Etude structurelle en Microscopie Confocale Raman du cartilage produit par ingénierie tissulaire (original) (raw)

Articular cartilage is connective tissue, non-innervated and non-vascularized, that covers the ends of the bones within the joints. The high stresses to which the cartilage is subjected often lead to the alteration of the articular matrix. Defects in articular cartilage are generally associated with pain and loss of joint mobility, and have an impact on quality of life, including physical, social and economic well-being. Due to the lack of spontaneous regeneration or healing of cartilage, the use of tissue engineering techniques appears to be a promising avenue to address the clinical needs of patients with osteoarthritis and temporomandibular joint disorders (TMD). To optimize cartilage tissue engineering, non-invasive, non-destructive, high-resolution (nanometric) techniques are needed to evaluate the quality and structural arrangement of cartilage manufactured in vitro. The objective of our study was to follow the maturation of artificial cartilage under mechanical loads with inn...