Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor—5-HT1A/5-HT2A/5-HT7 and D2/D3/D4—agents: The synthesis and pharmacological evaluation (original ) (raw )Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity
Magdalena Jastrzębska-więsek
Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
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Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors
Krzysztof Marciniec
European Journal of Medicinal Chemistry, 2013
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N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists
Ramakrishna Nirogi
Bioorganic & Medicinal Chemistry Letters, 2012
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Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A /5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity
Grażyna Chłoń-Rzepa
Archiv der Pharmazie, 2016
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Derivatives of cis-2-Amino-8-hydroxy-1-methyltetralin: Mixed 5-HT1A-Receptor Agonists and Dopamine D2-Receptor Antagonists
Tommy Lewander
Journal of Medicinal Chemistry, 1995
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Characterization of a novel and potent 5-hydroxytryptamine1A receptor antagonist
Linda Liau
Pharmacology Biochemistry and Behavior, 1991
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6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors
Giancarlo Merlo
Bioorganic & Medicinal Chemistry Letters, 2008
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Towards a New Generation of Potential Antipsychotic Agents Combining D 2 and 5-HT 1A Receptor Activities
Adrian Newman-Tancredi
Journal of Medicinal Chemistry, 2007
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Novel Spirohydantoin Derivative as a Potent Multireceptor-Active Antipsychotic and Antidepressant Agent
Adam Bucki , Anna Wesołowska
Bioorganic & Medicinal Chemistry, 2015
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Novel and Highly Potent 5-HT3 Receptor Agonists Based on a Pyrroloquinoxaline Structure
Maurizio Anzini
Journal of Medicinal Chemistry, 1997
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F 11440, a Potent, Selective, High Efficacy 5-HT 1A Receptor Agonist with Marked Anxiolytic and Antidepressant Potential
Karlsson Ek , M. Kleven
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A 5-HT1A ligand with both antidepressant and anxiolytic properties
jerry M cott
Psychopharmacology bulletin, 1988
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Design, Synthesis, and Pharmacological Evaluation of Piperidin-4-yl amino aryl sulfonamides: Novel, Potent, Selective, Orally Active, and Brain Penetrant 5-HT 6 Receptor Antagonists
parandhama gudla
Journal of Medicinal Chemistry, 2012
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8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors—Part II
Massimo Gianotti
Bioorganic & Medicinal Chemistry Letters, 2009
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5-HT6 Receptor antagonists. I. Screening of the library of various heterocyclic compounds containing an alkylsulfonyl moiety
Ilya Okun
Pharmaceutical Chemistry Journal, 2012
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New 5-HT1A receptor ligands containing a N′-cyanoisonicotinamidine nucleus: Synthesis and in vitro pharmacological evaluation
Beatrice Severino , Paola Massarelli
Bioorganic & Medicinal Chemistry Letters, 2010
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3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity
Steven Bromidge
Bioorganic & Medicinal Chemistry Letters, 2005
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Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity
Aleksandra Klodzinska
Bioorganic & Medicinal Chemistry, 2006
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Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores
Seth Ablordeppey
Bioorganic & Medicinal Chemistry, 2016
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Novel Derivatives of 2-Pyridinemethylamine as Selective, Potent, and Orally Active Agonists at 5-HT 1A Receptors
M. Kleven
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Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: A comparative study of coupling to Gαs
Clotilde Mannoury la Cour
European Journal of Pharmacology, 2008
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Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1H-Pyrrolo[3,2-c]quinolines with Neuroprotective and Procognitive Activity
Martyna Krawczyk
ACS Chemical Neuroscience, 2019
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Medicinal chemistry strategies to 5HT 6 receptor ligands as potential cognitive enhancers and antiobesity agents
Helmut Buschmann
Drug Discovery Today, 2006
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Sulfonamides with the N-alkyl-N′-dialkylguanidine moiety as 5-HT7 receptor ligands
Maciej Pawłowski
Bioorganic & Medicinal Chemistry Letters, 2009
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