Bacillus thuringiensis Parasporins and Their Use in Controlling Cancer Cells (original) (raw)

Parasporins are Cry proteins produced by Bacillus thuringiensis ( Bt ) strains during sporulation processes and notable for targeting the cancer cells with their unique cytotoxicity mechanism without exerting haemolytic effect on normal cells. Parasporins are specifically produced by Bt strains with non-insecticidal effect. Although the studies on parasporins go back to the 1970s, comprehensive scan about the cytotoxicity of parasporins was performed by Mizuki and colleagues. Considering that these proteins exhibit selective toxicities on human cancer cell lines but not on normal cells, detailed studies about the mode of action of anti-cancer effect was investigated in several countries. Specificity and abundance of parasporin producing Bt species in nature brought them into an important position in terms of developing anti-cancer agents. Parasporins are classified into six groups by the committee of parasporin classification and nomenclature as parasporin-1 (PS1), PS2, PS3, PS4, PS...

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