Protective effect ofSpirulina platensisagainst aluminium-induced nephrotoxicity and DNA damage in rats (original) (raw)

Toxicological & Environmental Chemistry, 2015

Abstract

The protective effect of Spirulina platensis (SP) powder against aluminium-induced nephrotoxicity and DNA damage in rats was studied. Male rats receiving daily 40 mg/kg b.wt. aluminium chloride (AlCl3) orally had increased serum levels of urea and creatinine, up regulated kidney injury molecule-1 and tissue inhibitor of metalloproteinase-1 genes, down regulated catalase and glutathione peroxidase genes, and increased all parameters of kidney DNA damage using comet assay. Treatment with SP alleviated all AlCl3-induced effects of toxicity, especially when the animals were pre-treated.

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