Disseminated cutaneous phaeohyphomycosis due to Cladophialophora bantiana (original) (raw)
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Subcutaneous phaeohyphomycosis caused by cladophialophora boppii
Indian Journal of Dermatology, Venereology, and Leprology, 2010
A case of subcutaneous phaeohyphomycosis caused by Cladophialophora sp. is reported. The patient, an immunosuppressed host presented a nodule on the dorsum of the right hand which relapsed four months after excision. Dematiaceous septate hyphal and yeast like elements were seen in mycological and histological examination. The isolated fungus was identified on the basis of micro-macromorphological and physiologic characteristics.
Revista da Sociedade Brasileira de Medicina Tropical, 2019
We report a rare case of subcutaneous phaeohyphomycosis caused by Cladophialophora bantiana in an immunocompetent patient in Amazonas, Brazil. This dematiaceous fungus has been mainly associated with life-threatening infections affecting the central nervous systems of immunosuppressed patients. We present the clinical, laboratory, and therapeutic aspects, and in vitro susceptibility test results for different antifungal drugs. A brief review of the cases reported in the literature over the past 20 years has also been discussed. According to the literature review, the present case is the first report of subcutaneous phaeohyphomycosis due to C. bantiana in an immunocompetent patient in Latin America.
Phaeohyphomycosis caused by Cladophialophora bantiana
Revista Iberoamericana de Micología, 2014
Background: Cladophialophora bantiana is the most frequent cause of central nervous system phaeohyphomycosis. Objective: We report a case of phaeohyphomycosis by C. bantiana in a patient with underlying lung disease on steroid therapy. Methods: An 81-year-old male was admitted in August 2011 with a history of difficulty speaking and deflection of the oral commeasure to the left side with a brain abscess. Brain tissue was cultured on Sabouraud media and sequence analysis of the internal transcribed spacer region of the ribosomal DNA was done for identification purposes. Susceptibility testing to various antifungal agents was performed using the microdilution test. Results: Histopathological examination of the brain tissue ruled out malignancy and the presence of dematiaceous hyphae was observed. Culture showed the presence of a single black fungus, identified as C. bantiana. It was susceptible to all antifungals, except caspofungin. The patient was treated with voriconazole plus liposomal amphotericin B. Cerebral cranial computed tomography [CCT] scans demonstrated persistence of the intraparenchymal abscess collection. Despite surgical and medical treatment with antifungal drugs, the patient died 5 months after the first diagnosis of the cerebral occupying lesion was made. Conclusions: Phaeohyphomycosis is an uncommon infection with severe limitations on the clinical clues that can help in early diagnosis. Fungal species identification is mandatory for epidemiological and therapeutic reasons. The MICs could be useful in selecting the appropriate antifungal agent. Avoiding the unnecessary exposure to soil or other media potentially contaminated with fungal spores should be recommended to any immunosuppressed patient.
Mycoses, 2003
We report the case of a patient suffering from subcutaneous phaeohyphomycosis caused by Cladophialophora bantiana. The face of the upper site was involved with small, stellate, pyogranulomatous foci and low inflammation. The patient was treated by topical and systemic corticosteriod and amphotericin B. After 3 months of treatment, the patient showed good response. Zusammenfassung Es wird eine subkutane Phaeohyphomykose, verursacht durch Cladophialophora bantiana bei einer 45-jährigen Frau vorgestellt, die im Gesicht kleine, sternförmige, eitrig-granulomatöse Herde mit geringer Entzü ndungreaktion aufwies. Sie wurde topisch und systemisch mit Corticoiden und Amphotericin B behandelt mit gutem Erfolg nach drei Monaten.
Current Medical Mycology, 2020
Background and Purpose: Fungal infections of the central nervous system (CNS) are life-threatening conditions that are frequently misdiagnosed with bacterial and viral CNS infections. Cerebral phaeohyphomycosis is a cerebral infection caused by dematiaceous fungi, especially Cladophialophora bantiana. Very few cases of fungal CNS infection have been reported across the world. High clinical suspicion should be cast for the patients with brain abscess that do not respond to conventional antibiotic therapy. Case report: We report a case of a 21-year-old male presenting with headache, seizures and weakness in the limbs. Radiological examination revealed multiple brain abscesses. After surgical excision and laboratory evaluation, it was found to be caused by C. bantiana. The patient’s outcome was good with surgical excision and voriconazole therapy. Conclusion: Brain abscess caused by C. bantiana is on rise, especially in immunocompromised groups. Thus, high clinical suspicion, accurate ...
Cerebral phaeohyphomycosis due to Cladophialophora bantiana
Indian Journal of Medical Microbiology, 2008
Cladophialophora bantiana a dematiaceous fungus and a member of the family Phaeohyphomycetes, is primarily a neurotropic fungus causing central nervous system (CNS) infection. We report a case of a well preserved, young adult male presenting with a capsuloganglionic abscess caused by C. bantiana, a rare entity. Diagnosis was made based on the mycology and histopathology Þ ndings of the aspirate from the abscess through a burr hole. The patient responded clinically to amphotericin B.
Mycoses, 2009
Phaeohyphomycosis is a rare mycotic infection caused by various heterogenous groups of phaeoid (dematiaceous) fungi involving the skin and subcutaneous tissue. Common clinical manifestations are subcutaneous abscesses or cystic swellings. Here, we report a case of subcutaneous phaeohyphomycosis presenting as multiple asymptomatic cystic swellings over the hands and feet without any predisposing factors. Histopathology showed granulomatous inflammation and special stain with Grocott's methanamine silver stain revealed broad pigmented hyphae. Culture showed black-colored colonies identified as Exophiala jeanselmi. The patient was treated with surgical excision of the lesions.
Feline cutaneous phaeohyphomycosis due to Cladophyalophora bantiana
Journal of Feline Medicine & Surgery, 2002
A case of feline cutaneous phaeohyphomycosis due to Cladophyalophora bantiana is described. The cat was presented with breathing difficulty and a swollen, ulcerated nodule on the dorsal nose and left nostril. Histological examination of the nodule revealed a cystic granulomatous dermatitis characterised by neutrophils, macrophages and giant cells. Pigmented, yeast-like fungus cells and hyphal elements were easily identified in haematoxylin-eosin stained tissue sections. Cladophyalophora bantiana was isolated from a tissue specimen. This organism, primarily known to cause cerebral infection in humans and cats, only rarely causes cutaneous infection. Despite anti-fungal chemotherapy two relapses occurred. The cat was feline immunodeficiency virus-and feline leukemia virus-negative and even if the owner was unaware of trauma, the hypothesis of wound contamination is the most likely.
Fatal Systemic Phaeohyphomycosis in a Cat due to Cladophialophora bantiana
Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine, 2003
We report a case of fatal systemic mycosis in a 9-year-old cat. Diagnosis of phaeohyphomycosis was made by histology. Morphological and molecular identification of the fungus isolated from the lesions yielded the species Cladophialophora bantiana. This species is well known to be a neurotropic fungus causing cerebral pyogranulomatous lesions in humans. In this case, the lesions were widespread, distributed without the involvement of central nervous system. The origin of systemic manifestation is still unknown and no evidence of immunosuppression was found. It is the first feline case of C. bantiana infection reported in Europe.
Occurrence of Chromoblastomycosis due to Cladophialophora carrionii in a Libyan patient
In this study we report the second occurrence of chromoblasto-mycosis in Libya and identify the etiological agent. A 60 year old woman, presented with a history of asymptomatic left upper limb multiple skin lesions which had healed with scars. The lesions started at the site of a previous trauma to the left hand and after a few years had spread to involve the left forearm. Upon examination non-tender multiple erythematous, verrucous infiltrated plaques on the left hand and forearm were seen. Some lesions healed with atrophic and ivory coloured scar tissue. Skin biopsy with H&E stain demonstrated pseudoepitheliomatous hyperplasia of the epidermis, with micro abscesses and a diffuse lymph mononuclear inflammatory cell. In the upper dermis thick walled coloured fungal cells were seen inside and outside the giant cells. Fungal culture showed a slow-growing dark black velvety colony. The macro and micro morphology of Cladophialophora carrionii was noted.