Can intensity of long-term follow-up for survivors of childhood and teenage cancer be determined by therapy-based risk stratification? (original) (raw)

BMJ open, 2013

Abstract

To determine the feasibility of therapy-based, risk-stratified follow-up guidelines for childhood and teenage cancer survivors by evaluating adverse health outcomes in a survivor cohort retrospectively assigned a risk category. Retrospective cohort study. Tertiary level, single centre, paediatric cancer unit in South East Scotland. All children and teenagers diagnosed with cancer (<19 years) between 1 January 1971 and 31 July 2004, who were alive more than 5 years from diagnosis formed the study cohort. Each survivor was retrospectively assigned a level of follow-up, based on their predicted risk of developing treatment-related late effects (LEs; levels 1, 2 and 3 for low, medium and high risk, respectively). Adverse health outcomes were determined from review of medical records and postal questionnaires. LEs were graded using the Common Terminology Criteria for Adverse Event, V.3. 607 5-year survivors were identified. Risk stratification identified 86 (14.2%), 271 (44.6%) and 25...

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