Assessment of Health Related Quality of Life in Patients with Epilepsy (original) (raw)
Related papers
QUALITY OF LIFE OF ADULTS WITH EPILEPSY: A DESCRIPTIVE ANALYSIS (Atena Editora)
QUALITY OF LIFE OF ADULTS WITH EPILEPSY: A DESCRIPTIVE ANALYSIS (Atena Editora), 2024
INTRODUCTION: Epilepsy is the most prevalent chronic neurological disease in the world. Treatment is initially pharmacological through anti-epileptic drugs, which include anticonvulsants. The disease negatively impacts quality of life (QoL), and there are standardized scales to measure QoL in Epilepsy, such as QOLIE-31. However, the concept of quality of life is broad and it is necessary to objectively assess which areas of well-being are most impacted by the disease. OBJECTIVES: to describe the quality of life of patients with epilepsy under clinical treatment. METHOD: descriptive study, carried out through review of medical records and application of the internationally validated QOLIE-31 questionnaire. It took place from June 2021 to June 2022 in patients over 18 years of age diagnosed with epilepsy. RESULTS: Seventeen patients participated in the study, 10 men (58.8%) and 7 women, of different ages (the youngest in the 18-29 age group, and the oldest over 70 years old). The responses to the questionnaire were interpreted using the QOLIE-31 formula, which transformed the subjective responses into scores from 0 (worst QLV) to 100 (best possible QLV), divided into 7 parameters - sociability, calmness during seizures, energy, general quality of life, cognitive function, emotional well-being and adaptation to medication. Each parameter evaluated in the questionnaire had its mean, standard deviation, minimum, maximum and median calculated. DISCUSSION: the means of the 7 QOLIE-31 scores demonstrate that the factor with the worst influence on the quality of life of patients with epilepsy is the lack of calmness in having seizures - which is the result of social stigma, insecurity about getting hurt and constant fear of having seizures. The best factor evaluated was the general quality of life, which covered responses that did not depend exclusively on epilepsy. Thus, it can be seen that despite the disease, the patient can present well-being in other areas of life. The other areas evaluated obtained intermediate scores, with averages ranging from 59.5 to 65.4 out of 100 possible points. CONCLUSION: the lack of tranquility in having seizures is the worst factor in the QoL of the patient with epilepsy. The care team must address this fear during consultations, in order to train the patient on how to act in the event of a seizure and thus reduce the negative impact of seizures on their QoL.
Epilepsy & Behavior, 2010
The aim of epilepsy treatment is not only to eliminate seizures, but also to improve health-related quality of life (HRQOL). We conducted a postal self-administered survey of HRQOL for Japanese patients using the Quality of Life in Epilepsy inventory (QOLIE-31), Version 1.0, and analyzed factors influencing their quality of life (QOL). Data from 599 analyzable patients were evaluated and a number of factors influencing QOL were identified, including severity and frequency of seizures, seizure control, type of epilepsy, contributing events such as injuries and falls during seizures, number of antiepileptic drugs, employment status, and surgical outcome. These findings suggest that comprehensive management of the patient should be emphasized. Consideration of all the results led to classification of these factors as one of two types: "all or nothing" and "linear." With respect to "all or nothing" factors (e.g. "daytime remarkable seizures"), patients may not be able to improve their QOL unless these factors can be completely controlled. Comparison of each score on the QOLIE-31 subscales with published data revealed that the scores for the subscale Medication Effects were markedly low.
Research in Neurology: An International Journal, 2015
Background: Epilepsy is a chronic condition which affects quality of life (QOL). QOL is considered as an important outcome measure and component of management in studies of adult epilepsy. Objective: To evaluate factors associated with quality of life in adult epilepsy patients. Materials and Methods: A cross-sectional study was performed to examine the quality of life in 560 adult patients with epilepsy. The data collected included detailed clinical and socio-demographic data, epilepsy details, psychiatric diagnosis (ICD-10 for Mental and behavioral disorders), Liverpool seizure severity scale (LSSS) and Quality of life in epilepsy (QOLIE-31) are assessed. Descriptive statistics-Percentages, ANOVA, Univariate odds and Multiple Logistic Regression analysis with step-down procedure were done. Results: Study population comprised 337 males and 223 females with mean age of 29.26 + 10.83 (range 18-50) years. On Univariate Odds ratio (OR) (95% CI) for single anti-epileptic drug (AED) 2.75(1.85 to 4.09) and absence of psychiatric diagnosis 1.60(1.02 to 2.53) are predictors for good QOL. On one-way ANOVA with QOLIE subscales, seizure frequency and psychiatric diagnosis were found to be statistically significant (p<0.01) but no significant interaction between them. On Logistic Regression step down procedure, psychiatric diagnosis (OR 95% C.I) 7.29(1.65 to 32.10) and multiple AED 1.86(1.24 to 3.51) was found to be predicting factors for poor QOLIE. Conclusion: The presence of psychiatric diagnosis (Depression and Anxiety) was the strongest predictor of poor QOLIE patients. Early psychiatric evaluation and intervention would improve quality of life in epilepsy patients.
Quality of life of Epileptic Patients Compared to General
Epilepsy is a chronic disease that affects different aspects of life; so we studied the quality of life of epileptic patients and compared it with general population of Tehran. We collected clinical and demographic data and studied quality of life by using the Iranian translation of Short Form 36 questionnaire version 2 (SF-36). The questionnaires were filled out by 200 patients with epilepsy referred to the Epilepsy Institute as outpatients. The mean age of our patients was 32.6 years. 54.5% were male. More than 60% of our patients had generalized tonic colonic seizures and seizure frequency was more than once a month in about 40% of them. Patients had lower scores in all subscales of SF-36, which were significantly lower than the general population. Mental health and vitality were the most affected by the disease and physical functioning was the least. Age, marital status, number of children, type of seizure and duration of disease had no effect on quality of life, but gender, educational level, occupation and income did influence quality of life. Clinical factors with significant effects on quality of life were as follows: number of taken drugs, number of adverse effects of drugs, frequency of seizures, and the time passed from last seizure. So we recommend treating patients using least number of drugs with minimum side effects. Striving for seizure free patients is very important and it is vital that we regard quality of life as an important factor in selecting appropriate treatment for patients.
Quality of life in epileptic patients compared with healthy people
Medical journal of the Islamic Republic of Iran, 2016
Epilepsy is a common chronic neurological disorder that has a great impact on people's lives. Patients with epilepsy are at increased risk for poor Quality of Life (QoL). The objective of this study was to evaluate the QoL of epileptic patients in comparison to healthy persons. This cross-sectional study was conducted on 52 epileptic patients from Golbu region in Neyshabur (a city in northeast of Iran). Using Short Form Health Survey (SF-36) scale, the data were collected between April and Jun 2012. Every patient were compared with two healthy persons. Epileptic and healthy persons were similar for age, sex and local residence. Pearson's correlation coefficient and t-independent test applied for data analysis through SPSS v. 16 software. Of 52 epileptic patients, 24 were female (46.2%) and 28 were male (53.8%). The mean±SD age of epileptic patients was 40.92±20.33yr (Rang: 15-86yr). The total mean score of SF- 36 in patient group was 55.88 and in healthy group 68.52and this ...
Quality of Life in Patients with Epilepsy: Study from a Northern Indian Teaching Hospital
Journal of Mahatma Gandhi University of Medical Sciences and Technology
Objectives Epilepsy is a significant public health problem in the world today. The social stigma and impact on quality of life (QOL) may pose a bigger challenge than the clinical severity. In India, there are not many studies using quality of life in epilepsy (QOLIE-31) questionnaire to study the QOL in epileptic patients. This study may be useful in planning the management of patients with epilepsy. So, our study was conducted to determine the level of health-related QOL (HRQOL) of patients with epilepsy in a teaching hospital. Materials and methods This was a cross-sectional, questionnaire-based study conducted in a teaching hospital from March to October 2015. The subjects included both male and female adults of at least 18 years of age with a diagnosis of epilepsy, which was present for minimum 1 year. The QOLIE-31 was used for collecting data on HRQOL. Results Totally, 70 patients with epilepsy were included in the study. The standard deviation (mean) total score of QOLIE-31 in...
Study of quality of life in epilepsy patients with psychiatric co-morbidities using QOLIE-31
2014
Background: Epilepsy is a neurological condition affecting both the sexes in all age groups and is associated with psychiatric co-morbid conditions. There is a paucity of available published data regarding psychiatric co-morbid conditions and quality of life in patients with Epilepsy (PWE) from developing countries. Methods: We evaluated the quality of life in 80 PWE, 80 with asthma (asthma control subjects: AC) and 80 normal healthy patients (normal control subjects: NC) using the QOLIE-31 item inventory. Results: Psychiatric co-morbid conditions are more common in PWE (32.50%) as compared to the AC (17.5%) and NC (7.5%). The quality of life in PWE was significantly lower when compared to control subjects and it was further low in the presence of co-morbid psychiatric disorders. Conclusion: Co-morbid psychiatric disorders should be identified and documented in PWE and treating these disorders apart from the control of seizures may significantly improve their quality of life.
Psychometric evaluation of the Persian version of the quality of life in epilepsy inventory-31
Background: Health assessment in patients with epilepsy (PWE) should include both clinical outcomes and health related quality of life (HRQOL) measures. The quality of life (QoL) in epilepsy-31 inventory (QOLIE-31) is widely used for QOL studies in epilepsy. This study aims to evaluate psychometrics of the Persian version of the inventory (QOLIE-31-P). Methods: Following a standard forward-backward translation and cultural adaptation, the construct validity of the QOLIE-31-P was assessed by explanatory factor analysis, multi-trait scaling analysis, and known group comparison. The criterion validity was assessed by calculating the Pearson correlation to SF-36 (36-item short-form health survey). The reliability was assessed by calculating Cronbach's alpha and test-retest study. Results: The factor analysis extracted from 8 factors explaining 70.35% of the variations. Item-scale correlations revealed that individual items significantly had the strongest association with the domain they were loaded on. The Pearson coefficient of correlation between QOLIE-31-P and the overall scores of SF-36 was 0.876 (P < 0.0001). Patient with medically controlled seizures scored higher than those who experienced seizures during the previous year to study date (P < 0.0001). The Cronbach's α of overall QOLIE-31-P inventory was 0.9. The overall test-retest coefficient of correlation was 0.68 (P = 0.003). Conclusion: QOLIE-31-P is a valid and reliable tool to be applied in health assessment of patients with epilepsy.
Impact of epilepsy on QOL in a Portuguese population: exploratory study
Acta Neurologica Scandinavica, 1998
Objectives-To develop an outcome measure of QOL (quality of life) for the Portuguese population; describe QOL in epileptics; analyse how Q O L is affected by epilepsy and analyse how QOL is affected by patients' characteristics. Patients and methods-Study of a consecutive sample of 92 epileptics from an outpatient clinic, men and women, aged 15-65, having the basic education level. Firm diagnosis of epilepsy (with or without seizures) without other illness. A questionnaire based on ESI-55 and Health Insurance Experiment Short-Forms was used. Principal component analysis (orthogonal varimax) showed a solution explaining 55.6 of total variance. After the inspection, the 33 items were grouped into 5 sub-scales (dimensions). Results-Results showed that Q O L was poor for people with partial seizures. The best scores were found on patients now free from seizures. Conclusion-The QOL measure is sensitive to cultural differences, demographic and disease variables which could explain the results found.