Antihypoglycemic and Antihypolipidemic Activities of Ethanolic Roots Extract of Crossopteryx Febrifuga in Alloxan-Induced Diabetic Rats (original) (raw)

Mintage Journal of Pharmaceutical and Medical Sciences, 2013

Abstract

Objective: The study investigated the activities of antihypoglycemic and antihypolipidemic of ethanolic roots extract of Crossopteryx febrifuga (CF) in alloxan-induced diabetic rats. Methods: Twenty male albino rats were randomly distributed to four groups; I, II, III and IV with each consisting of five animals received extracts as follows: Group I, C.febrifuga (500 mg/kg bwt); Group II, C.febrifuga (250 mg/kg bwt); Group III, C. febrifuga (100 mg/kg bwt); Group IV, 0.5 ml (2% w/v) acacia solution and served as control. After 30 min, the animals were each administered orally with 20% (w/v) glucose at a dose of 0.5ml /100 g bwt. Blood glucose levels were then monitored at 30, 60, and 120 min. intervals and reported as the average glucose level of each group. Twenty- Five (25) Albino rats were randomly divided into five (5) experimental groups: control, diabetic, standard drug (glibenclamide) and C. febrifuga (375 and 500 mg/kg bwt) treated diabetic groups. The animals in four out of five groups were fasted for 18 h and were made diabetic by injecting with a single dose of alloxan (ALX) 150 mg/kg. Blood was collected on days 0, 5, 10 and 15 for glucose estimation and day 15 for lipid profile assay. Results: A significant reduction in postprandial sugar level was observed after 60 min in all treatments. Alloxan-induced diabetic rats without treatment showed significant increases ( p < 0.05) in the levels of blood glucose, triglycerides, total cholesterol, low density lipoprotein LDL-cholesterol while the high density lipoprotein HDL-cholesterol level were significantly decreased ( p< 0.05) compared to normal rats. In addition, the diabetic rats treated with the CF and glibenclamide showed significant decrease ( p < 0.05) in both blood glucose, TG and LDL- cholesterol levels and a significant decrease ( p < 0.05) in HDL-cholesterol level compared to diabetic untreated rats. Conclusion: The ethanolic roots extract of Crossopteryx febrifuga (CF) possesses potential hypoglycemic and hypolipidemic activities in alloxan-induced diabetic rats.

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