The Mitochondrial b-c1 Complex: Polypeptide Composition and Enzymatic Activities (original) (raw)

Organelles in Eukaryotic Cells, 1989

Abstract

The second segment of the respiratory chain of mitochondria (b-c1 complex, complex III or ubiquinol-cytochrome c reductase, E.C. 1.10.2.2) is an oligomeric integral protein of approx. 240 kDa in a monomeric form, which catalyses the transfer of electrons from ubiquinol or synthetic analogs to ferricytochrome c. The flow of reducing equivalents from dehydrogenase or quinols to cytochrome c, along the b-c1 complex, results in the effective translocation of two protons from the matrix space (Negative phase) to the outer space (Positive phase); two additional protons, deriving from the scalar oxidation of a hydrogen donor, are released in the P phase, thus giving an overall H+/2e− stoicheiometry of 4.

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