Potentiating effect of Phragmanthera capitata extract in haematopoietic activities in Wistar rats (original) (raw)

Aims: Garcinia kola is used in West African countries for the treatment of various ailments such as cough, tooth decay, asthma and menstrual cramps. The inhibitory effect of Garcinia kola seed extract (GKE) on drug-induced contractions was studied on iliac smooth muscle preparations of guinea pig to ascertain the validity of the use of Garcinia kola in traditional medicine and to elucidate its possible mechanism of action. Place and Duration of Study: The study was done in Post Methodology: The antispasmodic influence of GKE (0.02 -1 mg/ml) on acetylcholine, histamine and potassium chloride -induced contractions were carried out. The effect of GKE in a Ca 2+ -free Tyrode medium and in the presence of adrenergic antagonists was also investigated.