Effects of drugs on water permeability of erythrocyte membranes (original) (raw)

Abstract

The method of NMR relaxation with the manganese doping has been applied to study changes of water permeability of red blood cell membranes affected by various concentrations of chlorhexidine diglu conate and dimephosphone. It is shown that both investigated substances suppress the water permeability of the red blood cell membrane in a dose dependent manner. Half maximum inhibitory effect of studied sub stances was reached at the concentrations of 9 µM of chlorhexidine and 400 µM of dimephosphone.

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