Prevalence of colorectal neoplasms in young, average risk individuals: A turning tide between East and West (original) (raw)
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Risk of Advanced Colorectal Neoplasia According to Age and Gender
PLoS ONE, 2011
Background: Colorectal cancer (CRC) is one of the leading causes of cancer related morbidity and death. Despite the fact that the mean age at diagnosis of CRC is lower in men, screening by colonoscopy or fecal occult blood test (FOBT) is initiated at same age in both genders. The prevalence of the common CRC precursor lesion, advanced adenoma, is well documented only in the screening population. The purpose of this study was to assess the risk of advanced adenoma at ages below screening age.
Proportionate increase in incidence of colorectal cancer at an age below 40 years: An observation
Journal of Cancer Research and Therapeutics, 2006
Aim: Colorectal cancer is particularly a disease affecting individuals above 40 years of age and 90% of cases occur in persons over the age of 50. Genetic and familial factors, viz, HNPCC and FAP, contribute to less than 20% and environmental or acquired factors are the cause of the rest. The aim of this study is to find out the relative proportion of patients <40 years of age affected by this disease, registered in our institute. Materials and Methods: Colorectal cancers registered in the calendar years of 2003 and 2004 in our institute were analyzed in this study. Data from Population Based Cancer Registry (P.B.C.R.) for Bangalore, Mumbai, Delhi and Chennai for the year 1988 were taken for comparison. Results: The results show that our institute's figures exceed the generally accepted figure for 'incidence of the disease below the age of 40 years' by less than 10% of both the total incidence of the disease and those of P.B.C.R. for Bangalore, Mumbai and Chennai. The corresponding figure for females in Delhi P.B.C.R. shows a little similarity to our institute's figure. Conclusion: This observation indicates a changing pattern of colorectal cancer occurrence. This change may be a regional one or may be a result of genetic or environmental changes.
Background: Colorectal cancer (CRC) is one of the prime causes of mortality around the globe, with a significantly rising incidence in the Middle East region in recent decades. Since detection of CRC in the early stages is an important issue, and also since to date there are no comprehensive epidemiologic studies depicting the Middle East region with special attention to the average risk group, further investigation is of significant necessity in this regard. Aim: Our aim was to investigate the prevalence of preneoplastic and neoplastic lesions of the colon in an average risk population. Materials and Methods: A total of 1,208 eligible asymptomatic, average-risk adults older than 40 years of age, referred to Firuzgar Hospotal in the years 2008-2012, were enrolled. They underwent colonoscopy screening and all polypoid lesions were removed and examined by an expert gastrointestinal pathologist. The lesions were classified by size, location, numbers and pathologic findings. Size of lesions was measured objectively by endoscopists. Results: The mean age of participants was 56.5 ± 9.59 and 51.6% were male. The overall polyp detection rate was 199/1208 (16.5 %), 26 subjects having non-neoplastic polyps, including hyperplastic lesions, and 173/1208 (14.3%) having neoplastic polyps, of which 26 (2.15%) were advanced neoplasms .The prevalence of colorectal neoplasia was more common among the 50-59 age group. Advanced adenoma was more frequent among the 60-69 age group. The majority of adenomas were detected in the distal colon, but a quarter of advanced adenomas were found in the proximal colon; advance age and male gender was associated with the presence of adenoma. Conclusions: It seems that CRC screening among average-risk population might be recommended in countries such as Iran. However, sigmioidoscopy alone would miss many colorectal adenomas. Furthermore, the 50-59 age group could be considered as an appropriate target population for this purpose in Iran.
International Journal of Advances in Medicine
Background: Colorectal cancer (CRC) is a common cancer worldwide with significant geographical variation in its incidence. CRC among young adults is not well reported in Indian patients.Methods: A retrospective study was performed to determine the burden and to analyze the clinicopathological characteristics of newly diagnosed CRC among younger adults (<50 years). Chi-square method was used to analyze the clinicopathological characteristics. P≤0.05 was considered statistically significant.Results: CRC among younger adults comprised 40.3% of total patients median age of 40 years at diagnosis, was associated with predominantly male patients with male: female ratio of 1.8:1, positive family history, lesser co-morbidities (p=0.000), majority left sided primary tumor with left: right ratio of 4.6:1, more frequent high grade histology compared to older age group (p=0.000), advanced primary tumor and nodal metastasis. Approximately one third patients had distant metastasis at diagnosis ...
Acta Gastroenterológica Latinoamericana
Introduction. It is uncertain whether starting screening at 45 years old would improve colorectal cancer prevention and currently available studies in adults younger than 50 years old are limited. Aim. To evaluate the adenoma detection rate at different age intervals. Materials and methods. Colonoscopies performed on adult outpatients were analyzed. Adenoma detection was recorded in the total population and in patients with screening indication. First, patients were divided into two groups: 50 years or older (group A) and younger than 50 years (group B). Then, we analyzed the different age segments: up to 44 years (group 1) 45 to 49 (group 2), 50 to 54 (group 3), and 55 or older (group 4). Results. A total of 5090 patients were included, 2877 with indication for screening. Patients were divided as follows: 3883 in group A, 1207 in group B, 811 in group 1, 396 in group 2, 749 in group 3 and 3134 in group 4. In the total population, adenoma detection was 20.5%: 23.5% in group A, 10.5%...
Age wise distribution of colorectal cancer: An institutional observational study
IOSR Journal of Dental and Medical Sciences, 2017
Background: Overall, the incidence of colorectal cancer appears to be stable or diminishing. However, based on our regional cancer institute's datas, we have observed the increasing incidence of colorectal cancer in patients ≤40 age. The aim of this study was to verify the rising trend, clinico-pathological features and survival in colorectal cancer in patients ≤40,in comparison to patients >40 age. Materials and methods: A retrospective study was conducted to review all patients≤ 40 age and more than 40 year of age separatly with a diagnosis of colorectal cancer from January 2004 to December 2012. Results: Young patients were 24.17% of total 1096 colorectal cases. In young patients 60.37% were male and 39.63% were female. 9% young had family history & only 8% had history of alcohol intake. Onset of symptoms to reaching diagnosis period is longer in younger patients.(Range 3 months to 1 year in young, while 1 months to 6 months in older). Higher pathological T stage was seen in the younger age group when compared with patients above 40 years. Also the younger age group showed more advanced N stage when compared with patients above 40 years. With final TNM staging, in younger age group 66% were in stage IV and 30% were in stage III. Eighty percent of all young cancer deaths were within 22 months (from 8months to 22 months). Conclusion: Above results show the aggressive nature and late diagnosis of carcinoma colorectal in young. These data highlight a need for thorough evaluation of young with colorectal symptoms and in high risk population, also life style modification agenda by Govt .or non Govt. organization.
Molecular and Clinical Oncology, 2022
Colorectal cancer screening has long been recommended for middle age and older individuals. Recent evidence indicates increasing incidence and mortality among young adults. Therefore, the present study reexamined the current recommendations using an asymptomatic average-risk population screened by colonoscopy. A total of 716 participants of a wide age range were prospectively enrolled in an open-access endoscopic screening program based on self-referral. Comparisons between different age, gender and location groups, and receiver operating characteristic curves (ROC) curves for best age selection for detection of lesions were employed. Increased incidence of advanced lesions was observed in adults <50 years old. Although the polyp size was <1 cm in 85% of the cohort, a significant number of participants harbored advanced lesions. A disturbing incidence of lesions in women 30-49 years was located mainly in the left colon. One-third of the important pathology resides exclusively in the right colon. ROC curves demonstrated that with the current starting age of screening at 50 years, 92% of polyps and 95% of adenomas could be detected by colonoscopy, but a number of potential precancerous lesions will appear at an earlier age and therefore will be missed. The present study supported the notion that it is critical to reduce screening initiation below the currently accepted age of 50 years. Colonoscopy is a suitable method for addressing the increased prevalence of proximal lesions and the meticulous resection of smaller polyps.
Analysis of Colorectal Carcinoma in Patients Below 40 Years of Age with Suspected Clinical Features
2019
Objectives of the study: The main objective of the study is to analyse the colorectal carcinoma in patients below 40 years of age with suspected clinical features. Methodology of the study: This descriptive study was conducted in Health department Punjab during 2018 to 2019. Hospital records of patients under the age of 40 years who underwent CRC operations were included in this study. Specifically, the following documents where reviewed; admission notes, operative notes, discharge summaries, endoscopy records, and pathology reports. The main study variables included: demographics, presenting symptoms leading to diagnosis, family history of CRC, tumor location, type of surgical resection, stage and differentiation of disease, and post-operative complications. Results: One hundred eighty patients under 40 years of age (87 females, 93 males; range 17-49 years; mean 40.4 ± 3.2 years) underwent a CRC operation. When the total population of 180 patients under age 40 is considered, the distribution of CRC within age categories is as follows: under age 30 years, 8 patients (4%); age 30-39 years, 46 patients (26%); age 40-49 years, 126 (70%). Of note, 30% of the patients were younger than 40 years of age. One hundred and seventy patients (94%) reported symptoms upon presentation. Conclusion: It is concluded that the incidence of rectal and rectosigmoid cancer appears to be increasing in patients aged less than 40. Data confirms that in an ethnically diverse young population, CRC tends to be at an advanced stage, aggressive and frequently nonoperable at the time of diagnosis.
Colorectal neoplasia: Are young and female individuals remain at low risk for it?
Journal of Cancer Policy, 2018
Highlight points: *This is a large scale data of patients with colorectal adenoma. *There is no significant difference between age groups of patients for developing adenoma or malignancy. *We find that the young female are more prone for developing colorectal adenoma and malignancy. *We give a good estimation of colorectal neoplasia profile in this region.