Impact analysis of heart failure across European countries: an ESC‐HFA position paper (original) (raw)
Abstract
Heart failure (HF) is a long-term clinical syndrome, with increasing prevalence and considerable healthcare costs that are further expected to increase dramatically. Despite significant advances in therapy and prevention, mortality and morbidity remain high and quality of life poor. Epidemiological data, that is, prevalence, incidence, mortality, and morbidity, show geographical variations across the European countries, depending on differences in aetiology, clinical characteristics, and treatment. However, data on the prevalence of the disease are scarce, as are those on quality of life. For these reasons, the ESC-HFA has developed a position paper to comprehensively assess our understanding of the burden of HF in Europe, in order to guide future policies for this syndrome. This manuscript will discuss the available epidemiological data on HF prevalence, outcomes, and human costs-in terms of quality of life-in European countries.
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References (84)
- Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020; 22: 1342-1356.
- GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, preva- lence, and years lived with disability for 354 diseases and injuries for 195 coun- tries and territories, 1990-2017: a sys- ment Reviewers. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016; 18: 891-975.
- Hobbs FD, Kenkre JE, Roalfe AK, Davis RC, Hare R, Davies MK. Impact of heart failure and left ventricular systolic dysfunction on quality of life: a cross-sectional study comparing com- mon chronic cardiac and medical disor- ders and a representative adult popula- tion. Eur Heart J. 2002; 23: 1867-1876.
- Shafie AA, Tan YP, Ng CH. Systematic re- view of economic burden of heart fail- ure. Heart Fail Rev. 2018; 23: 131-145.
- Braunschweig F, Cowie MR, Auricchio A. What are the costs of heart failure? Europace. 2011; 13: ii13-ii17.
- Seferović PM, Vardas P, Jankowska EA, Maggioni AP, Timmis A, Milinković I, Polovina M, Gale CP, Lund LH, Lopatin Y, Lainscak M, Savarese G, Huculeci R, Kazakiewicz D, Coats AJS, National Heart Failure Societies of the ESC mem- ber countries. The Heart Failure Associa- tion Atlas: heart failure epidemiology and management statistics 2019. Eur J Heart Fail. 2021; 26.
- Bragazzi NL, Zhong W, Shu J, Abu Much A, Lotan D, Grupper A, Younis A, Dai H. Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017. Eur J Prev Cardiol. 2021: zwaa147.
- Ceia F, Fonseca C, Mota T, Morais H, Matias F, de Sousa A, Oliveira A, EPICA Investigators. Prevalence of chronic heart failure in Southwestern Europe: the EPICA study. Eur J Heart Fail. 2002; 4: 531-539.
- Ohlmeier C, Mikolajczyk R, Frick J, Prütz F, Haverkamp W, Garbe E. Inci- dence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons. Clin Res Cardiol. 2015; 104: 688-696.
- Zarrinkoub R, Wettermark B, Wändell P, Mejhert M, Szulkin R, Ljunggren G, Kahan T. The epidemiology of heart fail- ure, based on data for 2.1 million inhab- itants in Sweden. Eur J Heart Fail. 2013; 15: 995-1002.
- Buja A, Solinas G, Visca M, Federico B, Gini R, Baldo V, Francesconi P, Sartor G, Bellentani M, Damiani G. Prevalence of heart failure and adher- ence to process indicators: which socio-demographic determinants are in- volved? Int J Environ Res Public Health. 2016; 13: 238.
- Timmis A, Townsend N, Gale C, Grobbee R, Maniadakis N, Flather M, Wilkins E, Wright L, Vos R, Bax J, Blum M, Pinto F, Vardas P, ESC Scientific Document Group. European Society of Cardiology: cardiovascular disease statistics 2017. Eur Heart J. 2018; 39: 508-579.
- Levy D, Kenchaiah S, Larson MG, Benjamin EJ, Kupka MJ, Ho KK, Murabito JM, Vasan RS. Long-term trends in the incidence of and survival with heart failure. Engl J Med. 2002; 347: 1397-1402.
- Najafi F, Jamrozik K, Dobson AJ. Under- standing the 'epidemic of heart failure': a systematic review of trends in determi- nants of heart failure. Eur J Heart Fail. 2009; 11: 472-479.
- Gomez-Soto FM, Andrey JL, Garcia- Egido AA, Escobar MA, Romero SP, Garcia-Arjona R, Gutierrez J, Gomez F. Incidence and mortality of heart failure: a community-based study. Int J Cardiol. 2011; 151: 40-45.
- Sicras-Mainar A, Sicras-Navarro A, Palacios B, Varela L, Delgado JF. Epide- miology and treatment of heart failure in Spain: the HF-PATHWAYS study. Rev Esp Cardiol (Engl Ed). 2022; 75: 31-38.
- Fonseca C, Brás D, Araújo I, Ceia F. Heart failure in numbers: estimates for the 21st century in Portugal. Rev Port Cardiol (Engl Ed). 2018; 37: 97-104.
- Gouveia M, Ascenção R, Fiorentino F, Costa J, Caldeira D, Broeiro-Gonçalves P, Fonseca C, Borges M. The current and future burden of heart failure in Portugal. ESC Heart Fail. 2019; 6: 254-261.
- Dweck MR, Bularga A, Hahn RT, Bing R, Lee KK, Chapman AR, White A, Salvo GD, Sade LE, Pearce K, Newby DE, Popescu BA, Donal E, Cosyns B, Edvardsen T, Mills NL, Haugaa K. Global evaluation of echocardiography in pa- tients with COVID-19. Eur Heart J Cardiovasc Imaging. 2020; 21: 949-958.
- Sokolski M, Gajewski P, Zymliński R, Biegus J, Berg JMT, Bor W, Braunschweig F, Caldeira D, Cuculi F, D'Elia E, Edes IF, Garus M, Greenwood JP, Halfwerk FR, Hindricks G, Knuuti J, Kristensen SD, Landmesser U, Lund LH, Lyon A, Mebazaa A, Merkely B, Nawrocka-Millward S, Pinto FJ, Ruschitzka F, Semedo E, Senni M, Sepehri Shamloo A, Sorensen J, Stengaard C, Thiele H, Toggweiler S, Tukiendorf A, Verhorst PM, Wright DJ, Zamorano P, Zuber M, Narula J, Bax JJ, Ponikowski P. Impact of coronavirus disease 2019 (COVID-19) outbreak on acute admissions at the emergency and cardiology departments across Europe. Am J Med. 2021; 134: 482-489.
- Farmakis D, Mehra MR, Parissis J, Filippatos G. Heart failure in the course of a pandemic. Eur J Heart Fail. 2020; 2020: 1755-1758.
- Charman SJ, Velicki L, Okwose NC, Harwood A, McGregor G, Ristic A, Banerjee P, Seferovic PM, MacGowan GA, Jakovljevic DG. Insights into heart failure hospitalizations, management, and services during and beyond COVID-19. ESC Heart Fail. 2021; 8: 175-182.
- König S, Ueberham L, Pellissier V, Hohenstein S, Meier-Hellmann A, Thiele Impact analysis of HF across European countries
- ESC Heart Failure (2022) DOI: 10.1002/ehf2.14076
- H, Ahmadli V, Borger MA, Kuhlen R, Hindricks G, Bollmann A. Hospitaliza- tion deficit of in-and outpatient cases with cardiovascular diseases and utiliza- tion of cardiological interventions dur- ing the COVID-19 pandemic: insights from the German-wide helios hospital network. Clin Cardiol. 2021; 44: 392-400.
- König S, Hohenstein S, Meier-Hellmann A, Kuhlen R, Hindricks G, Bollmann A. In-hospital care in acute heart failure during the COVID-19 pandemic: insights from the German-wide Helios hospital network. Eur J Heart Fail. 2020; 22: 2190-2201.
- Taylor CJ, Roalfe AK, Iles R, Hobbs FD. Ten-year prognosis of heart failure in the community: follow-up data from the Echocardiographic Heart of England Screening (ECHOES) study. Eur J Heart Fail. 2012; 14: 176-184.
- Barasa A, Schaufelberger M, Lappas G, Swedberg K, Dellborg M, Rosengren A. Heart failure in young adults: 20-year trends in hospitalization, aetiology, and case fatality in Sweden. Eur Heart J. 2014; 35: 25-32.
- Salem K, El Khateeb O. Gender-adjusted and age-adjusted economic inpatient burden of congestive heart failure: cost and disability adjusted life-year analysis. ESC Heart Fail. 2017; 4: 259-265.
- Buddeke J, Valstar GB, van Dis I, Visseren FLJ, Rutten FH, den Ruijter HM, Vaartjes I, Bots ML, Queen of Hearts and RECONNECT investigators. Mortality after hospital admission for heart failure: improvement over time, equally strong in women as in men. BMC Public Health. 2020; 20: 36.
- Triposkiadis F, Xanthopoulos A, Butler J. Cardiovascular aging and heart failure: JACC review topic of the week. J Am Coll Cardiol. 2019; 74: 804-813.
- Koh AS, Tay WT, Teng THK, Vedin O, Benson L, Dahlstrom U, Savarese G, Lam CSP, Lund LH. A comprehensive population-based characterization of heart failure with mid-range ejection fraction. Eur J Heart Fail. 2017; 19: 1624-1634.
- Lenzen MJ, Scholte op Reimer WJ, Boersma E, Vantrimpont PJ, Follath F, Swedberg K, Cleland J, Komajda M. Dif- ferences between patients with a pre- served and a depressed left ventricular function: a report from the EuroHeart Failure Survey. Eur Heart J. 2004; 25: 1214-1220.
- Lund LH, Donal E, Oger E, Hage C, Persson H, Haugen-Löfman I, Ennezat PV, Sportouch-Dukhan C, Drouet E, Daubert JC, Linde C, KaRen Investiga- tors. Association between cardiovascular vs. non-cardiovascular co-morbidities and outcomes in heart failure with pre- served ejection fraction. Eur J Heart Fail. 2014; 16: 992-1001.
- Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola V, Hochadel M, Komajda M, Lassus J, Lopez-Sendon JL, Ponikowski P, Tavazzi L, EuroHeart Survey Investigators, Heart Failure Association, European So- ciety of Cardiology, EuroHeart Survey Investigators, Heart Failure Association, European Society of Cardiology. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart fail- ure patients: description of population. Eur Heart J. 2006; 27: 2725-2736.
- Crespo-Leiro MG, Anker SD, Maggioni AP, Coats AJ, Filippatos G, Ruschitzka F, Ferrari R, Piepoli MF, Delgado Jimenez JF, Metra M, Fonseca C, Hradec J, Amir O, Logeart D, Dahlström U, Merkely B, Drozdz J, Goncalvesova E, Hassanein M, Chioncel O, Lainscak M, Seferovic PM, Tousoulis D, Kavoliuniene A, Fruhwald F, Fazlibegovic E, Temizhan A, Gatzov P, Erglis A, Laroche C, Mebazaa A, Heart Failure Association (HFA) of the European Society of Cardi- ology (ESC). European Society of Cardi- ology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up out- comes and differences across regions. Eur J Heart Fail. 2016; 18: 613-625.
- Chioncel O, Lainscak M, Seferovic PM, Anker SD, Crespo-Leiro MG, Harjola VP, Parissis J, Laroche C, Piepoli MF, Fonseca C, Mebazaa A, Lund L, Ambrosio GA, Coats AJ, Ferrari R, Ruschitzka F, Maggioni AP, Filippatos G. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017; 19: 1574-1585.
- Boman K, Lindmark K, Stålhammar J, Olofsson M, Costa-Scharplatz M, Fonseca AF, Johansson S, Heller V, Törnblom M, Wikström G. Healthcare resource utilisation and costs associated with a heart failure diagnosis: a retro- spective, population-based cohort study in Sweden. BMJ Open. 2021; 11: e053806.
- Kamiya K, Sato Y, Takahashi T, Tsuchihashi-Makaya M, Kotooka N, Ikegame T, Takura T, Yamamoto T, Nagayama M, Goto Y, Makita S, Isobe M. Multidisciplinary cardiac rehabilita- tion and long-term prognosis in patients with heart failure. Circ Heart Fail. 2020; 13: e006798.
- Moita B, Marques AP, Camacho AM, Leão Neves P, Santana R. One-year rehospitalisations for congestive heart failure in Portuguese NHS hospitals: a multilevel approach on patterns of use and contributing factors. 2019; 9: e031346.
- Kurmani S, Squire I. Acute heart failure: definition, classification and epidemiol- ogy. Curr Heart Fail Rep. 2017; 14: 385-392.
- Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, Nodari S, Lam CSP, Sato N, Shah AN, Gheorghiade M. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014; 63: 1123-1133.
- Chioncel O, Mebazaa A, Harjola VP, Coats AJ, Piepoli MF, Crespo-Leiro MG, Laroche C, Seferovic PM, Anker SD, Ferrari R, Ruschitzka F, Lopez- Fernandez S, Miani D, Filippatos G, Maggioni AP, ESC Heart Failure Long-Term Registry Investigators. Clini- cal phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017; 19: 1242-1254.
- Chioncel O, Mebazaa A, Maggioni AP, Harjola VP, Rosano G, Laroche C, Piepoli MF, Crespo-Leiro MG, Lainscak M, Ponikowski P, Filippatos G, Ruschitzka F, Seferovic P, Coats AJS, Lund LH. Acute heart failure congestion and per- fusion status-impact of the clinical classification on in-hospital and long-term outcomes; insights from the ESC-EORP HFA Heart Failure Long-Term Registry. Eur J Heart Fail. 2019; 21: 1338-1352.
- Hollingworth W, Biswas M, Maishman RL, Dayer MJ, McDonagh T, Purdy S, Reeves BC, Rogers CA, Williams R, Pufulete M. The healthcare costs of heart failure during the last five years of life: a retrospective cohort study. Int J Cardiol. 2016; 224: 132-138.
- Jankowska EA, von Haehling S, Anker SD, Macdougall IC, Ponikowski P. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J. 2013; 34: 816-829.
- Rocha BML, Cunha GJL, Menezes Falcão LF. The burden of iron deficiency in heart failure: therapeutic approach. J Am Coll Cardiol. 2018; 71: 782-793.
- Ponikowski P, Kirwan BA, Anker SD, McDonagh T, Dorobantu M, Drozdz J, Fabien V, Filippatos G, Göhring UM, Keren A, Khintibidze I, Kragten H, Martinez FA, Metra M, Milicic D, Nicolau JC, Ohlsson M, Parkhomenko A, Pascual-Figal DA, Ruschitzka F, Sim D, Skouri H, van der Meer P, Lewis BS, Comin-Colet J, von Haehling S, Cohen- Solal A, Danchin N, Doehner W, Dargie HJ, Motro M, Butler J, Friede T, Jensen KH, Pocock S, Jankowska EA, AFFIRM-AHF investigators. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial. Lancet. 2020; 396: 1895-1904.
- Jankowska EA, Kirwan BA, Kosiborod M, Butler J, Anker SD, McDonagh T, Dorobantu M, Drozdz J, Filippatos G, Keren A, Khintibidze I, Kragten H, Mar- tinez FA, Metra M, Milicic D, Nicolau JC, Ohlsson M, Parkhomenko A, Pascual-Figal DA, Ruschitzka F, Sim D, Skouri H, van der Meer P, Lewis BS, Comin-Colet J, von Haehling S, Cohen- Solal A, Danchin N, Doehner W, Dargie HJ, Motro M, Friede T, Fabien V, Dorigotti F, Pocock S, Ponikowski P. The effect of intravenous ferric carboxymaltose on health-related qual- ity of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study. Eur Heart J. 2021: ehab234.
- McEwan P, Ponikowski P, Davis JA, Rosano G, Coats AJS, Dorigotti F, O'Sullivan D, Ramirez de Arellano A, Jankowska EA. Ferric carboxymaltose for the treatment of iron deficiency in heart failure: a multinational cost-effec- tiveness analysis utilising AFFIRM-AHF. Eur J Heart Fail. 2021; 30.
- Logeart D, Isnard R, Resche-Rigon M, Seronde MF, de Groote P, Jondeau G, Galinier M, Mulak G, Donal E, Delahaye F, Juilliere Y, Damy T, Jourdain P, Bauer F, Eicher JC, Neuder Y, Trochu JN, Heart Failure of the French Society of Cardiology. Current aspects of the spectrum of acute heart failure syndromes in a real-life setting: the OFICA study. Eur J Heart Fail. 2013; 15: 465-476.
- Miró Ò, García Sarasola A, Fuenzalida C, Calderón S, Jacob J, Aguirre A, Wu DM, Rizzi MA, Malchair P, Haro A, Herrera S, Gil V, Martín-Sánchez FJ, Llorens P, Herrero Puente P, Bueno H, Domínguez Rodríguez A, Müller CE, Mebazaa A, Chioncel O, Alquézar-Arbé A, ICA- SEMES Research Group. Departments involved during the first episode of acute heart failure and subsequent emergency department revisits and rehospitalisations: an outlook through the NOVICA cohort. Eur J Heart Fail. 2019; 21: 1231-1244.
- McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O'Meara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjöstrand M, Langkilde AM, DAPA-HF Trial Committees and In- vestigators. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019; 381: 1995-2008.
- Chioncel O, Parissis J, Mebazaa A, Thiele H, Desch S, Bauersachs J, Harjola VP, Antohi EL, Arrigo M, Gal TB, Celutkiene J, Collins SP, DeBacker D, Iliescu VA, Jankowska E, Jaarsma T, Keramida K, Lainscak M, Lund LH, Lyon AR, Masip J, Metra M, Miro O, Mortara A, Mueller C, Mullens W, Nikolaou M, Piepoli M, Price S, Rosano G, Vieillard-Baron A, Weinstein JM, Anker SD, Filippatos G, Ruschitzka F, Coats AJS, Seferovic P. Epidemiology, pathophysiology and contemporary management of cardiogenic shock-a position statement from the Heart Fail- ure Association of the European Soci- ety of Cardiology. Eur J Heart Fail. 2020; 22: 1315-1341.
- Johansson I, Dahlstrom U, Edner M, Nasman P, Ryden L, Norhammar A. Type 2 diabetes and heart failure: characteris- tics and prognosis in preserved, mid-range and reduced ventricular func- tion. Diab Vasc Dis Res. 2018; 15: 494-503.
- Savarese G, Settergren C, Schrage B, Thorvaldsen T, Löfman I, Sartipy U, Mellbin L, Meyers A, Farsani SF, Brueckmann M, Brodovicz KG, Vedin O, Asselbergs FW, Dahlström U, Cosentino F, Lund LH. Comorbidities and cause-specific outcomes in heart failure across the ejection fraction spectrum: a blueprint for clinical trial design. Int J Cardiol. 2020; 313: 76-82.
- Norhammar A, Bodegård J, Nyström T, Eriksson JW, Thuresson M, Nathanson D. Incidence, prevalence and mortality of type 2 diabetes requiring glucose-lowering treatment, and associ- ated risks of cardiovascular complica- tions: a nationwide study in Sweden, 2006-2013. Diabetologia. 2016; 59: 1692-1701.
- Rawshani A, Rawshani A, Franzén S, Sattar N, Eliasson B, Svensson AM, Zethelius B, Miftaraj M, McGuire DK, Rosengren A, Gudbjörnsdottir S. Risk factors, mortality, and cardiovascular outcomes in patients with type 2 diabe- tes. N Engl J Med. 2018; 379: 633-644.
- Ritsinger V, Nystrom T, Saleh N, Lagerqvist B, Norhammar A. Heart fail- ure is a common complication after acute myocardial infarction in patients with diabetes: a nationwide study in the SWEDEHEART registry. Eur J Prev Cardiol. 2020; 27: 1890-1901.
- Birkeland K, Bodegard J, Eriksson JW, Norhammar A, Haller H, Linssen GCM, Banerjee A, Marcus Thuresson M, Okami S, Garal-Pantaler E, Overbeek J, Mamza JB, Zhang R, Yajima T, Komuro I, Kadowaki T. Heart failure and chronic kidney disease manifestation and mor- tality risk associations in type 2 diabe- tes: a large multinational cohort study. Diabetes Obes Metab. 2020; 22: 1607-1618.
- Lewis EF, Lamas GA, O'Meara E, Granger CB, Dunlap ME, McKelvie RS, Probstfield JL, Young JB, Michelson EL, Halling K, Carlsson J, Olofsson B, McMurray JJV, Yusuf S, Swedberg K, Pfeffer MA, CHARM Investigators. Char- acterization of health-related quality of life in heart failure patients with pre- served versus low ejection fraction in CHARM. Eur J Heart Fail. 2007; 9: 83-91.
- Jaarsma T, Johansson P, Agren S, Strömberg A. Quality of life and symp- toms of depression in advanced heart failure patients and their partners. Curr Opin Support Palliat Care. 2010; 4: 233-237.
- Hoekstra T, Lesman-Leegte I, van Veldhuisen DJ, Sanderman R, Jaarsma T. Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction. Eur J Heart Fail. 2011; 13: 1013-1018.
- Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G. How to diag- nose heart failure with preserved ejec- tion fraction: the HFA-PEFF diagnostic algorithm: a consensus recommenda- tion from the Heart Failure Association (HFA) of the European Society of Cardi- ology (ESC). Eur J Heart Fail. 2020; 22: 391-412.
- Iqbal J, Francis L, Reid J, Murray S, Denvir M. Quality of life in patients with chronic heart failure and their carers: a 3-year follow-up study assessing hospi- talization and mortality. Eur J Heart Fail. 2010; 12: 1002-1008.
- Rasmussen AA, Johnsen SP, Berg SK, Rasmussen TB, Borregaard B, Thrysoee L, Thorup CB, Mols RE, Wiggers H, Larsen SH. Predictors of patient-reported outcomes at discharge in patients with heart failure. Eur J Cardiovasc Nurs. 2020; 19: 748-756.
- Jaarsma T, Hill L, Bayes-Genis A, La Rocca HB, Castiello T, Čelutkienė J, Marques-Sule E, Plymen CM, Piper SE, Riegel B, Rutten FH, Ben Gal T, Bauersachs J, Coats AJS, Chioncel O, Lopatin Y, Lund LH, Lainscak M, Moura B, Mullens W, Piepoli MF, Rosano G, Seferovic P, Strömberg A. Self-care of heart failure patients: practical manage- ment recommendations from the Heart Failure Association of the European So- ciety of Cardiology. Eur J Heart Fail. 2021; 23: 157-174.
- Komajda M, Cowie MR, Tavazzi L, Ponikowski P, Anker SD, Filippatos GS. Physicians' guideline adherence is asso- ciated with better prognosis in outpa- tients with heart failure with reduced ejection fraction: the QUALIFY interna- tional registry. Eur J Heart Fail. 2017; 19: 1414-1423.
- Van Spall HGC, Rahman T, Mytton O, Ramasundarahettige C, Ibrahim Q, Kabali C, Coppens M, Brian Haynes R, Connolly S. Comparative effectiveness of transitional care services in patients discharged from the hospital with heart failure: a systematic review and network meta-analysis. Eur J Heart Fail. 2017; 19: 1427-1443.
- Vitale C, Spoletini I, Rosano GM. Frailty in heart failure: implications for man- agement. Card Fail Rev. 2018; 4: 104-106.
- Butler J, Anker SD, Filippatos G, Khan MS, Ferreira JP, Pocock SJ, Giannetti N, Januzzi JL, Piña IL, Lam CSP, Ponikowski P, Sattar N, Verma S, Brueckmann M, Jamal W, Vedin O, Impact analysis of HF across European countries 11 ESC Heart Failure (2022) DOI: 10.1002/ehf2.14076
- Peil B, Zeller C, Zannad F, Packer M, EMPEROR-Reduced Trial Committees and Investigators. Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial. Eur Heart J. 2021; 42: 1203-1212.
- McMurray J, Parker M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, PARADIGM-HF Investiga- tors and Committees. Angiotensin- neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014; 371: 993-1004.
- Nagy KV, Merkely B, Rosero S, Geller L, Kosztin A, McNitt S, Polonsky B, Goldenberg I, Zareba W, Kutyifa V. Quality of life predicting long-term out- comes in cardiac resynchronization ther- apy patients. Europace. 2019; 21: 1865-1875.
- Crespo-Leiro MG, Metra M, Lund LH, Milicic D, Costanzo MR, Filippatos G, Gustafsson F, Tsui S, Barge-Caballero E, De Jonge N, Frigerio M, Hamdan R, Hasin T, Hülsmann M, Nalbantgil S, Potena L, Bauersachs J, Gkouziouta A, Ruhparwar A, Ristic AD, Straburzynska-Migaj E, McDonagh T, Seferovic P, Ruschitzka F. Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018; 20: 1505-1535.
- Spoletini I, Ferrari R, Rosano GMC. Liv- ing with stable angina: patients' path- way and needs in angina. J Cardiovasc Med (Hagerstown). 2020; 21: 377-382.
- Van Deursen VM, Urso R, Laroche C, Damman K, Dahlstom U, Tavazzi L, Maggioni AP, Voors AA. Comorbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey. Eur J Heart Fail. 2014; 16: 103-111.
- Greene SJ, Butler J, Spertus JA, Hellkamp AS, Vaduganathan M, DeVore AD, Albert NM, Duffy CI, Patterson JH, Thomas L, Williams FB, Hernandez AF, Fonarow GC. Comparison of New York Heart Association class and patient-reported outcomes for heart fail- ure with reduced ejection fraction. JAMA Cardiol. 2021; 6: 522-531.
- Ruppar TM, Cooper PS, Mehr DR, Delgado JM, Dunbar-Jacob JM. Medica- tion adherence interventions improve heart failure mortality and readmission rates: systematic review and meta-analysis of controlled trials. J Am Heart Assoc. 2016; 5: e002606.
- Heidenreich PA, Hernandez AF, Yancy CW, Liang L, Peterson ED, Fonarow GC. Get With The Guidelines program participation, process of care, and out- come for Medicare patients hospitalized with heart failure. Circ Cardiovasc Qual Outcomes. 2012; 5: 37-43.
- Burns DJP, Arora J, Okunade O, Beltrame JF, Bernardez-Pereira S, Crespo-Leiro MG, Filippatos GS, Hardman S, Hoes AW, Hutchison S, Jessup M, Kinsella T, Knapton M, Lam CSP, Masoudi FA, McIntyre H, Mindham R, Morgan L, Otterspoor L, Parker V, Persson HE, Pinnock C, Reid CM, Riley J, Stevenson LW, McDonagh TA. International Consortium for Health Outcomes Measurement (ICHOM): standardized patient-centered outcomes measurement set for heart failure pa- tients. JACC Heart Fail. 2020; 8: 212-222.
- Lund LH, Carrero JJ, Farahmand B, Henriksson KM, Jonsson Å, Jernberg T, Dahlström U. Association between en- rolment in a heart failure quality regis- try and subsequent mortality-a nation- wide cohort study. Eur J Heart Fail. 2017; 19: 1107-1116.
- Smeets M, Henrard S, Aertgeerts B, Cools F, Janssens S, Vaes B. Methods to identify heart failure patients in general practice and their impact on patient characteristics: a systematic review. Int J Cardiol. 2018; 257: 199-206.
- Guha K, McDonagh T. Heart failure epi- demiology: European perspective. Curr Cardiol Rev. 2013; 9: 123-127.