Formulatio a D Evaluatio of Mouth Dissolvi G Tablets of O Da Setro Hydrochloride (original) (raw)
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International Journal of Pharmacy and Pharmaceutical Sciences, 2019
Objective: The aim of the present study was to prepare the ondansetron hydrochloride Mouth Dissolving Tablets (MDTs) followed by its comparison with ethical and non-ethical (generic) marketed tablets. Methods: Prior to the formulation, drug excipient compatibility study was carried out by FTIR spectroscopy. The λmax was determined by UV spectroscopy. The ondansetron hydrochloride MDTs were prepared by direct compression method using Sodium Starch Glycolate (SSG) as super disintegrant and camphor as a sublimating agent. Then the prepared MDTs were subjected to evaluation of post compression parameters such as thickness and diameter, weight variation, wetting time, hardness, friability, disintegration and dissolution. The results obtained were compared with that of ethical and non-ethical marketed ondansetron hydrochloride 4 mg tablets. Results: The λmax was found at 310 nm. FTIR study revealed that excipients used in the prepared formulations are compatible with the drug. The thickne...
International Journal of Pharmaceutical Sciences and Drug Research, 2017
Mouth dissolving tablet is an innovative solid unit dosage form that overcome the problem of swallowing and provide rapid disintegration and dissolution to release the drug as soon as they come in contact with saliva, hence provide quick onset action. The aim of this study was to formulate and evaluate mouth dissolving tablets of Ondansetron hydrochloride using natural super disintegrating agent. Ondansetron hydrochloride is a serotonin receptor (5-HT3) antagonist used to treat nausea and vomiting arises during chemotherapy and radiation therapy. Mouth dissolving tablets were prepared by direct compression method using natural super disintegrating agent (Plantago ovata mucilage). Prepared tablet were evaluated for Hardness, weight variation, friability, thickness, wetting time, dispersion time, water absorption ratio, disintegration and dissolution study. According to results of optimized batches it has been concluded that Formulation batch F6 was an ideal batch which contain 12% w/...
The Journal of Pharmaceutical Sciences and Medicinal Research, 2021
In the present time, a mouth dissolving tablets become popular over conventional oral solid dosage form as it overcome common problem associated with conventional oral tablet dosage form such as issue in swallowing tablets in paediatric as well as geriatric population as well as avoid first pass metabolism and provide quick onset of action as it starts to absorb directly from oral cavity. Ondansetron HCl is used to prevent nausea and vomiting. In case of vomiting as well as in nausea, drug must require to act quickly to treat therapeutic condition of patient in need thereof. Therefore, combining Mouth dissolving technology with Ondansetron HCl as active pharmaceutical ingredient could be potential strategy to provide quick onset of action without swallowing entire tablet. Therefore, aim of the present research work is to fabricate mouth dissolving tablets of Ondansetron HCl using different concentration, i.e. 3%, 5% and 9%w/w, of different water insoluble super-disintegrants, namely...
Mouth Disintegrating Tablets of Taste-Masked Ondansetron HCl
Ondansetron HCl is used in the management of nausea and vomiting induced by cytotoxic chemotherapy and radio-therapy and is bitter drug. The purpose of research work was focused on taste masking of the Ondansetron HCl and further development of the drug in mouth disintegrating tablets. Ion exchange resins, Indion 204 and Indion 234 were used with a view to mask the taste of the drug. Tablet formulations were prepared using wet granulation and direct compression tech-niques. All formulations were subjected to post compression parameters like uniformity of thickness, hardness, friability test, weight variation and drug content uniformity, all these parameters were within pharmacopoeial limits. Formulations FW 6 and FD 2 showed 102.34 ± 1.34 and 101.94 ± 1.54 % of drug release after 15 min, respectively. Volunteer did not feel bitter taste with these formulations (FW 6 and FD 2). These selected formulations were subjected for stability studies and were found to be stable for 3 month at...
Taste Masking and Formulation of Ondansetron Hydrochloride Mouth Dissolving Tablets
International Journal of Drug Delivery Technology, 2015
This study was done to mask the bitter taste of ondansetron HCl using complexing agent, a polacrilex resin: Tulsion 335 and subsequently forming mouth dissolving tablet using superdisintegrants: Croscarmellose sodium and sodium starch glycollate. A preliminary screening was done. Batch process, a most preferential method for drug loading with ion exchange resins was selected. The process was optimized for drug: resin ratio to get maximum drug loading. A ratio of drug: resin at 1:3 was selected. Taste evaluation was carried out by selecting volunteers. Drug resin complex (DRC) was evaluated for drug release. The resultant DRC was formulated by direct compression into mouth dissolving tablet using microcrystalline cellulose PH 102, as diluent and croscarmalose sodium and sodium starch glycolate as superdisintegrants and aspartame was used as sweetening agent to enhance palatability. Thirteen formulations were developed by using superdisintegrants: croscarmellose sodium and sodium star...
The demand for fast dissolving tablets of OndansetronHCl has been growing during the last decade specially for the geriatric and pediatric patients. OndansetronHCl is a recognized as antiemetic drug, so development of an FDT OndansetronHCl and to evaluate the effect of various concentrations of superdisintegrant and binder on its disintegration time and release profile was the prime objective of this research work. Methods: Tablets were prepared by high pressure homogenization followed by direct compression. 22 factorial design was applied in which concentration of superdisintegrant and binder were taken as independentvariables and disintegration time and percentage release were taken as dependent variables. The prepared tablets wereevaluated for weight variation, hardness, friability, disintegration time, content uniformity, and % drug release. Direct compression process was selected for this formulation of ODT tablets, because porous nature is more in direct compression blend than...
Asian Journal of Applied Science and Technology (AJAST), 2021
Objective: The aim of this study was to develop a simple method for manufacturing oral dispersible tablets of ondansetron hydrochloride using direct compression method and to study the effect of different types and concentration of natural disintegrant (Isabgol mucilage, fenugreek mucilage and dehydrated banana powder) on the disintegrating characteristics of the tablets. Method: Disintegrants extracted from Isabgol, fenugreek and banana powder were used in formulation of tablet using placket burman design in minitab. Then 13 different formulations (F1- F13) were prepared varying the concentration of selected natural disintegrant (Isabgol mucilage extract 6-15%). Formulated tablets were investigated for weight variation, hardness, thickness, disintegration, drug content, friability. Result: The result obtained from disintegration study of tablets prepared using natural disintegrant obtained from isabgol mucilage indicates that the Isabgol with concentration 11.47% shows the disintegration time of 27 seconds. Conclusion: Orodispersible tablet of ondansetron hydrochloride was found to be effective with natural disintegrant obtained from isabgol mucilage
Development and Evaluation of Ondansetron Orally Disintegrating Tablets
British Journal of Pharmacy, 2018
Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix by superdisintegrant and other is effect of sweetener on the formulation. Direct compression method was employed for making orally disintegrating tablets. The formulated orally disintegrating tablets have rapid disintegration property for better patient compliance. Formulated tablets were evaluated for physical parameters along with wetting time, disintegration time, drug content and "in vitro" dissolution. In first approach it was found that batch F7 containing Crospovidone (Polyplasdone XL 10) 10 mg showed minimum disintegration time (i.e. approx. 7.00 seconds) with maximum drug release. Wetting time for batch F7 was found to beminimum (i.e. 12 seconds). In second approach of selection of sweetener batch F 10 containing Sodium saccharin was found better in terms of Impurity study (Relative Substances study).Impurity was found within the specified limit compared to other two sweeteners. Stability study was carried out on optimized formulation. Overall batch containing 10 mg Crospovidone (Polyplasdone XL 10) along with Sodium Saccharin was foundstable both physically and chemically.
Indian Journal of Pharmaceutical Education and Research, 2014
The formulation of sublingual tablets of Ondansetron HCl was carried out by using direct compression technique and evaluation tests were carried out as per pharmacopoeial specifications. Poor compressibility problem of Mannitol was overcome by coprocessing it with maltose and corn starch in varying ratios. The results of evaluation tests indicate that the ratio of Mannitol: Maltose: Corn starch: 19:2:1 gave better tableting performance with respect to precompression & postcompression parameters. It was also observed that increase in maltose content, increased the hardness but negatively affects disintegration and drug release and vice versa. Furthermore the study on effect of superdisintgrants shows that Crospovidone gives faster disintegration and satisfactory drug release in concentration of 4% compared to that of Sodium starch glycolate & Croscarmelose sodium. Formulation using a bioadhesive polymer PVP K 30 in ratio of 0.5% showed uniform release of drug over a period of 20 minutes with complete solubilization of tablet compared to that of gelatin and carbopol 934. On numerical optimization of prepared formulations, three formulations were suggested by Design Expert 8.0.7.1(Trial Version), among that Formulation B gave better correlation between predicted value and observed value. Thus Formulation B was chosen as global best formulation.