Nanoparticles: a New Approach to the Diagnosis and Treatment of Cerebral Glial Tumours (original) (raw)
Related papers
A New View on the Application of Gold Nanoparticles in Cancer Therapy
arXiv (Cornell University), 2023
In biomedical research and the practice of cancer therapy, gold nanoparticles have been used to visualize malignant tumors, as the heated bodies for hyperthermia of cancer cells, as drug carriers to deliver drugs to a cancer cell, but, to the best of our knowledge, they have not yet been used consciously as the sources of terahertz (THz) radiation delivered to a cancer cell that contributes to the inhibition of cell activity. It is predicted here that gold nanoparticles ≤ 8 nm in size are sources of spontaneous THz radiation, and the possibility of their application in oncology is due to the known effects of THz radiation on the cells of living organisms. There are indications that nanoparticles with a size comparable to the width of the major groove of the DNA molecule will be the most effective. Another effect that has not yet been taken into account in biomedical studies using gold nanoparticles is that of local electric fields due to the contact potential difference above edges and vertices of gold nanoclusters. The prerequisites and possibilities for searching for the manifestations of these two effects when gold nanoparticles are introduced into living cells of organisms are considered.
Medical Visualization, 2021
Purpose of study. The possibility of simultaneous and combined use of magnetic resonance imaging (MRI) with paramagnetic contrast enhancement (CE-MRI) and single-photon emission computed tomography (SPECT) with 99mTc-MIBI in assessing the prognosis in patients with glial brain tumors after complex chemo – and radiotherapy treatment was studied.Material and methods. Contrast-enhanced MRI of the brain and SPECT with 99mTc-Technetril were performed in 19 patients who were observed after complex chemoradiotherapy of brain tumors (gliomas of grade 3 and 4). The treatment included remote gamma irradiation and chemotherapy with temozolomide. The radiation dose was 60 Gy (30 fractions of 2 Gy × 1 once a day). The drug Temodal was prescribed in a single dose of 75 mg/sq. m. (120–140 mg) an hour before gamma therapy for up to 40 days (in a total dose of 5000–5900 mg) and in the post – radiation period according to the scheme – 6 courses of the drug for 5 days every 23 days in a single dose of...
Targeting Tumor Microenvironment Through Nanotheranostics
Nanomedicine for Cancer Diagnosis and Therapy, 2021
Качество аудита: сущность и оценка © 2009 М.А. Азарская кандидат экономических наук, доцент Марийский государственный технический университет В статье рассматривается системный подход к пониманию качества аудита. Анализируются характеристики качества и методы их оценки.
Subsequent gliomas in survivors of paediatric neoplasms
Pediatric Hematology/Oncology and Immunopathology, 2018
научно-практический центр специализированных видов медицинской помощи (онкологический)» 3 ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва 4 ФГаУ «Национальный медицинский исследовательский центр нейрохирургии имени академика Н.
CLINICAL AND EXPERIMENTAL MORPHOLOGY, 2021
Introduction. Doxorubicin (Dox) in the composition of poly(lactic-co-glycolic acid, 50:50) (PLGA) – nanoparticles has high antitumor efficacy in rats with glioblastoma 101.8. However, the toxic effect of Dox-PLGA is not well understood. The aim of the study was morphological and biochemical evaluation of the hepatotoxic and cardiotoxic effects of doxorubicin and Dox-PLGA in the glioblastoma 101.8 treat-ment in Wistar rats. Materials and methods. The study was performed on 24 male Wistar rats with glioblastoma: no treatment (n=7), treated with doxorubicin (n=9) or Dox-PLGA (n=8) intravenously at a dose of 1.5 mg/kg on days 2, 5 and 8 after tumor implantation. On the 14th day of the experiment, morphological changes in the myocardium and liver were examined. Hematological and biochemical blood tests were performed. Results.When treating rats with experimental glioblastoma 101.8, Dox-PLGA in comparison with doxorubicin has less pronounced cardiotoxic and hepatotoxic effects according t...
Ukrainian Neurosurgical Journal, 2021
Objective: to study the effect of antiangiogenic therapy on the quality of life and the level of headache in patients with recurrent glioblastoma who underwent radiosurgical treatment. Materials and methods. A prospective randomized single-center study carried out at the Romodanov Neurosurgery Institute of National Academy of Medical Sciences of Ukraine in 2019-2020 involving 45 patients with GB with clinical and radiological signs of disease progression and local tumor recurrence. In this regard, patients underwent radiosurgical treatment. In the main group (BEV+) 21 patients after stereotactic radiosurgery (SRS) underwent antiangiogenic therapy with Bevacizumab (BEV). In the control group (BEV–), 24 patients did not receive antiangiogenic therapy after SRS. SRS with the use of a linear accelerator «Trilogy» (6 MeV) using intensity-modulated radiotherapy (IMRT). BEV was administered intravenously, once every 3 weeks at a dose of 10 mg / kg body weight. Antiangiogenic therapy was pe...
НАНОМЕДИЦИНА, 2018
Использование достижений наномедицины и материаловедения в диагностике заболеваний является перспективным направлением научных исследований. Спектроскопия гигантского комбинационного рассеяния (ГКР) — инновационный метод анализа, связанный с применением наноматериалов на основе благородных металлов для неинвазивного исследования клеток, клеточных органелл, белковых молекул. В работе обобщены литературные данные по методам ранней клинической диагностики ряда нейродегенеративных и нейроэндокринных заболеваний. Обсуждены особенности, достоинства и ограничения различных методов диагностики по низкомолекулярным и высокомолекулярным маркерам указанных заболеваний. Продемонстрированы перспективы применения оптических методов для экспресс-диагностики нарушений нейромедиаторного обмена. Особое внимание уделено новым подходам при создании универсальных оптических индикаторных систем, расширяющих аналитические возможности спектроскопии ГКР, обладающей уникально высокой чувствительностью, селек...
Vestnik Rentgenologii i Radiologii
Цель исследования-разработка дифференциально-диагностических критериев рецидива глиом после комплексного лечения с использованием динамической контрастной магнитнорезонансной ангиографии (ДК-МРА) и Т2*-перфузионной магнитно-резонансной томографии (МРТ). Материал и методы. В ретроспективное исследование включены 16 мужчин и 7 женщин (средний возраст 34,6 ± 15,4 года), прошедших мультипараметрическую МРТ головного мозга для исключения рецидива опухолевого заболевания после комбинированного лечения. В состав исследования входили следующие протоколы: 1) статическая контрастная МРТ, включая Т2-и Т1-взвешенные изображения (ВИ), а также постконтрастные Т1-ВИ на 5-8-й минуте после ДК-МРА; 2) ДК-МРА в дозе 0,2 ммоль/кг; 3) на фоне предконтрастирования Т2*-перфузионная МРТ в дозе 0,1 ммоль/кг. Морфологическая диагностика была проведена во всех случаях. Гемодинамика опухолей оценивалась на ДК-МРА с использованием коэффициентов контрастности в каждую фазу сканирования, а также коэффициентов усиления и венозно-артериального Objective: to elaborate differential diagnostic criteria for recurrent gliomas after combination treatment, by using dynamic contrast-enhanced magnetic resonance angiography (DCE-MRA) and T2*-weighted perfusion magnetic resonance imaging (MRI). Material and methods. The retrospective study enrolled 16 men and 7 women (mean age 34.6±15.4 years) who had undergone multiparametric magnetic resonance imaging of the brain to prevent cancer recurrence after combination treatment. The study used the following protocols: 1) static contrast-enhanced MRI, including T2-and T1-weighted MRI, and post-contrastenhanced T1-weighted images at 5-8 minutes after DCE-MPA); 2) DCE-MPA at a dose of 0.2 mmol/kg; 3) in the presence of precontrast-enhanced T2*-weighted perfusion MRI at a dose of 0.1 mmol/kg. A morphological diagnosis was done in all cases. Tumor hemodynamics was evaluated by DCE-MRA using contrast ratios (CR or CBR) in each scanning phase, as well as contrastenhancement ratios (ER or CER) and a venous-arterial ratio in the first venous phase (VAR1). Relative Cerebral Blood Volumes (rCBV) were estimated on the contrast-enhanced T1-weighted
The physical properties of lactose coated zinc selenide quantum dots as potential biomarkers obtained by a low-temperature colloidal synthesis in an aqueous medium were analyzed. The presence on the surface of the obtained nanoparticles adsorbed lactose promotes their use for the visualization of cancer cells. The presence of broadening the band gap of quantum dots compared to the band gap of the semiconductor volume was shown. It was found that increasing the lactose content leads to a reduction in the size of the nanoparticles, but too much of the coating agent can interfere with their education.