Genotypic properties of collection plague microbes strains from the natural plague foci of Kazakhstan (original) (raw)
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Plague, infamous due to three devastating pandemics, remains one of the most dangerous human diseases. Its causative agent, the microbe Yersinia pestis, is a priority in the arsenal of possible biological weapons, which requires increased attention to the development of a system of biological (bacteriological) security. A deep knowledge of the natural processes that facilitate the development of the causative agent of plague may be useful for this. There are currently two alternative approaches to determining the origin of Y. pestis – molecular genetics (MG) and ecological. MG-data has led to the innovative idea of the saltation conversion of the psichrophilic saprozoonotic microbe Yersinia pseudotuberculosis O:1b into a population of the pathogenic plague microbe Y. pestis, by horizontal transfer of two specific plasmids pFra and pPst from the external environment, or from other bacteria and inactivated/deletions of genes that have lost their functions in a new habitat, probably in...
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Российский научно-исследовательский противочумный институт «Микроб», Саратов 2 центр гигиены и эпидемиологии в Саратовской области, Саратов, Россия epidemic actiVitY of modern anthropourgic plague foci and factors determining this actiVitY (BY the eXample of Vietnam) sludsky a. a. 1 , Kuznetsov a. a. 1 , matrosov a. n. 1 , Boiko a. V. 1 , Kouklev e. V. 1 , tarasov m. a. 2 1 russian research anti-plague institute «microbe», saratov 2 center of hygiene and epidemiology in the saratov region, saratov, russia
Problems of Particularly Dangerous Infections, 2021
The aim of the study was to clarify the boundaries of the Central Asian natural plague focus of Kazakhstan and the modern boundaries of the areal of the great gerbil (Rhombomys opimus) in order to improve epizootiological monitoring and increase the effectiveness of preventive (anti-epidemic) measures.Materials and methods. Data from the epizootiological monitoring of the great gerbil populations in 14 autonomous foci of the Central Asian desert natural plague focus in the Republic of Kazakhstan between 2010 and 2020 were used for the analysis. An epizootiologic survey of an area of 875350 km2 was carried out. When processing the data, epidemiological, epizootiological, statistical research methods, as well as GIS technologies were used.Results and discussion. An increase in the total area of the Central Asian desert natural plague focus of the Republic of Kazakhstan by 79710 km2 (9.98 %) has been established for the period of 1990–2020. It is noted that the change in the area of pl...
Acta biomedica scientifica, 2017
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Acta Biomedica Scientifica, 2019
Revealed by morphological characters, physiological status, and genetic diversity of populations of the main plague host Rhombomys opimus Licht., 1823 in Central Asia desert natural focus is described.Differences in the skull parameters of R. opimus from different populations were revealed. It’s shown that gerbils from Moyunkum are separate autonomous populations group. Samples from Moyunkum and Mangyshlak differed from other samples. In Balkhash-Alakol depression found two regional complexes: Pre-Balkhash and Dzungarian.Study results of free amino acids level in R. opimus blood serum obtained by gas-liquid chromatography of blood sera from animals captured in different zones of Central Asian focus gave statistically significant differences. To determine genetic variability in ecological and geographical isolation of R. opimus populations the DNA was genotyped.DNA samples analysis combined the studied gerbil from the desert focus into four clusters with eighteen haplotypes. R. opimu...
Problems of Particularly Dangerous Infections
The aim of the study was to improve epizootiological monitoring and increase the effectiveness of preventive (anti-epidemic) measures for camel plague control in Kazakhstan.Materials and methods. We used the data on epizootiological and epidemiological monitoring in natural plague foci of Kazakhstan, long-term measurements and indicators for the period of 2000–2020 of the anti-plague and veterinary services of the Republic for the analysis. To process the evidence, epidemiological, epizootiological, microbiological, and statistical research methods, as well as GIS technology were applied.Results and discussion. The number of camels has increased by 2.2 times in Kazakhstan over the past 20 years. Where there were 98.2 thousand heads in 2000, it amounted to 216.4 thousand heads in 2020. Over the past 10 years, 152 camels died of unknown causes in the focal area of the country, but laboratory tests for plague turned out negative. According to the hazard criteria, the territory of the ...