Locus control region-A gamma transgenic mice: a new model for studying the induction of fetal hemoglobin in the adult (original) (raw)

Abstract

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This study introduces a new model for investigating the induction of fetal hemoglobin (HbF) in adults using transgenic mice carrying human fetal (y) globin genes. The research reveals that traditional pharmacologic agents previously used in human studies do not activate the human y-globin gene in certain mouse lines, suggesting the involvement of the locus control region (LCR) linked to the Ay globin gene as a viable option for HbF induction. The findings underscore the potential use of LCR-Ay transgenic mice in further understanding the mechanisms behind HbF induction in adult models.

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