Correlation of Vitamin D Levels with Polycystic Ovary Syndrome: A Cross-sectional Study (original) (raw)
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Vitamin D Levels in Women with Polycystic Ovary Syndrome
KnE Medicine, 2016
Introduction. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is some evidence suggested that vitamin D played a role in the incidence of PCOS. Previous research has found vitamin D deficiency in the pathogenesis of PCOS and cohort studies showing the relationship of obesity with decreased levels of 25-hydroxy vitamin D. Therefore, we aim to conduct a study on vitamin D levels in women with polycystic ovary syndrome. Objective. To determine the difference of the levels of vitamin D in women with and without polycystic ovary syndrome. Methods. This study is a comparative analytical study on two unpaired population by using cross-sectional study design. The study was conducted in Halim Fertility Clinic Medan starting in November 2014 through April 2015. Blood samples were taken from 23 women PCOS and 23 non-PCOS women. Further data were tabulated and analyzed. Results. Vitamin D levels are lower in women with PCOS compared to controls. In the PCOS group, the levels of vitamin D were lower in obese women. Vitamin D levels were also lower in PCOS women with WHR > 0.85. Conclusion. This study showed a significant lower level of vitamin D in PCOS patient.
Indian Journal of Obstetrics and Gynecology Research, 2022
Polycystic ovary syndrome (PCOS) a heterogeneous disorder, characterized by hyperandrogenism, chronic anovulation, obesity, and insulin resistance (IR). Studies have demonstrated the beneficial effect of vitamin D supplementation on insulin resistance in PCOS. Aim: To find the difference of vitamin D level between the PCOS and control groups. And to correlate serum 25(OH)D concentration and metabolic risk factors in PCOS women. Materials and Methods: 49 women, diagnosed with PCOS were recruited as cases and another 49 women without PCOS served as controls. Demographic data like age, BMI, menstrual pattern, clinical features like hirsuitism, acne were recorded for both cases and control. The serum 25(OH)D and metabolic markers were measured. The primary outcome was the difference in vitamin D status between the cases and controls, the secondary outcomes were correlations between serum 25(OH)D concentration and metabolic risk factors in women with PCOS. Results: Vitamin D level was significantly lower in cases than in controls (P < 0.05). The prevalence of IR was significantly greater in the Vitamin D deficiency group among cases (P < 0.05), but not so for BMI and fasting insulin. Also, prevalence of obesity and deranged lipid profile was not significantly increased in the vitamin D deficiency group of PCOS patients. Conclusions: Vitamin D deficiency is prevalent in PCOS women in Eastern India, especially in those with IR and with metabolic risk factors like HDL-C. Larger sample sizes are needed to probe correlation with other metabolic risk factors in PCOS women. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder in women of reproductive age group. It is the leading cause of infertility in females presenting a wide range of clinical manifestations. Aim: To investigate the glycaemic status, calcium, phosphorus, insulin and 25- OH vitamin D levels in women with polycystic ovary syndrome and to compare these parameters with age and BMI matched healthy control women. To find out the correlation between insulin resistance and vitamin D among PCOS women. Materials and Methods: The study comprised of 80 newly diagnosed polycystic ovary syndrome women in the age range of 23 to 33 years. The biochemical parameters measured in the study includes fasting blood sugar, fasting insulin, calcium, phosphorus and vitamin D. The values obtained were compared with equal number of age and body mass indexed (BMI) matched healthy controls. Results and Discussion: In the present study the levels of fasting glucose, fasting insulin were increased, whereas serum calcium and 25 – OH vitamin D levels were decreased in PCOS women when compared with healthy controls. Though serum phosphorous levels appear to be decreased in PCOS women, it is not statistically significant when compared to controls. Conclusion: A high prevalence of vitamin D deficiency and low calcium levels were observed in PCOS women from our population when compared to controls. Insulin resistance was predominantly seen in PCOS subjects when compared with controls, indicating the association of vitamin D levels with insulin resistance.
International Journal of Life Science and Pharma Research
Polycystic ovarian syndrome (PCOS) is the most common heterogeneous multisystem endocrinopathy in women of reproductive age, with an ovarian manifestation of various metabolic disturbances. Based on Rotterdam criteria, PCOS is further classified into four phenotypes. Vitamin D deficiency affects 65- 75% of PCOS patients. There is very little research on the relationship between vitamin D deficiency and PCOS phenotypes. As a result, we intended to investigate the relationship between vitamin D, PCOS, and various PCOS phenotypes. This is a case-control study where we had been 100 people in the study. A total of 50 PCOS participants were classified into phenotype A, phenotype B, phenotype C, and phenotype D using Rotterdam criteria. There were 50 participants who did not have PCOS. Serum vitamin D levels were measured in the study population. The CIDRF (Central Inter-Disciplinary Research Facility) used an ELISA kit and reader to quantify vitamins. The results obtained were further cla...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2013
Polycystic ovary syndrome (PCOS) is the most common metabolic abnormality occurring in young women of reproductive age. Low vitamin D levels were found to be associated with the development of obesity and insulin resistance in young women with PCOS. The study was conducted as a prospective observational study involving 121 women with PCOS. The diagnosis of PCOS cases were based on the revised Rotterdam consensus criteria. Vitamin D levels were compared in the obese and non obese PCOS groups and also with the controls. In the PCOS group, sixty subjects were obese with BMI of ≥25 kg/m 2 and forty seven subjects were found to be non obese. In the control group, sixteen subjects were obese and sixty five subjects were non obese. The mean vitamin D level in the PCOS group was 15.45±7.88 ng/ml and in the control group was 12.83±5.76ng/ml. The mean vitamin D levels in the obese and non obese group with PCOS were 16.11±8.9ng/ml and 14.61±6.1ng/ml respectively. Majority of the patients and controls had vitamin D deficiency and there was no difference in the vitamin D levels in PCOS group and controls as well as obese and non obese groups.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Polycystic ovarian syndrome is the most common hormonal disturbance in the reproductive age women, with prevalence of 5-10%. Vitamin D deficiency is common in women with or without PCOS. The aim of this study was to assess association of serum vitamin D level with metabolic and endocrine dysregulation in women with PCOS.Methods: This cross-sectional study was done over a period of one year. 100 women of age group 20-40 years were divided in group A 30 (BMI >30 mg/m2) with PCOS, group B 20 (BMI <25 mg/m2) with PCOS, group C 50 controls and were investigated for serum FSH, LH, LH/FSH ratio, S. total testosterone, S. postprandial insulin level, glucose insulin ratio, 25 hydroxy vitamin D level.Results: LH/FSH ratio >2 (33.33% in obese and 50% in non-obese), serum total testosterone level >0.8ng/ml (80% in obese and 75% in non-obese) (p value was significant between study group as well as between study and control group). Serum fasting, postprandial blood glucose...
The Professional Medical Journal, 2018
BackgroundPolycystic ovary syndrome (PCOS) is mainstream gynaecological problems in adult women. Vitamin D has been linked to propensity of developing PCO. As this hormones has certain effects on insulin sensitivity and restoration of reproductive capacity in women with PCOs. So, a study was planned to establish correlation of deficiency of vitamin D and PCOs.ObjectiveTo determine the correlation of deficiency of vitamin D with PCOs in patients reporting to a teaching hospital.Material & MethodsCase control study carried out at institute of Shaikh Zayed Hospital, Lahore, Gynae-Obst Department for six months. If serum level of vitamin D is < 25nmol/L then deficiency was labeled. Odds ratio was calculated between PCOs and vitamin D deficiency, ResultsThe mean age of the patients was 26.91±6.09 years. In this study, 70% females were married. The mean BMI of patients was 22.59±2.48kg/m2, and 76(76%) patients had normal BMI and 24(24%) patients were overweight. Vitamin D deficiency wa...
Assessment of Vitamin D Levels in Women with Polycystic Ovarian Syndrome
The Egyptian Journal of Hospital Medicine, 2018
Background: polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with a prevalence of 6-10% in the general population. PCOS is characterized by the following: ovulatory dysfunction resulting in oligo-amenorrhea and/or anovulation, hyperandrogenism and/or hirsutism and the presence of polycystic ovarian morphology by ultrasound. Vitamin D also plays a physiologic role in reproduction including ovarian follicular development and luteinization via altering anti-Müllerian hormone (AMH), signaling, follicle-stimulating hormone sensitivity and progesterone production in human granulosa cells. Aim of the Work: this study aimed to compare levels of vitamin D in women with PCOS and healthy fertile women. Patient and Methods: this case control study was conducted in Ain Shams Maternity hospital in outpatient infertility clinics and family planning clinic during the period from March 2017 to October 2017. It was included 40 women diagnosed with PCOS based on Rotterdam criteria and 40 fertile women without PCOS who were recruited from family planning clinic. Results: 25(OH) vitamin-D level was significantly lower in PCOS group than in the control group. Conclusion: 25(OH) vitamin-D was significantly lower in PCOS group than in the control group, but not sufficient to be a diagnostic tool for PCOS. Recommendation: larger studies are still needed to clarify the rule of vitamin D in infertility.
Vitamin D Level in Unmarried Females with Polycystic Ovarian Syndrome
2016
Objective: To assess and compare the levels of vitamin D in the young unmarried patients of PCOS and healthy females of same age group in population of Rawalpindi. Study Design: A descriptive cross sectional study. Place and Duration of Study: The study was conducted in Gynecology and Obstetrics department of Railway Hospital, Rawalpindi in collaboration with Department of Biochemistry IIMC, Rawalpindi from October, 2014 to April, 2015. Materials and Methods: A sample of 150 young, unmarried females of 16-25 years was enrolled with their written consent in this study. These females were divided into two groups, 50 apparently healthy females and 100 diagnosed patients of polycystic ovarian syndrome selected according to Rotterdam criteria. Vitamin D assay was measured by using 25OH Vitamin D Total Elisa Kit. Data was collected on pre-designed questionnaire. The Data was subjected to SPSS version 21 and analyzed using independent T-test. Results: We had 56% controls and 56% PCOS patie...
Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study
Nutrients
Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking. Methods: We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS (n = 280) versus non-symptomatic controls (n = 1573) at the age of 31 with wide range of endocrine and metabolic confounders. Results: The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, p = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidenc...