Nucleocytoplasmic Shuttling of the Adapter Protein SH2B1β (SH2-Bβ) Is Required for Nerve Growth Factor (NGF)-Dependent Neurite Outgrowth and Enhancement of Expression of a Subset of NGF-Responsive Genes (original) (raw)

2009, Molecular Endocrinology

AI-generated Abstract

The adapter protein SH2B1 (SH2-B, PSM) is recruited to multiple ligand-activated receptor tyrosine kinases, including receptors for nerve growth factor (NGF). This study investigates SH2B1's role in NGF signaling, demonstrating that depletion of SH2B1 impairs NGF-dependent neurite outgrowth but not AKT or ERK phosphorylation. A critical nuclear localization signal within SH2B1 is identified, necessary for its nuclear translocation, which is essential for enhancing NGF-induced neurite outgrowth and transcription of neurogenic genes. The findings indicate SH2B1's dual function in signaling and transcriptional regulation in the context of NGF.

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