The Prevalence of Growth Variations Among Pediatric Celiac Disease Patients at the Time of Diagnosis (original) (raw)
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Body mass index is not a reliable tool in predicting celiac disease in children
BMC Pediatrics, 2014
Background: Untreated celiac disease is traditionally believed to be associated with malabsorption and underweight. However, studies describing body mass index (BMI) in individuals at the time of diagnosis have shown contradictory results. We investigated the differences in weight, height, and BMI in 12-year-old children with screening-detected celiac disease compared to their healthy peers. Methods: In a population-based screening study of 12,632 12-year-old children, blood samples were analyzed for markers of celiac disease. Children with elevated markers were referred for a small bowel biopsy. Weight and height were measured in 239 out of 242 children with screening-detected celiac disease (57.3% girls) and in 12,227 children without celiac disease (48.5% girls). BMI was categorized according to the International Obesity Task Force. Age-and sex-specific cut-off points for underweight, normal weight, and overweight were used. Results: Children with celiac disease weighed less and were shorter than their peers (median weight 45.2 kg, interquartile range (IQR) 40.2-52.2 kg vs. 47.0 kg, IQR 41.1-54.4 kg, respectively, p = 0.01; median height 156.5 cm, IQR 151.0-162.0 cm vs. 157.5 cm, IQR 152.0-163.0 cm, respectively, p = 0.04). In comparing those with celiac disease to their healthy peers, 4.2% vs. 5.2% were underweight, 82.0% vs. 72.8% were normal weight, and 13.8% vs. 21.9% were overweight, respectively. There was no association between being underweight and the risk of having undiagnosed celiac disease (Odds ratio (OR) 1.3, 95% CI 0.7-2.4), but the risk was significantly lower among overweight children (OR 0.56, 95% CI 0.4-0.8). Median BMI was slightly lower among the children with screening-detected celiac disease compared to their healthy peers (18.6 kg/m 2 , IQR 17.1-19.8 kg/m 2 vs. 18.8 kg/m 2 , IQR 17.2-21.1 kg/m 2 , respectively, p = 0.05), but most of the celiac disease cases had a normal BMI. Conclusions: At a population level, children with celiac disease weigh less, are shorter, and have a lower BMI compared to their peers without celiac disease, and this emphasizes the importance of early recognition and treatment of the condition. However, at an individual level, growth parameters are not reliable in establishing the diagnosis.
Background Celiac disease (CD) is an autoimmune condition triggered by gluten ingestion in genetically predisposed individuals. It can lead to chronic bowel inflammation and cause serious adverse consequences on children's health and development, including failure to thrive (FTT) or impaired growth. Currently, data on pediatric CD in Kuwait are limited. Objective We aimed to assess the nutritional status of children and adolescents with CD in Kuwait and investigate the nutritional deficiencies and sociodemographic factors associated with growth stunting in this population. Methods This case-control study included aged 3–18 years. Cases (n = 77) were diagnosed with CD using IgA-anti tissue transglutaminase (IgA TTG antibodies) and duodenal biopsy and compared to a healthy control group (n = 33). Nutritional status was evaluated using demographic and clinical characteristics, anthropometric measurements, and biochemical parameters. Univariate and multivariate logistic regression m...
2019
Background: Celiac disease (CD) is a lifelong disorder with gluten-induced manifestations in different organs especially growth. Gluten free diet (GFD) is required to achieve remission and prevent abnormal growth. Study reports on growth of children with celiac disease on long-term GFD are not consistent. Objective: We evaluated the effect of GFD on growth of children with the classical form of CD (diagnosed by serology and small intestine mucosal biopsy) on log-term GFD (>2 years). Methods: We studied growth parameters (weight gain/day, BMI and BMI-SDS, height growth velocity, Ht-SDS) and lab data in 30 prepubertal children, aged 7.4±2.6 years, with CD, who were on GFD since the age of 3.2±1.6 years of age (>2 years on GFD) for duration of 1 year. The anthropometric data of 30 randomly selected normal, age and sex matched, children were used as control. Lab investigations of CD children included complete blood count (CBC), renal and liver functions (aspartate transaminase - A...
Archivos Argentinos de Pediatria
Introduction. The objective of this study was to evaluate the relation between age at diagnosis and compliance to gluten free diet (GFD) on growth in children with celiac disease and the factors that influenced compliance to GFD. Population and Methods. Celiac disease (CD) patients with villous atrophy followed in our hospital between January 2015 and January 2017, were included. They were classified according to diagnosis age and GFD compliance. Patients' anthropometric characteristics at diagnosis and follow-up were compared. Results. There were 73 patients with 10.4 ± 4.5 years of average age, 35 (47.9%) patients had a short stature at diagnosis, the ages of patients who had short stature (7.8 ± 4.2 years) were higher than those who did not (5.1 ± 4.3 years) (p= 0.005). At diagnosis, 33 (45.2%) patients were aged ≤6 years, 40 (54.8%) were aged >6 years. The height and weight z-scores of patients who were diagnosed at >6 years of age were significantly lower than those who were diagnosed ≤6 years of age both at diagnosis (p= 0.01 and 0.04) and at last control (p= 0.001 and 0.001), respectively. Forty-five (61.6%) patients were fully compliant with GFD. In comparison of anthropometric data in terms of GFD compliance, the increase in BMI and weight z-score in the fully compliant group was found to be significantly higher when compared with the other group. Conclusions. Delay in CD diagnosis negatively affected both the height and weight and other growth parameters. GFD compliance positively affected the patients' all growth parameters, especially weight and BMI z-score.
Celiac Disease Among Children Presented with Unexplained Short Stature
2020
Introduction: Celiac disease is a chronic autoimmune condition, in genetically susceptible persons, perpetuated by the ingested gluten from cereals, wheat and barley, its clinical spectrum is broad, varies from absence of symptoms to gastrointestinal (classic) and/or extra intestinal (non-classic) symptoms, patients without symptoms may have latent or silent celiac disease, because celiac disease can be atypical or even clinically silent, many patients remain undiagnosed and at risk for the long-term, sometimes serious complications of untreated celiac disease. Short stature is the most commonly encountered extra-intestinal (non –classical) symptoms of CD in children, being found in roughly one-third of all new pediatric celiac diagnoses, while it can be directly related to malabsorption of nutrients, it should completely reverse once a child is strictly adherent to Gluten free diet. Aim of the work: The goal of this study was to screen for coeliac disease in Egyptian children with...
Canadian journal of gastroenterology & hepatology
Celiac disease (CD) is a common autoimmune disorder with an increasing prevalence, including in ethnic minorities. To report the frequency of CD diagnosis in ethnic minorities presenting to a Canadian pediatric celiac clinic and to determine whether ethnic differences exist at diagnosis or follow-up. Patients with biopsy-proven CD diagnosed at a multidisciplinary celiac clinic between 2008 and 2011 were identified through the clinic database. Data at referral, and six-month and 12-month follow-ups were collected. These included demographics, self-reported ethnicity, symptoms, anthropometrics and laboratory investigations, including serum immunoglobulin antitissue transglutaminase (aTTG). A total of 272 patients were identified; 80% (n = 218) were Caucasian (group 1) and 20% (n = 54) were other ethnicities. South Asians (group 2) comprised 81% (n = 44) of the minority population. No differences in age or sex were found between the two groups. Group 1 patients presented more often wit...
Growth changes after gluteen free diet in pediatric celiac patients: a literature-review
Acta Bio Medica : Atenei Parmensis, 2018
Background: Celiac disease is an auto-immune disorder characterized by clinical manifestations that appear in genetically predisposed subjects after gluten ingestion. In the last years, there has been a progressive change in clinical manifestations. Our aim was to evaluate the nutritional status of children with celiac disease at diagnosis and how the gluten-free diet (GFD) influences their growth. Methods: A search on PubMed/Medline was performed using “celiac disease”, “body mass index” and “children” as key words. Medline, Scopus, PubMed publisher and Google Scholar were searched as well. We selected clinical studies describing the nutritional status of patients before and after GFD using indicators like height, weight, BMI, skeletal age. We excluded papers referred to adult population or in which other diseases were related to celiac disease. Also literature-reviews were excluded. Results: From 1999 to 2018, 10 studies were found. Overall, 1383 patients in pediatric age were eva...
Screening rules for growth to detect celiac disease: A case-control simulation study
BMC Pediatrics, 2008
Background: It is generally assumed that most patients with celiac disease (CD) have a slowed growth in terms of length (or height) and weight. However, the effectiveness of slowed growth as a tool for identifying children with CD is unknown. Our aim is to study the diagnostic efficiency of several growth criteria used to detect CD children.
2021
Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinical and laboratory improvement. This the study was designed to determine the role of dietary compliance and adherence effect of gluten free diet (GFD) among celiac disease patient. Thirty-six patients with Celiac disease (CD) who were confirmed by duodenal biopsy included in the study. The mean age of patients at diagnosis was 7.94. 69.2% of the patients aged ≤6 year were compliers, 56.5% of patients aged > 6years were compliers. 41.7% of GFD complaint patients were stunted. however,30.4% of GFD non-compliant group were stunted as well. FTT was observed in 26% and 34.8% of the GFD compliant group and GFD non-compliant group respectively. complications found to be more common in GFD non complaint gr...