The identification of biophysical parameters which reflect skin status following mechanical and chemical insults (original) (raw)
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Skin Research and Technology, 2013
Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, representing a non-clinical environment, can be highly variable and difficult to control, thereby presenting unique measurement challenges not typically encountered in clinical settings. Methods: An expert working group convened a workshop as part of the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals (OEESC) to develop basic guidelines and best practices (based on existing clinical guidelines, published data, and own experiences) for the in vivo measurement of transepidermal water loss (TEWL) and skin hydration in non-clinical settings with specific reference to the workplace as a worst-case scenario.
A new approach to describe the skin surface physical properties in vivo
Colloids and Surfaces B: Biointerfaces, 2009
In the present paper, we describe a new mechanical method characterising the physico-chemical properties of human skin and their variations along with liquid exposure scenario to the skin surface. A specific bio-tribometer has been developed to study the physical properties of the skin in vivo by measuring the maximum adhesion force between the skin and the bio-tribometer. We showed that the lipidic film present on skin surface was responsible for skin adhesion due to capillary phenomena. The measure of pull-off force between skin and bio-tribometer has permitted to estimate the liquid/vapour surface tension of the lipidic film ( LV ≈ 6.3 mJ/m 2 in 30-year-old volunteer). The kinetic of sorption/desorption (sorption means indifferently adsorption and absorption process) of distilled water from the skin has been observed through the variation of the indenter/skin pull-off force versus time after distilled water application to the skin surface. This permits to follow in real time the variation of the skin physico-chemical properties after liquid application onto the skin surface. Finally, the increasing of skin friction coefficient after distilled water application onto skin surface was explained by the capillary adhesion force between the probe and the skin.
Skin Research and Technology, 2020
Human in vivo skin damage models simulate different cutaneous conditions, and for this reason, they have been used as a substitute for the patients in the clinical trials. 1,2 Models have multiple uses, from the investigation of the changes in the damaged skin, mechanism of the skin damage and healing, kinetics of the skin recovery to effectiveness of different therapeutic agents. 2,3 Protocols for implementation of some models have been standardized and reported in their specific guidelines, 2 but for the
Skin response to mechanical stress: adaptation rather than breakdown--a review of the literature
Journal of rehabilitation research and development, 1995
The abnormal loading of skin and other surface tissues unaccustomed to bearing large mechanical forces occurs under many circumstances of chronic disease or disability. A result of abnormal loading is breakdown of the body wall tissues. An effective rehabilitation program avoids the pathological processes that result in skin trauma and breakdown and encourages load-tolerance and adaptation, changes in the body wall so that the tissues do not enter an irreversible degenerative pathological process. In the past, prevention has been the principal approach to the challenge of maintaining healthy skin and avoiding breakdown; therefore, relatively little is described in the rehabilitation literature about skin adaptation. However, adaptation has been investigated in other fields, particularly biomechanics and comparative anatomy. The purpose of this paper is to assemble the research to date to present the current understanding of skin response to mechanical stress, specifically addressing...
Skin Research and Technology, 2013
Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, representing a non-clinical environment, can be highly variable and difficult to control, thereby presenting unique measurement challenges not typically encountered in clinical settings. Methods: An expert working group convened a workshop as part of the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals (OEESC) to develop basic guidelines and best practices (based on existing clinical guidelines, published data, and own experiences) for the in vivo measurement of transepidermal water loss (TEWL) and skin hydration in non-clinical settings with specific reference to the workplace as a worst-case scenario.
Instrumental possibilities of skin parameters assessment — literature review
Journal of Face Aesthetics
The authors reviewed the literature on the most commonly used devices for measuring skin parameters. The instruments were selected to measure: skin elasticity Cutometer® (Courage-Khazaka, Koln, Germany), Reviscometer® RVM600; hydration while using skin properties such as resistance, capacity, conductivity and impedance, the Corneometer CM 820 and CM 825 (Courage & Khazaka, Koln, Germany), Nova DPM 9003 (Nova Technology Corporation, Gloucester, MA, USA), DermaLab® USB Moisture Module (Cortex Technology, Hadsund, Denmark) and Scalar Moisture Checker MY-808S (Scalar Corporation, Japan), to test percutaneous water loss (TEWL) with Tewameter® TM 300 (Courage-Khazaka, Koln, Germany); high-frequency ultrasound scanners Dub®SkinScanner 75 (TPM Company, Lueneburg, Germany), DermaScan® C USB (Cortex Technology, Hadsund, Denmark); for pH measurement Skin-pH-Meter PH 905 (Courage-Khazaka, Koln, Germany), Skin-pH-Meter PH 900 (Courage-Khazaka, Koln, Germany, pH-Meter 1140 (Mettler Toledo, Urdorf...
1985
The viscoelastic properties of dry, normal, and glycerol-treated skin of the lower leg have been measured with a gas-bearing electrodynamometer (GBE). Elastic modulus measurements are shown to correlate well with visual assessment of the skin condition by a trained dermatological grader. Dry skin is generally stiffer than normal skin and glycerol treatment can indeed soften the skin. Removal of the outer layers of the stratum corneum by tape stripping resulted in an almost 50% reduction in the moduli--indicating a significant contribution to the mechanical properties of the skin from these layers as measured by the GBE.
Characterising the Anisotropic Mechanical Properties of Excised Human Skin
2013
The mechanical properties of skin are important for a number of applications including surgery, dermatology, impact biomechanics and forensic science. In this study we have investigated the influence of location and orientation on the deformation characteristics of 56 samples of excised human skin. Uniaxial tensile tests were carried out at a strain rate of 0.012s$^{-1}$ on skin from the back. Digital Image Correlation was used for 2D strain measurement and a histological examination of the dermis was also performed. The mean ultimate tensile strength (UTS) was 21.6$\pm$8.4MPa, the mean failure strain 54$\pm$17%, the mean initial slope 1.18$\pm$0.88MPa, the mean elastic modulus 83.3$\pm$34.9MPa and the mean strain energy was 3.6$\pm$1.6MJ/m$^3$. A multivariate analysis of variance has shown that these mechanical properties of skin are dependent upon the orientation of Langer lines (P$<$0.0001-P=0.046). The location of specimens on the back was also found to have a significant effect on the UTS (P =0.0002), the elastic modulus (P=0.001) and the strain energy (P=0.0052). The histological investigation concluded that there is a definite correlation between the orientation of Langer Lines and the preferred orientation of collagen fibres in the dermis (P$<$0.001). The data obtained in this study will provide essential information for those wishing to model the skin using a structural constitutive model.