Transgenerational Benefits of Soy Isoflavones to Bone Structure in the CD-1 Mouse Model (original) (raw)

Nutritional Influences on Bone Health, 2016

Abstract

Diet during early life can set a lifelong trajectory for better bone health and is termed ‘nutritional programming’. Using the CD-1 mouse model, exposure to soy isoflavones during neonatal life resulted in higher bone mineral density, improved bone structure, and greater bone strength of femurs and lumbar spine, and protected against ovariectomy-induced bone loss. The objective of this study was to determine if there are transgenerational benefits of isoflavones to bone health. Benefits to bone structure at femur neck but not at the femur midpoint, distal femur and LV3 were transferred to offspring. Understanding the mechanisms of this transgenerational inheritance requires further study.

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