Evaluation of fatty liver disease using ultrasound in a semi-urban population in Jos, North Central Nigeria (original) (raw)
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Estimation of Nonalcoholic Fatty Liver Disease in Patients with Normal BMI on Ultrasound
2021
Background: Non-Alcoholic fatty liver disease is common in adults and it is increasing in patients with normal BMI in Asian countries. Non-alcoholic fatty liver disease (NAFLD) occurs not only in obese individuals but also in non-obese ones. The association between NAFLD and metabolic events in a non-obese population is also evident.. Objective: To estimate nonalcoholic fatty liver disease in patients with normal BMI on ultrasound. Methodology: Analytical Cross-sectional prospective study in which 59 patients were enrolled in the research. All the patient's data had been composed from indoor of hospital, outdoor of hospital, DHA Medical Center, Lahore. After well-versed consent, data was composed through ultrasound machine. The data, such as patient characteristics, hypertension, impaired fasting glucose, were extracted from medical records, and statistical analysis was performed. Results: The present study is retrospective cross sectional observational study.60 patients (29males 49.2% 31 female 50.8%) were enrolled in this study. According to abdominal ultrasonography, 72.9% of patients with normal BMI were diagnosed to have Non-alcoholic fatty liver disease and identified to have fatty changes in the liver. In our study we estimated that nonalcoholic fatty liver disease was present in patients with normal body mass index by imaging the echotexture of liver on ultrasound. Having increased echogenicity, due to poor diet and other associated diseases such as high blood pressure, impaired fasting glucose and low HDL cholesterol patients were getting NAFLD.
Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk
The Kaohsiung Journal of Medical Sciences, 2012
Non-alcoholic fatty liver disease is associated with an increased risk of metabolic and cardiovascular diseases. Whether the severity of fatty liver on ultrasound correlates with metabolic or cardiovascular risk remains unclear. A total of 1000 people receiving health examinations were enrolled, and 126 were excluded due to the presence of HBsAg, anti-HCV, known hepatic disorders or alcohol use (>140 g/wk). Significant fatty liver consisted of moderate and severe fatty liver on ultrasound. The definition of central obesity was modified to a waist circumference of >90 cm in men and >80 cm in women. Framingham risk score was used to estimate the risk of cardiovascular disease. A total of 874 subjects (485 women and 388 men with a mean age of 52.07 AE 11.68 years) were included in the final analysis. By using logistic regression analyses stratified by gender, the odds ratio for the prevalence of diabetes mellitus, metabolic syndrome and risk of cardiovascular disease increased with increasing fatty liver status in both genders (p 0.001). The difference was not only present between individuals with fatty liver vs. non-fatty liver but also between the mild fatty liver and significant fatty liver groups (p < 0.05). In conclusion, the severity of fatty liver on ultrasound could be useful for the risk stratification of metabolic syndrome, diabetes mellitus and cardiovascular disease in clinical practice.
Evaluation of Fatty liver Infiltration Using Ultrasound among Sudanese Population
The main objective of this study is to evaluate fatty liver infiltration in Sudanese population using ultrasonography. This was a descriptive cross section study deals with assessment of patient affected with fatty liver infiltration using ultrasonography. The study conducted on141 patients confirmed fatty liver by routine transabdominal ultrasound carried out during the period from January to August 2016. Study was conducted in Khartoum state, Sudan, in different ultrasound departments of Khartoum hospitals and medical diagnostic centers. The analysis showed that 86 cases (61%) were female and 55 cases (39%) were male. The Prevalence was high among the age group (31-60) which represented 49 cases by (34, 8%). Most patients were overweight 124 cases (87.9%). Regarding patients' habit (alcoholic consumptions) and history of chronic disease (diabetic and hypertensive), most common affected disease was diabetic 47 patients (33.3%). Most patients were a symptomatic 76 cases (53.9%). Most patients affected by diffuse fatty infiltration and the most prominent. Liver size in most patients (75) by (53%) was normal, and (63) by (44.5%) had hepatomegaly. Most patients (66) by (46.8%) had a moderate degree of fatty infiltration. Also found there was strong positive relation between patient habit and history of disease and degree of fatty infiltration and liver size. No correlation found between patient's body mass index and degree of fatty infiltration. Study recommended that transabdominal ultrasonography should use as routine examination for high risk patient affected with fatty liver disease.
J Clin Med Kaz, 2020
Because of its complex pathogenesis and scarcity of approved therapies, non-alcoholic fatty liver disease is considered as one of the major challenge before mankind. Literature suggests that non-alcoholic fatty liver disease will replace Hepatitis C as a major form of chronic liver disease in adults and children over the next decade thus becoming the major cause of liver transplantation. Aim: To assess anthropometric, biochemical parameters and correlates of ultrasound-diagnosed non-alcoholic fatty liver disease patients. Material and methods: For this study a total of 182 subjects were selected from the department of Radiodiagnosis and Imaging, SKIMS medical college, Bemina, Srinagar, Jammu and Kashmir, India. Control group consisted of 91 age and sex matched subjects (mean age 51.69 ± 13.97 years) whereas case group consisted of 91 subjects (mean age 50.72 ± 12.13 years). Ultrasound under standardized conditions was performed in all subjects and the grading of non-alcoholic fatty liver disease was done in case group. Correlation of anthropometric and biochemical parameters with the non-alcoholic fatty liver disease was sought from the case group.
Background: The aim of this study was to evaluate the distribution of fatty liver-nonalcoholic (NAFL) and alcoholic (AFL)-and its association with metabolic syndrome and its components in a population sample from a Mediterranean area. Methods: A sample of 2974 subjects (1679 males, 1295 females, age range 30-89 years) was randomly drawn from the population of a town in southern Italy. The survey visit included a validated semiquantitative food frequency questionnaire, anthropometric measurements, a blood sample taken in the morning after overnight fasting, as well as abdominal ultrasound examination to evaluate liver fat with a standardized scoring system. The 2001 National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) definition of the metabolic syndrome was adopted. Results: In this Mediterranean population, where alcohol intake is mostly as wine with meals, NAFL is present in 36.8% of men and 25.7% of women and AFL in 13.8% of men and 5.5% of women. NAFL and AFL are associated with metabolic syndrome and its characteristics, body mass index (BMI), and visceral and subcutaneous fat (in AFL subjects, only in women) measured by ultrasound. Stratifying by BMI and controlling for confounders (age, height, smoking habit, and alcohol consumption), in overweight and obese subjects, liver and visceral fat are associated with the metabolic syndrome both in men and women and subcutaneous fat only in women. In normal weight subjects, only liver fat in men is associated with the metabolic syndrome. Conclusions: Fatty liver is highly prevalent in this Mediterranean population and is associated with metabolic syndrome in overweight and obese men and women as well as in men with normal BMI.
2016
Background/Aim. Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease of a broad histological spectrum, characterized by the accumulation of triglycerides in more than 5% of hepatocytes in the absence of consuming alcohol in quantities harmful to the liver. The aim of our study was to determine the importance of anthropometric and laboratory parameters as well as metabolic syndrome for the diagnosis of NAFLD and to estimate their influence on the degree of liver steatosis as evaluated by ultrasound. Methods. The study included 86 participants, 55 of whom had fatty liver diagnosed by ultrasound and they comprised the study group. The control group consisted of 31 subjects with no liver diseases. During the course of hospitalization at the Clinic of Gastroenterology and Hepatology, Clinical Centre Niš, the patients had their anamnesis taken, and anthropometric measurements as well as biochemical blood analyses and abdominal ultrasound were performed. Results. The patients with NAFLD had statistically higher values of body mass index (BMI), waist circumference (WC), systolic (SBP) and diastolic blood pressure (DBP), levels of alanine and aspartate aminotransferase (ALT, AST), gamma-glutamyl transpeptidase (GGT) (p < 0.001), low-density lipoprotein cholesterol (LDL), total bilirubin (TBIL) (p < 0.05), total cholesterol (p < 0.01), triglycerides (TGL), urates, C-reactive protein (CRP), ferritin, fibrinogenes, fasting blood glucose (FBG), insulin and Homeostasis Model Assessment (HOMA-IR) (p < 0.001) compared to the control group, whereas the levels of high-density lipo-protein cholesterol (HDL) were higher in the control than in the study group (p < 0.05). In the NAFLD group, there were statistically significantly more patients with hypertension (72.73% vs 12.90%, p < 0.001) and type 2 diabetes mellitus (DM) (47.27%). Metabolic syndrome was established in 48 (87.27%) patients of the study group. The equal number of patients, ie 16 (29.09%), had 3, 4 and 5 components of MS. In the NAFLD group there were 17 (30.91%) overweight (BMI from 25 kg/m 2 to 29.9 kg/m 2) and 38 (69.09%) obese patients (BMI ≥ 30.0 kg/m 2). The largest number of patients in the obesity group, 22 (40.00%) of them, had the first degree obesity (BMI from 30 kg/m 2 to 34.99 kg/m 2). The largest number of the NAFLD group patients, 23 (41.82%), had an ultrasound finding of grade 3 fatty liver, 20 (36.36%) patients had grade 2 and 12 (21.82%) grade 1 fatty liver. Kruskal-Wallis test and ANO-VA analysis showed statistically significant differences between groups with different US grade for insulin, LDLcholesterol, WC, BMI (p < 0.05), as well as HOMA-IR and body weight (BW) (p < 0.01). Metabolic syndrome was statistically more present in patients with US finding grades 2 and 3 (p < 0.01) in relation to US finding grade 1, as well as obesity, hypertension and DM type 2 (p < 0.05). Conclusion. The results of our study confirm that a high percentage of patients with high risk factors (DM, MS, dyslipidemia, hypertension) have NAFLD.
2018
Background: Non-alcoholic fatty liver disease (NAFLD) is a very common liver disease in the world, particularly in Western and developed countries. It is rapidly growing in the Asia-Pacific region. Objectives: This study was designed to determine the association between risk factors and non-alcoholic fatty liver disease grades among Malaysian adults. Patients and Methods: A cross-sectional observational study design was prospectively carried out in this study. Consecutive 628 respondents who attended for a medical checkup at urban health center had been recruited for the study. All respondents had physical examination, blood tests, clinical assessments and abdominal ultrasound. A structured self-administered questionnaire has been also used in this study in this survey. Results: From total of 628 " health screened " subjects, 235 subjects (37.4%) were diagnosed to have non-alcoholic fatty liver disease. Female gender and Chinese race were predominant in our study population. Of those with NAFLD, more than half subjects (63.4) had a moderate grade of non-alcoholic fatty liver disease. The mean age of the study population was 54.54 ±6.69 years. Differences of mean body mass index (BMI) and waist to hip ratio (WHR) were found to be significant among non-alcoholic fatty liver disease grades (P< 0.001). Similarly, mean triglycerides (TG) and high-densiy lipoprotein-cholesterol (HDL-C) levels had significant differences among non-alcoholic fatty liver disease grades (P< 0.001 and P= 0.016, respectively). Conclusion: non-alcoholic fatty liver disease is common among urban Malaysian adult population. Anthropometric measurements were a closely correlated with non-alcoholic fatty liver disease grades.
A Study of Non-Alcoholic Fatty Liver among Adults Using Ultrasonography
2019
Non-alcoholic fatty liver disease (NAFLD) is a common condition in Western countries. However, their metabolic characteristics are poorly known even though they could be important. Therefore, the objective of this study was to study the incidence & Prevalence of Nonalcoholic infiltration in Saudi Arabia (KSA) using ultrasound. The present study is a retrospective cross-sectional observational study.
Vojnosanitetski pregled, 2016
Background/Aim. Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease of a broad histological spectrum, characterized by the accumulation of triglycerides in more than 5% of hepatocytes in the absence of consuming alcohol in quantities harmful to the liver. The aim of our study was to determine the importance of anthropometric and laboratory parameters as well as metabolic syndrome for the diagnosis of NAFLD and to estimate their influence on the degree of liver steatosis as evaluated by ultrasound. Methods. The study included 86 participants, 55 of whom had fatty liver diagnosed by ultrasound and they comprised the study group. The control group consisted of 31 subjects with no liver diseases. During the course of hospitalization at the Clinic of Gastroenterology and Hepatology, Clinical Centre Niš, the patients had their anamnesis taken, and anthropometric measurements as well as biochemical blood analyses and abdominal ultrasound were performed. Results. The patients with NAFLD had statistically higher values of body mass index (BMI), waist circumference (WC), systolic (SBP) and diastolic blood pressure (DBP), levels of alanine and aspartate aminotransferase (ALT, AST), gamma-glutamyl transpeptidase (GGT) (p < 0.001), low-density lipoprotein cholesterol (LDL), total bilirubin (TBIL) (p < 0.05), total cholesterol (p < 0.01), triglycerides (TGL), urates, C-reactive protein (CRP), ferritin, fibrinogenes, fasting blood glucose (FBG), insulin and Homeostasis Model Assessment (HOMA-IR) (p < 0.001) compared to the control group, whereas the levels of high-density lipo-protein cholesterol (HDL) were higher in the control than in the study group (p < 0.05). In the NAFLD group, there were statistically significantly more patients with hypertension (72.73% vs 12.90%, p < 0.001) and type 2 diabetes mellitus (DM) (47.27%). Metabolic syndrome was established in 48 (87.27%) patients of the study group. The equal number of patients, ie 16 (29.09%), had 3, 4 and 5 components of MS. In the NAFLD group there were 17 (30.91%) overweight (BMI from 25 kg/m 2 to 29.9 kg/m 2) and 38 (69.09%) obese patients (BMI ≥ 30.0 kg/m 2). The largest number of patients in the obesity group, 22 (40.00%) of them, had the first degree obesity (BMI from 30 kg/m 2 to 34.99 kg/m 2). The largest number of the NAFLD group patients, 23 (41.82%), had an ultrasound finding of grade 3 fatty liver, 20 (36.36%) patients had grade 2 and 12 (21.82%) grade 1 fatty liver. Kruskal-Wallis test and ANO-VA analysis showed statistically significant differences between groups with different US grade for insulin, LDLcholesterol, WC, BMI (p < 0.05), as well as HOMA-IR and body weight (BW) (p < 0.01). Metabolic syndrome was statistically more present in patients with US finding grades 2 and 3 (p < 0.01) in relation to US finding grade 1, as well as obesity, hypertension and DM type 2 (p < 0.05). Conclusion. The results of our study confirm that a high percentage of patients with high risk factors (DM, MS, dyslipidemia, hypertension) have NAFLD.
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 2021
Non-alcoholic fatty liver disease (NAFLD) is considered as the most common liver disease in Western countries with still rising prevalence due to a lifestyle favoring the development of the metabolic syndrome. Aim: To investigate the prevalence of ultrasound-diagnosed NAFLD in patients with referral for sonographic examination of the abdomen, and to determine risk factors. Methods: After exclusion of patients with known liver disease or risk factors for secondary NAFLD, a total of 155 arbitrarily selected patients (mean age 53.6±17.4 years; 52.6% male) from the interdisciplinary ultrasound department of a German University Hospital were included in this prospective study. Each patient underwent a standardized ultrasound, anthropometric and biochemical examination. Results: The prevalence of ultrasound-diagnosed NAFLD was 40.0%. NAFLD-patients had significantly higher body mass index (BMI) and waist-to-hip ratio, higher rates of reported hypertension and diabetes mellitus, and lower HDL cholesterol serum levels.