MFMET project - Establishing metrology standards in microfluidic devices (original) (raw)
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Zenodo (CERN European Organization for Nuclear Research), 2022
A2.3.1: Literature review of existing metrology and normative standards related to the liquid properties and microfluidic devices Work package 2 https://mfmet.eu Establishing Metrology Standards in Microfluidic Devices This report was written as part of activity 2.3.1 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1 st June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g.
MFMET A3.1.4 White paper on common microfluidic component materials
Zenodo (CERN European Organization for Nuclear Research), 2023
This White Paper was written as part of activity A3.1.4 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1 st June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g. VIM & GUM. For more details about this project, please visit www.mfmet.eu
MFMET A2.3.2: Test protocols for liquid properties related to microfluidic devices
Zenodo (CERN European Organization for Nuclear Research), 2023
Test protocols for at least three liquid properties (such as density, viscosity and refractive index) related to microfluidic devices, and ensuring traceability to national standards and conformity to existing normative standards. www.mfmet.eu Establishing Metrology Standards in Microfluidic Devices This report was written as part of activity A2.3.2 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1 st June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g.
Characterisation of microfluidic devices
2002
Silicon micromachining techniques have enabled the fabrication of a wide range of microfluidic components and systems. Given the small volumes of liquid and low flow rates involved, the accurate characterisation of such systems presents a challenge. To date many of the measurements have been performed manually; this is both time consuming and prone to inaccuracies. This paper describes an automated measurement technique and presents results for a surface micromachined valve.
Review of production of microfluidic devices: material, manufacturing and metrology
MEMS, MOEMS, and Micromachining III, 2008
Microfluidic devices play a crucial role in biology, life sciences and many other fields. Three aspects have to be considered in production of microfluidic devices: (i) material properties before and after processing, (ii) tooling and processing methodologies, and (iii) measurements for process control. This paper presents a review of these three areas.
MFMET A2.1.1: Metrology Methodology
2021
This report was written as part of activity 2.1.1 from the EMPIR Establishing Metrology Standards in Microfluidic Devices (MFMET) project. The three-year European project commenced on 1<sup>st</sup> June 2021 and focused on providing a generic methodology of accurate measurement of a particular quantity in a microfluidic device by utilising standardised methods and reference documents, e.g. VIM & GUM. For more details about this project, please visit www.mfmet.eu The document provides a description of a generic methodology of accurate measurement of a quantity by utilizing standardized methods and reference documents, e.g. VIM (International Vocabulary of Metrology) & GUM (Evaluation of measurement data – Guide to the expression of uncertainty in measurement).
Analysis system for characterisation of simple, low-cost microfluidic components
Sensors, MEMS and Electro-Optical Systems, 2014
There is an inherent trade-off between cost and operational integrity of microfluidic components, especially when intended for use in point-of-care devices. We present an analysis system developed to characterise microfluidic components for performing blood cell counting, enabling the balance between function and cost to be established quantitatively.
Specification, Integration, and Benchmarking of Continuous Flow Microfluidic Devices: Invited Paper
2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD)
The lack of standardization in the specification and representation of microfluidic designs and their corresponding architectures is one of the largest hurdles faced by the developers of Microfluidic Design Automation (MDA) tools. In this paper, we introduce MINT, a Microfluidic Hardware Description Language (MHDL) for defining components and devices in a human readable manner, and Parch-Mint, an MDA interchange format and associated benchmark suite that can be used to compare the performance of different physical design algorithms. We further demonstrate how the introduction of MINT and ParchMint into the engineering workflow can bridge the gaps from the specification to the fabrication of microfluidic devices. While recent efforts to democratize microfluidics have been recognized by the community, there is an unfortunate lack of open source tools, design languages, and standards. Consequently, microfluidic designs shared on open platforms such as Metafluidics[15] leave conceptual gaps in terms of missing design information that are necessary to realize the "creative process flows" (Reproduce, Remix, and Test multiple systems). MINT and ParchMint are open source projects, which allows the community to contribute and extend their functionality to enable advanced algorithmic methodologies and new commercialization possibilities that differ from the vertically integrated industries we see today.
Microfluidic Apps for off-the-shelf instruments
Lab on a Chip, 2012
Within the last decade a huge increase in research activity in microfluidics could be observed. However, despite several commercial success stories, microfluidic chips are still not sold in high numbers in mass markets so far. Here we promote a new concept that could be an alternative approach to commercialization: designing microfluidic chips for existing off-the-shelf instruments. Such ''Microfluidic Apps'' could significantly lower market entry barriers and provide many advantages: developers of microfluidic chips make use of existing equipment or platforms and do not have to develop instruments from scratch; end-users can profit from microfluidics without the need to invest in new equipment; instrument manufacturers benefit from an expanded customer base due to the new applications that can be implemented in their instruments. Microfluidic Apps could be considered as low-cost disposables which can easily be distributed globally via web-shops. Therefore they could be a door-opener for high-volume mass markets. Microfluidics and mTAS The original concept of miniaturized total analysis systems (mTAS) was introduced by Andreas Manz et al. in 1990. 1 He promoted the integration of processing steps necessary for chemical analysis into a single chip by making use of miniaturization. Nowadays this field of research is also known as microfluidics. In view of currently more than 3000 publications annually, 2 research in the field of mTAS and microfluidics can indeed be regarded as an extraordinary scientific success story. Especially the introduction of poly(dimethylsiloxane) (PDMS) in the late 1990s 3 and the concept of ''microfluidic large scale integration'' can be considered as milestones for the microfluidics community, since they enabled parallel control over thousands of valves and hundreds of chambers on a single chip with an edge length of only a few centimetres. 4,5