Insights into Global Mechanisms and Disease by Gene Expression Profiling (original) (raw)

Methods in Molecular Biology, 2011

Abstract

Transcriptomics has played an essential role as proof of concept in the development of experimental and bioinformatics approaches for the generation and analysis of Omics data. We are giving an introduction on how large-scale technologies for gene expression profiling, especially microarrays, have changed the view from studying single molecular events to a systems level view of global mechanisms in a cell, the biological processes, and their pathological mutations. The main platforms available for gene expression profiling (from microarrays to RNA-seq) are presented and the general concepts that need to be taken into account for proper data analysis in order to extract objective and general conclusions from transcriptomics experiments are introduced. We also describe the available main bioinformatics resources used for this purpose.

Fatima Sanchez-Cabo hasn't uploaded this paper.

Let Fatima know you want this paper to be uploaded.

Ask for this paper to be uploaded.