enzyme (ACE) inhibitory and diuretic activities of the aqueous-methanolic crude extract of dried fruits of P. domestica (Pd.Cr.) in rats. Intravenous administration of the Pd Cr decreased mean arterial blood pressure, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the ketamine-diazepam anesthetized normotensive rats dose-dependently, at the dose range of 1 to 30 mg/kg. In vitro, the extract was fond to have serum ACE inhibitory activity, with IC 50 value of 1.102 mg/ml. The extract did not increase urine output in rats. The study concludes that the crude extract of prunes has hypotensive and ACE inhibitory activities, which provides scientific justification for its traditional uses as cardioprotective and antihypertensive remedy.
THE EFFECT OF FEEDING Mucuna pruriens SEED MEAL ON THE SERUM LIPIDS OF ALBINO RATS
The serum lipid levels of rats fed with different percent (10,20 and 50%) raw and cooked Mucuna pruriens seed meal inclusions in the feed were investigated. Powdered raw and cooked Mucuna pruriens seed meal were incorporated into the feed of the test rats while normal feed was given to the negative control rats for 28 days. At the end of the test period, blood samples were collected from each rat for analysis. Parameters analyzed were serum total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C). In the rats fed with cooked M. pruriens seeds meal in the feed, the serum total cholesterol, triglycerides and LDL-C were significantly (p<0.05 – p<0.004) reduced when compared to the negative control rats. Also the serum HDL-C was also significantly (p<0.05) increased in the test rats. In the rats fed with powdered raw M. pruriens seed meal, there was just marginal decrease in serum total cholesterol and triglycerides which was not statistically significant but the serum LDL-C was significantly (p<0.05) reduced. The HDL-C was also marginally increased. In conclusion, the results of this study show that M. pruriens seed meal has a lipid lowering effect on serum lipids which was more pronounced with the cooked seed meal. KEYWORDS: Mucuna pruriens, Total cholesterol, Triglycerides, HDL-C, LDL-C.
This study examined the antihyperlipidaemic effect of Almond seed (Prunus amygdalus) on Alloxan induced diabetic rats. Sixty male albino rats were divided into six groups (A-F) representing the positive and negative controls, and the test groups for four weeks were used. Diabetes were induced in groups C, D, E and F, except for group A and B which served as the positive control and negative control, respectively. Diabetic rats with blood glucose level greater than 11.00mmol/l were included in the study. The test groups were fed with 60g of prepared almond granules while the controls were fed with standard feed for four weeks. Lipid profile tests were performed weekly. The results of the positive and negative control gave significant increase in TC, TG and LDL, but none in HDL. There was significant decrease in the TC, TG, and LDL levels of the test group compared with the control for week1-4 (p<0.05). While there was significant increase in the HDL level of the test group compare...
Prunus divaricata (Alloocheh) is a small tree cultivating in Iran, Middle East and central Asia. Prunus genus has many species with anti-oxidant, anti-hyperlipidemia and anti-hyperglycemia effects. In the present study the anti-diabetic and anti-hyperlipidemic effects of P. divaricata fruits were examined in normal and streptozotocin (STZ)-induced diabetic rats. Both groups, control and reference rats received normal saline and glibenclamide respectively. Test groups were treated with Prunus freeze dried juice (PFDJ, 200, 400, 800 mg/kg) and Prunus freeze dried extract (PFDE, 100, 200, 400 mg/kg) started at the 3 rd day of the experiment and continued for 27 days thereafter. Weight changes of animals were checked periodically. Fasting blood glucose (FBG) level as well as serum triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol were determined. Different treatments had no significant effect on body weight increments of normal rats, while in diabetic rats, PFDJ (800 mg/kg) and PFDE (400 mg/kg) opposed with weight loss. In acute phase of experiment (0-8 h of 3 rd day), none of tested fractions were effective in reducing FBG and serum lipids of normal rats. During the sub-acute phase (13 th and 30 th days) however, the greatest test doses of PFDJ (800 mg/kg) and PFDE (400 mg/kg) induced hypoglycema. In diabetic groups, PFDJ and PFDE, at all test doses, could diminish FBG during sub-acute phase of the experiment. In addition, PFDJ and PFDE at most examined doses could diminish TG significantly and they were also effective on cholesterol derivatives in different magnitude.
The Journal of nutrition, 1994
Previous research indicated that prunes in the diet of men with hypercholesterolemia lowered plasma and LDL cholesterol concentrations. To further study lipid metabolism in response to ingesting prunes, we conducted an animal study to test the hypotheses that fiber extracted from prunes, compared with purified cellulose, lowers plasma and liver cholesterol in rats with diet-induced hyperlipidemia and that the response is dose dependent. Rats were randomly assigned to one of five experimental diet groups. Four of the diets contained cholesterol and cholic acid to induce hyperlipidemia. The fiber source in the hyperlipidemic diets was 6% cellulose, 3% prune fiber, 6% prune fiber or 3% pectin. The fifth group, the nonhyperlipidemic control, was fed a diet containing 6% cellulose without cholesterol or cholic acid. Rats consumed one of the five diets ad libitum for 28 d, then were killed after 16 h without food. Plasma, LDL and liver cholesterol concentrations were higher in the hyperli...
Journal of medicinal plant research
The fat, fiber and carotenoid composition from Caryocar brasiliense pulp points out this exotic fruit as a potential cardio protective food. This study aimed to evaluate the hyoplipidemic effect of pequi pulp in rats. Proximate composition, fatty acid profile and carotenoids of pequi dehydrated pulp were determined. Next, groups of male rats were fed a standard diet (AIN93M), a control diet (CTRL) added 10% lard, P400 or P600 diets, both similar to CTRL, added pequi pulp to provide 400 or 600 mg of pequi oil per day, respectively. At the end, serum cholesterol, high-density lipoproteins (HDL), triglycerides and glucose, liver and fecal lipids analysis were performed. Pequi pulp had 63.61% of lipids, mainly monounsaturated fatty acids, its fiber content were 17.95% and carotenoids 16,11 mg/100 g. Adding fat to the diets did not increase food intake. There were no changes on serum cholesterol and glucose. The higher level of pequi added increased, similarly, HDL and triglycerides in t...