Diagnostic Immunohistochemistry in ovarian metastases (original) (raw)
Related papers
Tumores metastásicos de ovario: revisión de casos clínicos
Clínica e Investigación en Ginecología y Obstetricia, 2005
Metastatic tumours constitute approximately 15% of malignant tumours of the ovary. The most frequent primary tumours derive from the gastrointestinal tract, breast and endometrium. We review the metastatic ovarian tumour diagnosed in our Service in the last five years. The average age at diagnosis was 56.96 years. Two thirds were of non-gynaecological origin and the rest derived from the gynaecological organs and the breasts. Half of the patients presented with a gastrointestinal primary. The majority of the metastasis were diagnosed afterwards, were 5 cm or less in size and affected only one ovary. The predominant component of the tumours was solid. The clinical history of these patients was from nothing to pain and an increase in abdominal size. Treatment in all cases was surgical with additional chemotherapy and/or radiotherapy. At present, one third of the women have died.
Ginecología y obstetricia de México, 2012
Ovarian steroid cell tumors represent less than 0,1% of all ovarian tumors. These tumors normally appear in adult women, producing virilization due to the secretion of testosterone. They may have occasionally a malignant behavior, but when they present during adolescence. We report the case of a 49-year-old woman with an ovarian steroid cell tumor concurrent with an ovarian fibrothecoma, which was an incidental finding, remaining the patient asymptomatic before the diagnosis. Several aspects of the symptomatology, diagnosis and treatment are discussed in this article.
[Chemotherapy in germinal and epithelial ovarian cancer]
Ginecología y obstetricia de México, 2000
Generically, ovarian cancer represents a group of tumors with diverse biological and clinical behavior. Thus, germinal cells ovarian tumors, in the vast majority of patients are successfully treated utilizing traditional based on cisplatin chemotherapy. Epithelial ovarian cancer, that accounts for 90% of these cases, although sensitive to chemotherapy has not shown satisfactory results. In the search better tumoral response in the treatment of epithelial ovarian cancer new drugs have surged that promise good results, including docetaxel, topotecan and gemcitabine, both as single agents, or in combination with other therapies utilizing monoclonal antibodies.
Investigación básica del cáncer de ovario
2018
ciencia volumen 69 50 número 1 nFi gura 3. Ratón nu/nu con implante subcutáneo de células cancerígenas de ovario SKOV-3 (figura original elaborada con resultados obtenidos en el laboratorio de la doctora Patricia Talamás Rohana).
Gaceta médica de México
In the workup of tumors of unknown primary origin in women, a frequent consideration is breast carcinoma, because it is common and may initially present as metastasis. Describe and compare the immunohistochemical profile of hormonal receptors (estrogen receptor and progesterone receptor) and GCDFP-15 in lymph node metastatic breast carcinoma according the histological grade. Retrospective study analyzing 30 patients with identified primary breast cancer and lymph node metastasis. The cases were divided in three groups: grade I (well differentiated), grade II (moderately differentiated) and grade III (poorly differentiated). We used three antibodies (estrogen receptor, progesterone receptor and GCDFP-15) in the lymph node and compare the expression according the histological grade. In metastatic lymph node from grade I breast carcinomas the hormone receptors were 100% positive and GCDFP-15 was 80% positive. In grade II, estrogen receptor and progesterone receptor were positive in 90 ...
Immunohistochemistry in breast cancer. Tool needed today
Medisur, 2018
Molecular studies development in breast cancer has provided arguments to establish subclassifications of diagnostic and therapeutic importance, which are bringing to the daily practice the desirability of a patients personalized therapy, to better identify the type of neoplasia. Most current studies seek to phenotypically relate these subtypes to the classic factors reported in the breast cancer anatomopathological report, using conventional hematoxylin and eosin techniques. Immunohistochemistry is a reliable tool that allows subclassification of these neoplasms in different categories using markers, which can establish necessary parameters in diagnosis and prognosis. In this paper the main immunohistochemical markers used in Cienfuegos are presented as well as their usefulness.
[Management of ovarian metastasis from a lobular breast carcinoma]
Ginecología y obstetricia de México, 2014
Ovarian metastatic breast cancer is infrequent and usually is originating from lobular carcinomas. It was found that the risk of developing an ovarian neoplasm is approximately doubled in women with a history of breast cancer. The finding of an adnexal mass in these patients involves a particular concern and requires a study. We report a case of a 67-year-old female diagnosed of an infiltrating lobular breast carcinoma. It is done lumpectomy and an axillary dissection of lymph nodes resulting 2 of 13 lymph nodes positives. She was treated with chemotherapy and hormone treatment staying the disease in remission for years. After she was admitted with malignant pleural effusion and pathological costal fracture. The ultrasound shows an increase of size of annexes and a CA125 and CA15.3 increased in the analysis. Bilateral oophorectomy was performed. The pathology was consistent with lobular breast carcinoma. Subsequently another income was required because of disease progression. Curren...
Fecha de recepción en versión modificada: 02-06-2012 Fecha de aceptación: 03-06-2012 resumen antecedentes: en el estudio de tumores de sitio primario no conocido en mujeres, una consideración frecuente es carcinoma mamario, porque puede presentarse como metástasis. objetivo: describir y comparar el patrón inmunohistoquímico de los receptores hormonales (receptor de estrógenos [RE] y receptor de progesterona [RP]) y GCDFP-15 en carcinoma mamario metastásico en ganglio linfático según el grado histológico. Métodos: estudio retrospectivo donde se analizan 30 casos de carcinoma mamario con metástasis ganglionar, divididos en tres grupos: grado I (bien diferenciado), grado II (moderadamente diferenciado) y grado III (poco diferenciado). Se utilizaron tres anticuerpos (RE, RP y GCDFP-15) en el ganglio linfático y se comparó su expresión según el grado histológico. resultados: en ganglios linfáticos con metástasis de carcinoma mamario grado I los receptores hormonales fueron positivos en el 100% y GCDFP-15 en el 80%. En grado II, el RE y el RP fueron positivos en el 90 y 40%, respectivamente, y GCDFP-15 en el 80%. En grado III, el RE y RP fueron positivos en el 30 y 50%, respectivamente, y GCDFP-15 en el 60%. Conclusiones: la expresión inmunohistoquímica de receptores hormonales y GCDFP-15 en carcinoma mamario metastásico está relacionada con el grado histológico en la mama. Palabras clave: Carcinoma de mama. Receptor de estrógenos. RP. GCDFP-15. Metástasis.