Fridmann-Sirkis Membrane Proteins and Their Involvement in Infectious Diseases Department of Biological Chemistry (original) (raw)

Protein-membrane interactions and proteinprotein recognition within the membrane milieu are of fundamental importance to fully comprehend a wide range of cellular processes in all organisms. About 40% of all genes in the mammalian genome transcribe for membrane proteins. The paucity in 3D structures for most membrane proteins, the high complexity of the forces involved, and the technical difficulties present challenging obstacles to overcome before fully understanding biological events within membranes. Using a multidisciplinary approach, including cell molecular biology (cells and viruses), biophysics and biochemistry, we study the mode of action of membrane proteins, particularly those involved in infectious diseases. The principle underlying our approach is the dissection of the proteins to small fragments, which are studied for their structure, function, their ability to interfere with the function of the parental intact proteins, and network of peptide-peptide recognition withi...

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