Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas (original) (raw)

This study explores the genetic abnormalities present in well-differentiated liposarcomas (WDLPS), with a focus on the role of chromosome 12-derived sequences. A total of eight tumor samples were analyzed using comparative genomic hybridization (CGH) to identify regions of DNA amplification. The research reveals two distinct amplification units on chromosome 12, specifically in the q14-q15 and q21.3-q22 regions, which are consistently associated with WDLPS, suggesting the amplifications are linked to the presence of supernumerary ring and marker chromosomes.