Predictors of disease severity in drug reaction with eosinophilia and systemic symptoms (original) (raw)

Indian journal of dermatology, venereology and leprology, 2018

Abstract

Drug reaction with eosinophilia and systemic symptoms is an outcome of a complex interaction between specific drugs, certain herpesviruse types and the immune system of the affected individual and is characterized by an unpredictable course and recurrent flares even after withdrawal of the offending drug and administration of systemic steroids. To identify the predictors of disease severity in drug reaction with eosinophilia and systemic symptoms. After obtaining ethical clearance from the institutional ethics committee and a written informed consent from individual study participant, the first hundred patients who required inpatient care in Government Medical College, Kozhikode with drug reaction with eosinophilia and systemic symptoms from January 1 2011 were included in this study aimed to identify the predictors of disease severity in drug reaction with eosinophilia and systemic symptoms. Male-to-female ratio of the study group was 0.8:1. The presence of atypical cells in periph...

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