Progress in In-situ Gelling Ophthalmic Drug Delivery System (original) (raw)
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Research progress of in-situ gelling ophthalmic drug delivery system
Asian Journal of Pharmaceutical Sciences, 2018
Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (< 5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system.
In-Situ Gelling Ophthalmic Drug Delivery System: An Overview
Int. J. Pharm. Pharm. Sci, 2010
Eye is the most vital organ of body. The usual ophthalmic dosage forms are account for 90% of currently accessible ophthalmic formulations. The major trouble encountered is quick precornel drug loss. To improve ophthalmic drug bioavailability, there are considerable efforts directed towards newer drug delivery systems for ophthalmic administration. Newer research in ophthalmic drug delivery systems is directed towards a amalgamation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. There are various new dosage forms like insitu gel, collagen shield, minidisc, ocular film, ocusert, nanosuspension, nanoparticulate system, liposomes, niosomes, dendrimers, ocular iontophoresis etc. Conventional delivery systems often result in poor bioavailability and therapeutic response because high tear fluids turn over and dynamics cause rapid elimination of the drug from the eyes. So, to overcome bioavailability problems, ophthalmic in situ gels were developed.
Revolutionizing ocular drug delivery: recent advancements in in situ gel technology
Bulletin of the National Research Centre
Background Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug. The main body of the abstract Among drug delivery modalities, ocular drug administration requires careful study and parameter assessment. This is because the eyes are sensitive and require careful care. Conventional ocular administration techniques quickly eliminate formulated compounds, minimizing epithelial interaction. This review covers polymers used in ocular medication delivery, their uses, and their drawbacks. The in situ gelling mechanism converts liquid formulations into gels under certain physiological or environmental conditions. When they contact the ocular surface, in situ ocular gels undergo this transformation for medication administration. Different mechanisms drive this change, depending on the gel's formulation and desired properties. Temperature-, pH-, and ion-ind...
A Review on in Situ Gelling System for Ophthalmic Drug Delivery
Current research in pharmaceutical sciences, 2022
Ophthalmic drug delivery systems are both fascinating and problematic due to the normal physiological properties of the eyes, which restrict ocular product bioavailability. The development of novel ocular dosage forms for current drugs in order to enhance efficacy and bioavailability, as well as patient compliance and convenience, has become a major focus in the pharmaceutical business. Ocular In-situ gelling systems are a novel type of eye drug delivery systems that begin as a solution but rapidly convert into a thick gel when implanted or inserted into an ocular cavity where active pharmaceuticals are continually delivered. This sol-to-gel phase conversion is influenced by a range of variables, including variations in pH, the presence of ions, and temperature fluctuations. Posttransplantation gel is chosen for its viscosity and bio adhesive qualities, which prolongs the gel's presence in the ocular area and also ensures that the medicine is released slowly and continuously, in contrast to typical eye drops and ointments. This article provides an overview of situ gels, their numerous techniques of gelling, the many types of polymers utilized in situ gels, their gel-based methodologies, and the polymeric testing of situ gels.
In Situ Gels-A New Trends in Ophthalmic Drug Delivery Systems
2015
Ophthalmic drug delivery is one of the most interesting and challenging endeavor facing the pharmaceutical scientist. The conventional ocular drug delivery systems like solutions, suspensions, and ointments show drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision respectively so there was a need for developing advanced drug delivery system. In situ forming polymeric formulations were developed to overcome the conventional drug therapy drawbacks these systems are in solution form before administering in the body, but once administered these systems undergo gelation. The formation of gels depends on factors like change in a specific physico-chemical parameter (pH, temperature, ion-sensitive) by which the drug gets released in a sustained and controlled manner. These systems were evaluated for drug content, clarity, pH, gelling capacity, viscosity, in vitro drug release studies, texture analysis, sterility testing , isotonicity evaluat...
REVIEW OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY
The traditional dosage form has many limitations due to factors such as naso-lacrimal drainage & shorter contact time. Ophthalmic in-situ gelling system composed of environmentally sensitive polymers that will be structurally changed in response to small changes in specific condition. Environmental pH, temperature, & ionic strength, Response to environmental changes, the in- situ are liquids when installation into the eyes and then undergo rapidly gelation into the Cul- de-sac of the eye to form visco-elastic gel. This tends to increase ocular residence time and decreases Precorneal drug loss as a result. The goal of this study is to prepare and evaluate In- situ Gel for ocular drug delivery by using mucoadhesive polymers to increase ocular residence time and minimize Precorneal drugs loss of given formulation. Keywords: Ocular Drug Delivery, In-situ Gelling System, Conjunctivitis.
Journal of Biological & Scientific Opinion, 2013
Ophthalmic drug delivery is one of the most interesting and challenging endeavours facing the pharmaceutical scientists, the major problem encountered to pharmaceutical scientist is rapid precorneal elimination of the drug, resulting in poor bioavailability and therapeutic response, because of high tear fluid turn over and dynamics. Newer research in ophthalmic drug delivery system is directed towards amalgamation of several drug delivery technologies which helps to extend the contact of the vehicle at the surface of the ocular system and slows down the removal of the drug. In situ-forming gels are liquid upon instillation and undergo phase transition in the ocular cul-de-sac to form visco-elastic gel and these gels provide a response to environmental changes. In the past few years, an impressive number of novel temperature, pH, and ion induced in situ forming systems have been reported for sustained ophthalmic drug delivery. This review includes polymeric systems used in various temperatures, pH, and ion induced in situ gel formulation to achieve prolonged contact time of drugs with the cornea and increase their bioavailability.
TO DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY
In-situ Gel for ocular drug delivery is prepares by using mucoadhesive polymers to increase ocular residence time and minimize precorneal drugs loss of given formulation. Ophthalmic in-situ gelling system composed of environmentally sensitive polymers that will be structurally changed in response to small changes in specific condition like Environmental PH, temperature, & ionic strength. In response to environmental changes, installed liquid in-situ rapidly undergoes gelation into the Cul- de-sac of the eye to form visco-elastic gel. This tends to increase ocular residence time and decreases Precorneal drug loss as a result. KEYWORDS- In-situ Gelling System, Ketorolac Tromethamine, Sodium Alginate, HPMC K4M, Benzalkonium Chloride,
In-Situ Ophthalmic Gels for the Treatment of Eye Diseases
Topical administration of a drug in the conjunctival cul-de-sac is the treatment of choice for diseases of the anterior segment of eye. Development of ophthalmic drug delivery systems has always been challenging because of the drawbacks with this route, like non-productive absorption, drainage, induced lacrimation, tear turn over, impermeability of drugs to cornea. New approaches have been investigated for delivery of drugs to the eye by means of polymeric delivery of ophthalmic drugs to the pre-and intra ocular tissues, have been attempted to increase the bioavailability and the duration of therapeutic action of ocular drug. Certain new approaches to increase the ocular bioavailability, duration of the drug action and to reduce the undesirable side effects are by using drug carriers that regulate pre-corneal drug loss and improve the corneal contact time. Many of these systems prolong ocular bioavailability but do not control drug penetration through the cornea. Consequently, the d...
Ocular in Situ Gels : Development , Evaluation and Advancements
2015
The ocular drug delivery system is considered as crucial and challenging as the delivery of drug is quite difficult. Moreover, the conventional opthalmic formulations exhibit a short pre-corneal residence time and poor bioavailability . Various attempts have been made towards the development of stable sustained release in-situ gels. Newer research in ophthalmic drug delivery systems is directed towards a incorporation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. This is a review on ocular in situ gels, delivery systems, evaluation and application.