Effects of reduced energy availability on bone metabolism in women and men (original) (raw)

The short-term effects of low energy availability (EA) on bone metabolism in physically active women and men are currently unknown. We evaluated the effects of low EA on bone turnover markers (BTMs) in a cohort of women and a cohort of men, and compared effects between sexes. These studies were performed using a randomised, counterbalanced, crossover design. Eleven eumenorrheic women and eleven men completed two 5-day protocols of controlled (CON; 45kcal·kgLBM(-1)·d(-1)) and restricted (RES; 15kcal·kgLBM(-1)·d(-1)) EAs. Participants ran daily on a treadmill at 70% of their peak aerobic capacity (VO2 peak) resulting in an exercise energy expenditure of 15kcal·kgLBM(-1)·d(-1) and consumed diets providing 60 and 30kcal·kgLBM(-1)·d(-1). Blood was analysed for BTMs [β-carboxyl-terminal cross-linked telopeptide of type I collagen (β-CTX) and amino-terminal propeptide of type 1 procollagen (P1NP)], markers of calcium metabolism [parathyroid hormone (PTH), albumin-adjusted calcium (ACa), ma...