Effects of hyperuricemia on perinatal outcome in hypertensive disorder of pregnancy (original) (raw)
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Innovative publication, 2016
Background: Preeclampsia is one of the common conditions of unknown etiology which increases the risk of maternal and perinatal morbidity and mortality. According to some studies, serum uric acid lacks sensitivity and specificity as a diagnostic tool whereas another group of the researchers indicated uricemia as a predictor of preeclampsia in pregnant ladies. Objective: The present study was designed to assess whether serum uric acid can be used as a biochemical indicator or not, in pregnancy induced hypertensive (PIH) patients. Study period & Method: Total number of 98 PIH patients admitted in GMERS Medical College, Dharpur, from Dec 2013 to Feb 2015 were included in this study and 60 normal healthy pregnant ladies served as control. Serum uric acid levels were estimated using modified Trinder's test. Results: Out of the 98 cases mild preeclamspsia was 60(61.2±%), severe Preeclampsia 24 (24.5%) and eclampsia 14(14.3%). Serum Uric acid levels significantly increased with the severity of PIH, normal pregnant women (4.58±0.37), mild preeclampsia (5.32+0.40), severe preeclampsia (6.29±0.57) and eclamspsia (7.88±1.26). Out of these women with uric acid levels more than 5.5mg/dl was seen in 28(46.6%) mild preeclampsia, 19(79.2%) severe preeclampsia and 12 (85.7%) eclampsia. Maternal mortality was observed in 05(5.1%)PIH cases and out this 04(80) had uric acid level > 5.5mg/dl. Perinatal mortality was observed in 25 (25.1%) cases, out of these 19(76%) were stillbirths and 06(24%) were neonatal deaths. Out of the 25 perinatal deaths 18(72%) had uric acid level >5.5mg/dl. Conclusion: Serum uric acid level could be used as a biochemical indicator of preeclampsia/eclampsia and its complications.
Serum Uric Acid as a Prognostic Marker of Pregnancy induced Hypertension
Journal of SAFOG with DVD, 2012
Objectives: The purpose of the study is to determine the level of serum uric acid (s. uric acid) above which all complications occur, to analyze the maternal and fetal clinical and laboratory changes associated with elevated s. uric acid, and to determine whether s. uric acid can be used to predict maternal and fetal complications. Design: A retrospective study of hospital records was done on 80 women of pregnancy induced hypertension including both gestational hypertension and preeclampsia from January 2011 to March 2012 at Civil Hospital, Ahmedabad. The women were divided in two groups: with s. uric acid > 6 mg/dl/ s. uric acid < 6 mg/dl. Results: S. uric acid > 6 mg/dl was associated with maternal complications while s. uric acid > 5.5 mg/dl was associated with low birth weight babies. The mean creatinine and platelet count in two groups were significantly different at 5% level. Statistically significant elevation of s. uric acid was found in women of eclampsia. Conclusion: S. uric acid > 6 mg/dl is associated with increased maternal complications specially eclampsia and higher incidence of low birth weight. Thus, women with pregnancy induced hypertension with s. uric acid > 6 mg/dl should be offered termination of pregnancy.
Raised Uric Acid Level and Fetal Outcome in Hypertensive Disorders of Pregnancy
Nepal Journal of Obstetrics and Gynaecology, 2014
Aims: This study was done to find the relation of raised uric acid with fetal outcome in hypertensive disorders of pregnancy and to compare the fetal outcome with normal and raised uric acid level . Methods: This was a hospital based cross-sectional prospective comparative study done in Paropakar maternity and Women’s hospital conducted over three month period. Results: During the study period, a total of 126 cases of hypertensive disorders of pregnancy were identified among 3819 obstetric cases. The incidence of hypertensive disorders of pregnancy in this study was 3.3%. Fifty seven of them were found to have serum uric acid level <5.5 mg% (Group A), 43 of them were found to have serum uric acid level ≥5.5mg% (Group B). In those developing hyperuricemia 54.81% had mild hypertension, 40.91% had severe hypertension. Adverse perinatal outcome with serum uric acid level ≥5.5mg/dl had stillbirth in 7%, had low birth weight in 27.9%, 11.6 % were admitted in special care baby unit and ...
Indonesian Journal of Obstetrics and Gynecology, 2021
Objective: To asses the relationship between maternal serum uric acid level and severity of hypertensive disorders in pregnancy and perinatal outcomes.Methods: A cross sectional study was conducted at Persahabatan Hospital from January 2014 to December 2018. Subject were pregnant women with hypertensive disorder. Serum uric acid levels were taken from a venous blood sample at the time the patient came for delivery. The severity of hypertensive disorders in pregnancy were grouped into chronic hypertension, gestational hypertension, preeclampsia without severe feature, preeclampsia with severe feature, and preeclampsia with severe feature and organ involvement. The perinatal outcomes were the gestational age at birth, birth weight, and the first minute APGAR score. The relationship between maternal serum uric acid level and severity of hypertensive disorders in pregnancy and perinatal outcomes were analyzed using Mann Whitney and Kruskall Wallis test.Result: A total of 704 out of 880 ...
A Comparative Study of Serum Uric Acid Level in Normal Pregnancy, and Pregnancy Induced Hypertension
2011
Hypertension is one of the common complications met with in pregnancy and contributes significantly to the cause of maternal and perinatal morbidity and mortality. the study of uric acid in serum is an interesting problem especially in normal pregnancy and pregnancy induced hypertension (PIH). the present study was carried out at Physiology Department, shri M. P. shah Medical college and guru gobind singh Hospital, Jamnagar on total 80 subjects. Determination of uric acid was carried out by quantitative estimation on colorimetric method by enzymatic uricase method. results shows that serum uric acid levels in both the time (predelivery and postdelivery) were statistically significant in Pregnancy induced hypertension than normal pregnancy. Many patients had predisposing factor to development of preeclampsia like primigravida. It is also evident that severity of proteinuria increases with diastolic blood pressure and levels of serum uric acid did show a high positive correlation with the severity of Pregnancy induced hypertension in relation to hypertension and proteinuria 65% of patients of PIH
2018
Introduction: Hypertensive disorders of pregnancy is a broad spectrum entity complicating pregnancy from 2 nd trimester onwards with increasing prevalence leading to unfavourable maternal & foetal outcome Aim: 1. To study the accuracy of elevated S.uric acid levels as a predictor of hypertensive disorders of pregnancy& its complications. 2. To evaluate the maternal & perinatal outcome in relation to raised S. uric acid levels in women with PIH. Methodology: Hundred pregnant women in the age group of 20-40 yrs, in the 3 rd trimester of pregnancy, diagnosed as cases of pre ecclampsia, were included in the study after prior informed consent. The patients were investigated & followed up. Records of maternal & foetal outcome and the complications arising due to pre ecclampsia were maintained. The results were correlated with levels of S.uric acid and statistically analysed. Results:The study was conducted in two groups of sample size 50 each with S. uric acid> 6.0mg/dl in group A &<...
Uric acid as a biomarker for pregnancy induced hypertension
IP innovative publication pvt. ltd, 2020
Background: Pregnancy induced hypertension is the most common complication of pregnancy. It affects 5-7% of pregnant women. Pregnancy induced hypertension is characterized by vasospasm which is associated with platelet aggregation and reduced uteroplacental flow. In addition to these, altered renal function tests can also worsens the condition. This influences the maternal as well as fetal outcome. Aims: To prevent the complications of pregnancy induced hypertension and for proper management of these cases present study was conducted. Materials and Methods: The present study was conducted in 300 subjects grouped into 120 cases of normal pregnancy, 150 cases of pregnancy induced hypertensives, 30 cases of eclamptics and serum uric acid level was measured in these. Results and Discussion: elevated level of serum uric acid was seen with increase in gestation period and rise in diastolic blood pressure. The p- value was estimated by student t-test in different groups and was found to be< 0.001 which was highly significant and correlated. Conclusion: Hence Serum Uric acid is the significant and reliable indicator for pregnancy induced hypertension to prevent the fetal and maternal mortality and morbidity.
Pregnancy hypertension, 2017
Worldwide hypertensive disorder of pregnancy is major cause of maternal and perinatal morbidity, mortality. To study impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorder of pregnancy. Present study was conducted in Obstetrics and Gynecology Department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017). Total 110 pregnant women >-34weeks with hypertensive disorder of pregnancy were divided into three groups; Gestational hypertension (n = 35), Pre-eclampsia (n = 49), Eclampsia (n = 26). Maternal serum uric acid and its co-relation with perinatal outcome were assessed in each group. Of total 111 babies delivered to women with hypertensive disorder of pregnancy, 52 (46.85%) were preterm and 59 (53.15%) term. Of these; 43 (38.74%) were born healthy (APGAR > 7), 31 (27.93%) suffered minimal respiratory distress, 14 (12.61%) severe birth asphyxia and required ventilator support, of which two died, 19 (17.12...
Current Hypertension Reviews, 2019
Objective: To assess the relationship between maternal serum uric acid and severity of Hypertensive disorders of pregnancy in a rural tertiary care centre. Materials and Methods: Present study was conducted in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017) on 110 women admitted with a Hypertensive disorder of pregnancy (Gestational hypertension, Preeclampsia, Eclampsia) at ≥;34 weeks gestation. Maternal serum uric acid levels were compared in three groups in relation to disease severity, mode of delivery, maternal outcome. Results: Of total 110 women with a Hypertensive disorder of pregnancy; 35 (31.81%) had Gestational Hypertension, 49 (44.54%) preeclampsia and 26 (23.63%) had eclampsia. Mean±SD values for serum uric acid were 5.47±1.93 mg/dl in women with Gestational Hypertension; 6.72±2.15 mg/dl in Pre-eclampsia and 8.71±2.97 mg/dl in the eclamptic group. Of 110 women 34(97.14%) with gestational hype...
Asian Journal of Medical Sciences
Background: Uric acid, a metabolite of purine metabolism, is considered as a marker of hypertensive disorder of pregnancy (HDP) severity. An increase in serum uric acid level in pregnant mothers has been found to be associated with the disease severity. Aims and Objectives: The present study intended to evaluate the effect of serum uric acid level in maternal and neonatal outcome in cases of hypertensive disorders of pregnancy. Materials and Methods: This prospective and observational study was conducted on patients with HDP from December 2017 to April 2019. The study was conducted on 274 subjects who visited the Department of Obstetrics and Gynecology, HSK Hospital, Bagalkot. The participants were categorized into two groups according to their serum uric acid level (<6 mg/dL and ≥6 mg/dL). Serum uric acid was estimated by enzymatic colorimetric method. Maternal and neonatal outcomes were recorded. Follow-up was done till the discharge of the mother and child from the hospital. D...